Days After
Starting
Chemo
Therapy
ALT
(U/L)
Alk P
(U/L)
Bilirubin
(mg/dL)
Comments
1Started oral prednisone and weekly doses of vincristine and streptonigrin
11V & S91050.8
17V & S10100
24V & S11105
31S1390
38S1190
53Rad15135
88Rad & V25140
111Admission40002555.8Jaundice, ascites, fever
113Day 215502306.0
117Day 618526510.0
122Day 118840520.0
131Day 206234020.5
141Day 30Died of hepatic failure
Normal Values <30 <275 <1.2
*

Abbreviations: Rad=radiation therapy, S=oral streptonigrin, V=vincristine infusion.

From: Vinca Alkaloids

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LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet].

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