GEO DataSets

(Submitter supplied) In this study, we investigated the effect of LY294002 on gene expression in Hodgkin lymphoma cell line KMH2 cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL201

5 Samples

Download data: CEL

(Submitter supplied) The 17beta-hydroxy steroid dehydrogenase family is involved in the fine tuning of conversion of different substances such as steroids, retenoids and fatty acids. The expression of HSD17B14 has been correlated to better prognosis in breast cancer. The function of HSD17B14 is still not known, but it may convert estradiol to estrone. We transfected breast cancer cell lines with a HSD17B14-containing plasmid and compared with mock-transfected samples. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL201

8 Samples

Download data: CEL

(Submitter supplied) MicroRNA (miRNA) deregulation has long been associated with various cancers. Among an expanding list of cancer related miRNAs, deregulation of miR-125b has been well documented in various cancers including breast. Based on current knowledge, miR-125b is considered to be a tumor suppressor in breast cancers. While important mRNA targets have been defined for miR-125b, here, we aimed to further investigate direct/indirect consequences of miR-125b expression in breast cancer cells by using a transcriptome approach. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL201

9 Samples

Download data: CEL

(Submitter supplied) The purpose of this study is to investigate certain genes inuduced/reduced by NK150460, novel compound possessing antitumor activity. To identify genes, time course samples were prepared from NK150460 sensitive and insensitive breast cancer cell lines. By comparing patterns in both sensitive and resistant cell lines, we tried to identify genes specifically modulated by NK150460 treatment.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL201

20 Samples

Download data: CEL, CHP, TXT

(Submitter supplied) Study the effects of 3 weeks training exercise in chronic obstructive pulmonary disease (COPD) patients and healthy individuals. Skeletal muscle biopsies of 5 COPD patients (aged 63±2 year) and 3 age-matched healthy individuals were studied before and after 3 weeks of a supervised endurance training program.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL201

16 Samples

Download data: CEL

(Submitter supplied) Background: Oral squamous cell carcinoma (OSCC) is a major world health problem with over 400,000 new cases diagnosed annually. Despite advances in surgery and chemo-radiotherapy, the 5 year survival has remained roughly constant at approximately 50% for several decades. The disease is characterized by both clinical and genetic heterogeneity, so elucidating the molecular basis of this heterogeneity would have significant clinical implications. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL570 GPL201

56 Samples

Download data: CEL

(Submitter supplied) The current study analyzed a unique, serum-free medium derived tongue squamous cell carcinoma (TSCC) line termed LK0412 relative to the normal state to elucidate biomarkers at the protein and transcript level. A bioinformatics approach using Gene Ontology categories, gene networks and signature evaluation was applied to combine the protein and transcript data for identification of various gene signatures. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL201

5 Samples

Download data: CEL, CHP

(Submitter supplied) Serum-driven responses, many of which are related to wound healing, are potentially deregulated in cancer development and associated genomic alterations might have prognostic value. The current study assessed fetal bovine serum-induced transcriptomic changes for clinical relevance in head and neck squamous cell carcinoma (HNSCC) using oral keratinocyte models otherwise routinely cultured without serum, including normal keratinocytes (NOK) and the transformed keratinocyte lines SVpgC2a, SqCC/Y1 and LK0412. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL201

28 Samples

Download data: CEL, CHP

(Submitter supplied) DNA microarray analysis revealed that the genes related to cell cycle regulation were significantly induced at non- and sub-lethal concentrations (i.e., 0.05-6 µM), while the common feature of heavy metal toxicity such as oxidative damage and following increase in glutathione, heat shock proteins, and metallothionein were confirmed at high concentrations (i.e., 6-40 µM). The concentration dependent modulation of gene expression (induction of cell cycle genes, induction of cell cycle arrest genes and apoptotic genes) following exposure to arsenic was further supported by acceleration of cell proliferation, ROS generation, and cytotoxicity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL201

21 Samples

Download data: CEL, CHP

(Submitter supplied) Effect of chlorination on the toxicity of wastewater effluents treated by activated sludge (AS) and submerged membrane bioreactor (S-MBRB) systems to HepG2 human hepatoblastoma cells was investigated. In addition to cytotoxicity assay, the DNA microarray-based transcriptome analysis was performed to evaluate the change in modes of toxic actions (MOAs) of effluents by chlorination. Effluent organic matters (EfOM) and disinfection by-products (DBPs) were characterized by using Fourier transform mass spectrometry (FT-MS). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL201

16 Samples

Download data: CEL, CHP

(Submitter supplied) The effect of preventive vaccination against Human Papillomavirus (HPV) in reducing the burden of cervical cancer (CC) will not be seen before 30 years. It is still necessary to improve the procedures of screening and treatment against CC. Current methods for screening have low sensitivity (Pap test) or specificity (HPV tests) to detect high-grade cervical intraepithelial neoplasias (CIN) and CC (CIN2+). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL201 GPL6244

79 Samples

Download data: CEL

(Submitter supplied) The transcriptome analysis by the human DNA microarray was applied to evaluate the impacts of whole wastewater effluents from the membrane bioreactors (MBRs) and the activated sludge process (AS), on the biological processes of human hepatoma HepG2 cells. The three conventional bioassays (i.e., cytotoxicity tests and bioluminescence inhibition test) and chemical analysis of the domestic effluent standards were conducted in parallel since they are well-established methods with previous applications to wastewater. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL201

14 Samples

Download data: CEL, CHP

(Submitter supplied) Objective: to focus on the molecular mechanisms involved in the ALS related atrophy process that leads to selective wasting muscles .

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL201

14 Samples

Download data: CEL

(Submitter supplied) Background: Dengue virus (DENV) infection often leads to acute illness lasting 2-7 days with severity ranging from dengue fever (DF) to hemorrhagic fever (DHF) and fatal dengue shock syndrome (DSS). The dynamic changes of host responses on the gene transcription level that accompany DENV infection and differences between DF and DHF cases have been poorly understood, particularly for South American population. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL570 GPL201

269 Samples

Download data: CEL

(Submitter supplied) Objective: Identify genes that are differentially expressed between critically ill trauma patients who go on to develop ventilator-associated pneumonia (VAP) compared to similar patients who do not develop VAP Using gene expression differences, develop a model that predicts which patients are at greater risk of developing VAP.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL201

20 Samples

Download data: CEL

(Submitter supplied) The hypothesis was that 6 months of dietary n-3 FA supplementation to humans affected expression of genes that might be of significance for inflammatory processes and for Alzheimer´s disease.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL201

31 Samples

Download data: CEL

(Submitter supplied) In this report we applied standard and original methods of analysis of gene expression microarray data to delineate differences in the molecular pathways impacted by stimulation of Epstein-Barr virus (EBV) transformed B cells derived from patients with systemic lupus erythematosus (SLE) and normal unrelated controls. In order to understand the dynamics and interconnections the B cell molecular pathways, the system was perturbed with a biologically relevant signal, co-crosslinking of the B cell antigen receptor (BCR) and FcγR2b and global gene expression changes were assessed at various timepoints post-stimulation. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL201

104 Samples

Download data: CEL

(Submitter supplied) 8-oxoguanine is excised from DNA by 8-oxoguanine DNA glycosylase-1 during DNA base excision repair. We used microarrays to gain insight into the potential biological function of the excised, free 8-oxoguanine base.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL571 GPL201

8 Samples

Download data: CEL, CHP

(Submitter supplied) Lim Mineralization Protein, splice variant-3 (LMP3) is known to induce osteoblast differentiation as a result of active modulation of selected molecules involved in the osteogenic cascade. LMP3 seems to act as an upstream modulator of osteogenic differentiation, although the complete network of molecular events involved in this process are still largely unknown. In particular, LMP3 seems to act, at least in part, through the upregulation of bone morphogenetic proteins (BMPs) which are known to exert multiple functions, leading to the regulation of diverse cellular processes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL201

9 Samples

Download data: CEL, CHP

(Submitter supplied) We used microarrays to examine gene expression levels from members of 45 CEPH-Utah pedigrees. Keywords: array-based gene expression

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL201

695 Samples

Download data: CEL