GEO DataSets

Analysis of estrogen receptor (ER)-positive breast cancer cell line MCF-7 depleted for KDM3A (histone lysine demethylase 3A) then treated with estrogen. Histone lysine methylation is an important regulator of transcription. Results provide insight into role of KDM3A in ER signaling in breast cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:

GPL10558

Series:

GSE68918

11 Samples

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Analysis of LNCaP prostate cancer (PCa) cells overexpressing miRNA-135b for up to 36 hours. LNCaP cells express the androgen receptor (AR). MiRNA-135b overexpression in AR+ PCa cells results in slower growth compared to AR knockdown. Results provide insight into the basis of this slower growth.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 protocol, 3 time sets

Platform:

GPL10558

Series:

GSE57820

12 Samples

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Analysis of U937 monocytic cells infected at multiplicities of infection of 0.0002 and 0.02 with the Sendai virus. Results provide insight into the differences between the innate immune response of cells infected with a low and high concentration of virus.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 dose, 2 infection sets

Platform:

GPL10558

Series:

GSE67198

11 Samples

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Analysis of primary plasmacytoid dendritic cells (pDC) exposed to influenza A for 8 hours ex vivo. pDCs are vital to antiviral defense, directing immune responses via secretion of interferon-alpha. Results provide insight into the regulation of the response of pDC to viral pathogens.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 5 individual, 2 infection sets

Platform:

GPL10558

Series:

GSE68849

10 Samples

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Analysis of the total population of monocytes from patients with metastatic breast cancer (MBC), sepsis, or tuberculosis. Results provide insight into molecular similarities between monocytes from MBC patients and reprogrammed immunosuppressive monocytes from sepsis patients.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 4 disease state sets

Platform:

GPL10558

Series:

GSE65517

13 Samples

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Analysis of ARID1A-mutated OVISE ovarian clear cell carcinoma (OCCC) cells restored with wild-type ARID1A or treated with GSK126, an inhibitor of epigenetic regulator EZH2. Epigenetic modifier ARID1A is often mutated in OCCC. Results provide insight into the role of epigenetic mechanisms in OCCC.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 genotype/variation sets

Platform:

GPL10558

Series:

GSE54979

9 Samples

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Analysis of basal-like breast cancer (BC) cell lines MDA-MB-468 and BT-549 treated with protein kinase C δ (PKCδ) siRNA to induce apoptosis. Results provide insight into candidate apoptosis regulators in BC cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 cell line, 2 protocol sets

Platform:

GPL10558

Series:

GSE55503

12 Samples

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Analysis of non-invasive NeuN cells and invasive NeuT cells (i.e., MCF10A cells overexpressing wild-type ERBB2 or a constitutively active mutant of ERBB2, respectively) treated with IFF. Results provide insight into the molecular pathways activated by IFF in ERBB2-positive breast cancer cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 cell line, 2 protocol sets

Platform:

GPL10558

Series:

GSE64670

12 Samples

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Analysis of MCF10A cells expressing ERBB4 intracellular domain (ICD) isoforms, CYT-1 or CYT-2. ERBB4 is a member of the epidermal growth factor receptor family. MCF10A cells lack endogenous ERBB4 expression. Results provide insight into the diverse transcriptional activities of ERBB4 isoforms.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 genotype/variation sets

Platform:

GPL10558

Series:

GSE57339

12 Samples

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Analysis of extracellular vesicles (EVs) from the urine of bladder cancer (BC) patients. Results provide insight into the potential use of mRNAs associated with urinary EVs as non-invasive diagnostic biomarkers of BC.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state sets

Platform:

GPL10558

Series:

GSE51843

11 Samples

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Analysis of peripheral blood of untreated patients with stage 1 Parkinson's disease (PD), according to the Hoehn-Yahr scale, and paired healthy, age- and sex-matched controls. Results provide insight into molecular mechanisms underlying the initiation of the development of PD.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 10 individual sets

Platform:

GPL10558

Series:

GSE54536

10 Samples

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Analysis of induced pluripotent stem cell-derived epithelial stem cells (hiPSC-EpSCs). The hiPSCs, which were derived from adult dermal fibroblasts, and hEpSCs directly isolated from hair follicles also examined. Results provide insight into molecular similarities between hiPSC-EpSCs and hEpSCs.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 cell type, 2 tissue sets

Platform:

GPL10558

Series:

GSE51028

7 Samples

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Analysis of dasatinib-resistant and dasatinib-sensitive PC cell lines. Dasatinib, a small-molecule kinase inhibitor, is FDA-approved for PC, but certain PC cells can have intrinsic or acquired resistance to dasatinib. Results provide insight into molecular basis of dasatinib-resistance in PC cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 6 cell line, 2 cell type sets

Platform:

GPL10558

Series:

GSE59357

18 Samples

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Analysis of PBMCs isolated from an IRF7-deficient patient and infected with influenza A/CA/4/2009 for up to 16 hrs. Transcription factor IRF7 amplifies type I and III interferon response to viruses. Results provide insight into the role of IRF7 in antiviral immunity.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 6 individual, 2 infection, 3 time sets

Platform:

GPL10558

Series:

GSE66486

18 Samples

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Analysis of bone marrow (BM) mesenchymal stromal cells from adult patients representing MDS subtypes RCMD (refractory cytopenia with multilineage dysplasia) and RAEB (refractory anemia with excess blasts). Results provide insight into molecular changes in the BM microenvironment contributing to MDS.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 4 disease state sets

Platform:

GPL10558

Series:

GSE61853

14 Samples

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Analysis of estradiol-treated, progesterone receptor (PR)-low/estrogen receptor (ER)+ MCF7 breast cancer cells stably-expressing PR-B. Progesterone and estrogen are major drivers of breast cancer. Results provide insight into the molecular cross-talk between ER and PR-B in breast cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:

GPL10558

Series:

GSE45643

12 Samples

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Analysis of MDA-MB-231 breast cancer cells treated with DOT1L (disruptor of telomeric silencing 1 like) inhibitor Compound 55 or DOT1L siRNA. DOT1L is a histone H3-lysine79 (H3K79) methyltransferase. Results provide insight into the role of DOT1L/H3K79 methylation in breast cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 agent, 4 dose sets

Platform:

GPL10558

Series:

GSE56630

8 Samples

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Analysis of MDA-MB-231 breast cancer cells treated with DOT1L (disruptor of telomeric silencing 1 like) inhibitor EPZ004777 or DOT1L siRNA. DOT1L is a histone H3-lysine79 (H3K79) methyltransferase. Results provide insight into the role of DOT1L/H3K79 methylation in breast cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 agent, 4 dose sets

Platform:

GPL10558

Series:

GSE56630

8 Samples

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Analysis of lymphoma cell lines DOHH2 (derived from GCB-DLBCL) and TMD8 (derived from ABC-DLBCL) exposed to ST7612AA1 (300nM) for 8 hrs. ST7612AA1 is an oral thiol-based histone deacetylase inhibitor (HDACi). Results provide insight into the molecular mechanisms underlying ST7612AA1 action in DLBCL.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 2 cell line sets

Platform:

GPL10558

Series:

GSE62460

12 Samples

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Analysis of skeletal muscle biopsies collected at 1.5, 4, 10, and 24hr post-meal time from healthy young men subjected to a 24hr fast. Results provide insight into the molecular mechanisms underlying metabolic adaptation to fasting in healthy humans.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 12 individual, 4 time sets

Platform:

GPL10558

Series:

GSE55924

48 Samples

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