Similar studies for GEO DataSets (Select 200044841) - GEO DataSets

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Items: 20

Select item 2000448411.

Microarray analysis of differentiation of human glioblastoma neurospheres

(Submitter supplied) Brain tumor neurospheres (BTCSs) are cancer cells with neural stem cell-like properties found in the fatal brain tumor glioblastoma multiforme (GBM). These cells account for less than 1% of total tumor cells, are poorly differentiated and are believed to be involved in tumor induction, progression, treatment resistance and relapse. Specific miRNAs play important roles in modulating the proliferation and differentiation of neural stem cells, therefore, we aimed to identify miRNAs controlling differentiation in GBM-BTSCs through high throughput screening miRNA array profiling. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
8 Samples

Download data: CEL

Series

Accession:: GSE44841

ID:: 200044841

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000213362.

GBM_SC_retinoic acid_gene_expression

(Submitter supplied) This study compared the gene expression change of glioblastoma stem-like cells before and after retinoic acid treatment

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5175
12 Samples

Download data: CEL, TXT

Series

Accession:: GSE21336

ID:: 200021336

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000655763.

Identification and molecular characterization of distinct glioblastoma cancer stem cell populations

(Submitter supplied) Malignant glioblastoma (GBM) is a highly aggressive brain tumor with a dismal prognosis and limited therapeutic options. Genomic profiling of GBM samples in the TCGA database has identified four molecular subtypes (Proneural, Neural, Classical and Mesenchymal), which may arise from different glioblastoma stem-like cell (GSC) populations. In the present study, we identify two GSC populations that produce GBM tumors by subcutaneous and intracranial injection with identical histological features. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
12 Samples

Download data: IDAT

Series

Accession:: GSE65576

ID:: 200065576

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000207364.

Microarray analysis of differentiation of human glioblastoma stem cells

(Submitter supplied) Glioblastoma multiforme is one of the most devastating cancers and presents unique challenges to therapy due to its aggressive behaviour. Cancer stem cells have been described to be the only cell population with tumorogenic capacity in glioblastoma. Therefore, effective therapeutic strategies targeting these cells may be beneficial. We have established different cultures of glioblastoma stem cells (GSCs) derived from surgical specimens and found that, after induction of differentiation, NFκB was activated, which allows intermediate tumor precursor cells to remain cycling. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4535
Platform:: GPL570
6 Samples

Download data: CEL

Series

Accession:: GSE20736

ID:: 200020736

Select item 45355.

Differentiating glioblastoma-initiating cells

Analysis of cultures of progenitor and 4-day differentiated glioblastoma cells (GICs) derived from surgical specimens. Following induction of differentiation, NFκB is activated in GICs. Results provide insight into molecular mechanisms underlying the control of differentiation of GICs.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 cell type, 3 specimen sets

Platform:: GPL570
Series:: GSE20736
6 Samples

Download data: CEL

DataSet

Accession:: GDS4535

ID:: 4535

Select item 2000594846.

Expression data for miR-33a over-expression in CD133-negative D456MG cells

(Submitter supplied) MiR-33a is involved in the maintenance of Glioma Initiating Cells (GIC) and tumor progression. MicroRNA-33a could promote GIC growth and self-renewal by regulating two pathways including cAMP/PKA pathway and Notch pathway. We used microarrays to identify the direct target genes of miR-33a in a glioblastoma cell line D456MG. We used microarrays to detail the global change of gene expression after miR-33a over-expression and identified target genes during this process.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL571
2 Samples

Download data: CEL

Series

Accession:: GSE59484

ID:: 200059484

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000437627.

Expression profiling of glioma initiating cells (GICs) in the sphere and differentiation conditions

(Submitter supplied) Glioma initiating cells (GICs) are considered responsible for the therapeutic resistance and recurrence of malignant glioma. To clarify the molecular mechanism of GIC maintenance/differentiation, we established GIC clones from GBM patient tumors having the potential to differentiate into malignant gliomas in mouse intracranial xenograft, and established an in vitro glioma induction system by using serum stimulation. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
8 Samples

Download data: CEL

Series

Accession:: GSE43762

ID:: 200043762

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000532208.

Genomic analyses reveal miR-137 broad impact on genes associated with malignant transformation and neuronal differentiation in glioblastoma cells

(Submitter supplied) miR-137 plays critical roles in the nervous system and tumor development. An increase in its expression is required for neuronal differentiation while its reduction is implicated in gliomagenesis. To evaluate the potential of miR-137 in glioblastoma therapy, we conducted genome-wide target mapping in glioblastoma cells by measuring levels of associations between PABP and mRNAs in cells transfected with miR-137 mimics vs. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL10999
16 Samples

Download data: BED

Series

Accession:: GSE53220

ID:: 200053220

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000757899.

GBM miR338-p5

(Submitter supplied) Glioblastoma multiforme (GBM) is the most aggressive form of brain tumors. Despite radical surgery and radiotherapy supported by chemotherapy, the disease still remains incurable with extremely low median survival rate of 12-15 months from the time of initial diagnosis. The main cause of treatment failure is considered to be the presence of cells that are resistant to such treatment. MicroRNAs (miRNAs) as regulators of gene expression are involved in the tumor pathogenesis, including GBM. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
6 Samples

Download data: CEL

Series

Accession:: GSE75789

ID:: 200075789

Select item 20016593710.

MicroRNA-138 Suppresses Glioblastoma Proliferation through Downregulation of CD44 (NanoString)

(Submitter supplied) 100 ng of total RNA was processed with the Human v3 miRNA Expression Assay using NanoString nCounter system (NanoString, USA). Expression of individual miRNA was measured by quantitative real-time PCR with TaqMan miRNA Expression kit (Applied Biosystems, Thermo Fisher Scientific, USA).

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL24781
13 Samples

Download data: RCC

Series

Accession:: GSE165937

ID:: 200165937

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Select item 20016528611.

MicroRNA-138 Suppresses Glioblastoma Proliferation through Downregulation of CD44

(Submitter supplied) MicroRNA-138 Suppresses Glioblastoma Proliferation through Downregulation of CD44

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
13 Samples

Download data: TXT

Series

Accession:: GSE165286

ID:: 200165286

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20005144112.

Sox2 promotes malignancy in glioblastoma by regulating plasticity and astrocytic differentiation

(Submitter supplied) Making use of a previously described isogenic cancer stem cells and serum differentiated cultures we show that Sox2 controls developmental stated specific programs in glioblastoma. Glioblastoma cells were cultured as control and with SOX2 knockdown to identify the scope of SOX2 interactions. The SOX2 knockdown were accomplished using two knockdown technologies. The knockdown cells were compared to controls, early passage, and scrambled controls. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
8 Samples

Download data: TXT

Series

Accession:: GSE51441

ID:: 200051441

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20011898313.

Gene expression data in U87MG cell line transfected with miR-490 overexpression vector PC-490 or its control PCDNA3.1 (+).

(Submitter supplied) miR-490 is robustly downregulated in GBM tumour samples. This study identifies the genes differentially expressed upon miR-490 overexpression in U87MG glioblastoma cell line. GeneChip PrimeView Human Gene Expression Array was used to assess mRNA expression profile in response to miR-490 overexpression in U87MG cell line.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL15207
4 Samples

Download data: CEL

Series

Accession:: GSE118983

ID:: 200118983

Full text in PMC Similar studies Analyze with GEO2R

Select item 20005479214.

Epigenomic profiling of stemness, differentiation and primary tissues in human glioblastoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL16791 GPL11154
49 Samples

Download data: BED, BIGWIG, BW

Series

Accession:: GSE54792

ID:: 200054792

PubMed Full text in PMC Similar studies

Select item 20005479115.

Reconstructing and reprogramming the tumor propagating potential of glioblastoma stem-like cells: RNA-seq

(Submitter supplied) Developmental fate decisions are dictated by master transcription factors (TFs) that interact with cis-regulatory elements to direct transcriptional programs. Certain malignant tumors may also depend on a cellular hierarchy reminiscent of normal development but superimposed on underlying genetic aberrations. In glioblastoma (GBM), a subset of stem-like tumor- propagating cells (TPCs) appears to drive tumor progression and underlie therapeutic resistance, yet remain poorly understood. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL16791 GPL11154
23 Samples

Download data: BW, TXT

Series

Accession:: GSE54791

ID:: 200054791

PubMed Full text in PMC Similar studies

Select item 20005404716.

Reconstructing and reprogramming the tumor propagating potential of glioblastoma stem-like cells: ChIP-seq

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11154 GPL16791
26 Samples

Download data: BED, BIGWIG

Series

Accession:: GSE54047

ID:: 200054047

PubMed Full text in PMC Similar studies

Select item 20015599417.

Comparative analysis of glioblastoma initiating cells and patient-matched EPSC-derived neural stem cells as a discovery tool and drug matching strategy

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Methylation profiling by genome tiling array

4 related Platforms
156 Samples

Download data: COV, IDAT

Series

Accession:: GSE155994

ID:: 200155994

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20015598518.

Comparative analysis of glioblastoma initiating cells and patient-matched EPSC-derived neural stem cells as a discovery tool and drug matching strategy [array]

(Submitter supplied) Malignant gliomas are the most common intrinsic brain tumors in adults and are associated with a very poor prognosis, which has not improved in the last 20 years. We show here that glioblastoma initiating cells (GIC) and syngeneic neural stem cells derived from enhanced pluripotent stem cells (iNSC) are a suitable novel pre-clinical pipeline to discover new patient-specific disease mechanisms and to identify druggable targets for personalized therapy.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL23976
62 Samples

Download data: IDAT

Series

Accession:: GSE155985

ID:: 200155985

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20015495819.

Comparative analysis of glioblastoma initiating cells and patient-matched EPSC-derived neural stem cells as a discovery tool and drug matching strategy [RNA-Seq]

(Submitter supplied) Malignant gliomas are the most common intrinsic brain tumours in adults and are associated with a very poor prognosis, which has not improved in the last 20 years. We show here that glioblastoma initiating cells (GIC) and syngeneic neural stem cells derived from enhanced pluripotent stem cells (iNSC) are a suitable novel pre-clinical pipeline to discover new patient-specific disease mechanisms and to identify druggable targets for personalised therapy.