Similar studies for GEO DataSets (Select 200093057) - GEO DataSets

Links from GEO DataSets

Items: 20

Select item 2000930571.

RNAseq analysis of patient-derived luminal breast cancer xenografts treated with progestins

(Submitter supplied) Primary breast cancer xenografts

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
12 Samples

Download data: FPKM_TRACKING

Series

Accession:: GSE93057

ID:: 200093057

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000939442.

Estrogen and progesterone receptor dynamics in patient-derived luminal breast cancer xenografts

(Submitter supplied) Progesterone receptors (PR) are co-expressed in over half of estrogen receptor (ER) positive breast cancers and predict positive response to endocrine therapy. PR can directly and globally modify ER action to attenuate tumor growth. However, whether this suppression occurs solely through PR-ER interactions remains unknown. We assessed tumor growth in two highly ER and PR positive breast cancer patient-derived xenografts (PDX) and found that natural and synthetic progestins potently antagonize the mitogenic effects of estrogens. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL11532
12 Samples

Download data: CEL

Series

Accession:: GSE93944

ID:: 200093944

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000931083.

ChIPseq analysis of patient-derived luminal breast cancer xenografts with progestins

(Submitter supplied) Primary breast cancer xenografts

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
24 Samples

Download data: BED

Series

Accession:: GSE93108

ID:: 200093108

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000803674.

Genomic agonism and phenotypic antagonism between estrogen and progesterone receptors in breast cancer. [ChIP-seq]

(Submitter supplied) Transcriptomic changes and estrogen and progesterone receptor binding in multiple ER+/PR+ models (eight ER+/PR+ patient tumors, various T47Ds, ZR75) and multiple ER+/PR-negative models (four ER+/PR- patient tuumors, PR-deficient T47D and MCF7 cells) treated with various hormone combinations. Results: In isolation, estrogen and progestin act as genomic agonists by regulating the expression of common target genes in similar directions, but at different levels. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
26 Samples

Download data: BED

Series

Accession:: GSE80367

ID:: 200080367

PubMed Full text in PMC Similar studies

Select item 2000803665.

Genomic agonism and phenotypic antagonism between estrogen and progesterone receptors in breast cancer. [cell models RNA-seq]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
28 Samples

Download data: CSV

Series

Accession:: GSE80366

ID:: 200080366

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000803656.

Genomic agonism and phenotypic antagonism between estrogen and progesterone receptors in breast cancer. [tumor samples RNA-seq]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
48 Samples

Download data: CSV

Series

Accession:: GSE80365

ID:: 200080365

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000800987.

Genomic agonism and phenotypic antagonism between estrogen and progesterone receptors in breast cancer.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
102 Samples

Download data

Series

Accession:: GSE80098

ID:: 200080098

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000226008.

Tissue Specific Pathways for Estrogen Regulation of Ovarian Cancer Growth and Metastasis

(Submitter supplied) Menopausal estrogen (E2) replacement therapy increases the risk of estrogen receptor (ER)-positive epithelial ovarian cancers (EOC). Whether E2 is tumorigenic or promotes expansion of undiagnosed pre-existing disease is unknown. To determine E2 effects on tumor promotion, we developed an intraperitoneal mouse xenograft model using ZsGreen fluorescent ER- 2008 and ER+ PEO4 human EOC cells. Tumor growth was quantified by in vivo fluorescent imaging. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4066
Platform:: GPL570
15 Samples

Download data: CEL

Series

Accession:: GSE22600

ID:: 200022600

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 40669.

Ovarian cancer intraperitoneal xenograft model

Analysis of estrogen receptor (ER)+PEO4 or ER-2008 human epithelial ovarian cancer (EOC) cells laser captured from intraperitoneal xenografts of mice treated with estrogen (E2). Menopausal E2 replacement therapy increases risk of ER+ EOC. Results provide insight into E2 effects on tumor promotion.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent, 2 cell type, 2 genotype/variation sets

Platform:: GPL570
Series:: GSE22600
15 Samples

Download data: CEL

DataSet

Accession:: GDS4066

ID:: 4066

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20003187010.

Maintenance of Hormone Responsiveness in Luminal Breast Cancers by Suppression of Notch

(Submitter supplied) Luminal breast cancers express estrogen (ER) and/or progesterone (PR) receptors and respond to hormone therapies. Basal-like “triple negative” (TN) cancers lack steroid receptors but are cytokeratin (CK) 5-positive and require chemotherapy. Here we show that over half of primary ER+PR+ breast cancers contain an ER–PR–CK5+ “luminobasal” subpopulation exceeding 1% of cells. Starting from ER+PR+ luminal cell lines, we generated novel lines with varying luminal to luminobasal-cell ratios and studied their molecular and biological properties. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10481
24 Samples

Download data

Series

Accession:: GSE31870

ID:: 200031870

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002506611.

Genomic predictor of response and survival following neoadjuvant taxane-anthracycline chemotherapy in breast cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
508 Samples

Download data: CEL, TXT

Series

Accession:: GSE25066

ID:: 200025066

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001006112.

Expression data of MCF7 cells following short-term E deprivation, ER-alpha siRNA knockdown and oxidant treatments

(Submitter supplied) To investigate the oxidant sensitivity of E/ER regulated gene expression, E/ER regulated genes are identified using E deprivation or ER-alpha siRNA knockdown; and oxidative stress responsive is determined by 8hr exposure to diamide, hydrogen peroxide and menadione Keywords: biomarker identification

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL3921
12 Samples

Download data: CEL

Series

Accession:: GSE10061

ID:: 200010061

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000819313.

Expression data from age-dichotomized ER+ breast tumors

(Submitter supplied) To investigate the biological basis between aging and sporadic breast cancer incidence and prognosis, RNA samples from matched ER+ invasive breast cancers diagnosed in either young (≤45) or old (≥70) women were analyzed by expression microarrays Keywords: biomarker identification

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4685
47 Samples

Download data: CEL

Series

Accession:: GSE8193

ID:: 200008193

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000737814.

Expression data from age-dichotomized ER+, N0 breast tumors

(Submitter supplied) Signaling pathways that converge on two different transcription factor complexes, NFκB and AP-1, have been identified in estrogen receptor (ER)-positive breast cancers resistant to the antiestrogen, tamoxifen. In this study, biomarkers co-ordinately up-regulated by NFKB and AP-1 with prognositic significance are identified in a largely TAM-treated set of ER+ node negative breast cancers. The prognostic value with respect to age is also investigated. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4685
54 Samples

Download data: CEL

Series

Accession:: GSE7378

ID:: 200007378

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20013987015.

Comparison of MPA regulated gene expression profiles to those regulated by PROG, DHT, DEX

(Submitter supplied) Medroxyprogesterone acetate (MPA) is a progestin that can bind to and activate progesterone, androgen and glucocorticoid receptors. However, it is not known which receptor mediates MPA action in a cellular context where all three of these receptors are co-expressed and functional. This microarray experiment was performed to compare the transcriptomes induced by MPA and the cognate ligands for these receptors ie progesterone (PROG), 5a-dihydrotestosterone (DHT) and dexamethasone (DEX) in breast cancer cells to determine which was most similar to MPA.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16686
15 Samples

Download data: CEL

Series

Accession:: GSE139870

ID:: 200139870

Select item 20006929616.

Active FOXO1 is a Key Determinant of Isoform-Specific Progesterone Receptor Transactivation and Senescence Programming

(Submitter supplied) Progesterone promotes differentiation coupled to proliferation and pro-survival in the breast, but inhibits estrogen-driven growth in the reproductive tract and ovaries. Herein, it is demonstrated, using progesterone receptor (PR) isoform-specific ovarian cancer model systems, that PR-A and PR-B promote distinct gene expression profiles that differ from PR-driven genes in breast cancer cells. In ovarian cancer models, PR-A primarily regulates genes independently of progestin, while PR-B is the dominant ligand-dependent isoform. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
36 Samples

Download data

Series

Accession:: GSE69296

ID:: 200069296

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006929517.

Active FOXO1 is a Key Determinant of Isoform-Specific Progesterone Receptor Transactivation and Senescence Programming

(Submitter supplied) The progesterone receptor specific gene targets were investigated in ovarian and breast cancer cell lines where FOXO1 was found to be a primary factor that cooperates with PR to activate cellular senescence genes (including p21) specifically in ovarian cells. ABSTRACT: Progesterone promotes differentiation coupled to proliferation and pro-survival in the breast, but inhibits estrogen-driven growth in the reproductive tract and ovaries. more...