GEO DataSets

(Submitter supplied) Study was performed in order to determine the type and scope of interferon response of Rousettus aegyptiacus-derived fibroblasts to Sendai virus infection. This study helps to understand the function of the expanded immune repertoire of Rosettus aegyptiacus.

Organism:

Rousettus aegyptiacus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24487

18 Samples

Download data: GFF, H5

(Submitter supplied) Abstract from accompanying publication: "Bats host a number of viruses that cause severe disease in humans without experiencing overt symptoms of disease themselves. While the mechanisms underlying this ability to avoid sickness are not known, deep sequencing studies of bat genomes have uncovered genetic adaptations that may have functional importance in the antiviral response of these animals. Egyptian rousette bats (Rousettus aegyptiacus) are the natural reservoir hosts of Marburg virus (MARV). more...

Organism:

Rousettus aegyptiacus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24487

66 Samples

Download data: TXT

(Submitter supplied) Study was performed in order to determine the scope of antiviral response of Rousettus aegyptiacus-derived fibroblasts to Sendai and Marburg virus infection. This study aids in understanding the function of the expanded immune repertoire of Rosettus aegyptiacus.

Organism:

Rousettus aegyptiacus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24487

36 Samples

Download data: GFF, H5

(Submitter supplied) Deep sequencing of mRNA from Pteropus alecto and Myotis davidii

Organism:

Pteropus alecto; Myotis davidii

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL16126 GPL15898

2 Samples

Download data: FA, WIG

(Submitter supplied) Bats are reservoirs of a number of highly pathogenic human viruses, yet they remain relatively asymptomatic during infection. Whether this viral resistance is due to a unique immune system is unknown. An evolutionarily conserved feature of vertebrate antiviral immunity is the interferon (IFN) response, which triggers cellular defenses through interferon-stimulated gene (ISG) expression. While bats encode an intact IFN system, global ISG expression patterns in bat cells are not well characterized. more...

Organism:

Pteropus alecto

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23872

15 Samples

Download data: TXT

(Submitter supplied) Bats harbor high-impact zoonotic viruses in absence of clinical disease, which has been recently associated with unique features of their immune system. They seem to restrict inflammation and possibly limit disease manifestation to a minimum. In-depth characterization of cellular immunity in bats is yet largely missing, and imprinting of age and development on immune cell compartments remains unexplored. more...

Organism:

Rousettus aegyptiacus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL30616

4 Samples

Download data: MTX, TSV, TXT

(Submitter supplied) Bats harbour various viruses without severe symptoms and act as natural reservoirs. This tolerance of bats toward viral infections is assumed to be originated from the uniqueness of their immune system. However, how the innate immune response varies between primates and bats remains unclear. To illuminate differences in innate immune responses among animal species, we performed a comparative single-cell RNA-sequencing analysis on peripheral blood mononuclear cells (PBMCs) from four species including Egyptian fruit bats inoculated with various infectious stimuli.

Organism:

Macaca mulatta; Homo sapiens; Rousettus aegyptiacus; Pan troglodytes

Type:

Expression profiling by high throughput sequencing

4 related Platforms

16 Samples

Download data: H5

(Submitter supplied) An Infinium microarray platform (GPL28271, HorvathMammalMethylChip40) was used to generate DNA methylation data from several tissues in several bat species. Tissues: skin (wing punches), liver, brain, skeletal muscle.

Organism:

Rousettus aegyptiacus; Desmodus rotundus; Rattus norvegicus; Myotis lucifugus; Rhynchonycteris naso; Pteropus poliocephalus; Pteropus hypomelanus; Phyllostomus hastatus; Eptesicus fuscus; Nyctalus noctula; Cynopterus brachyotis; Rhinolophus ferrumequinum; Myotis vivesi; Artibeus jamaicensis; Antrozous pallidus; Homo sapiens; Mus musculus; Molossus molossus; Nycticeius humeralis; Myotis myotis; Saccopteryx bilineata; Phyllostomus discolor; Pteropus vampyrus; Tadarida brasiliensis; Carollia perspicillata; Eidolon helvum; Pteropus rodricensis; Myotis brandtii; Pteropus giganteus; Pteropus pumilus; Leptonycteris yerbabuenae

Type:

Methylation profiling by array

Platform:

GPL28271

908 Samples

Download data: DOCX, IDAT, TXT