Similar studies for GEO DataSets (Select 200120957) - GEO DataSets

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Items: 20

Select item 2001209571.

The EN1 transcription factor drives neural features and brain metastases in triple negative breats cancer (TNBC)

(Submitter supplied) To define transcriptional dependencies of TNBCs, we identified transcription factors highly and specifically expressed in primary TNBCs and tested their requirement for cell growth in a panel of breast cancer cell lines. We found that EN1 is overexpressed in TNBCs and its downregulation preferentially and significantly reduces cellular viability and tumorigenicity in TNBC cell lines. Based on RNA-seq and ChIPseq we found that EN1 regulates genes involved in angiogenesis, neurogenesis, and axon guidance in breast cancer cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
89 Samples

Download data: BED, CSV

Series

Accession:: GSE120957

ID:: 200120957

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000473582.

Novel role of Engrailed 1 as pro-survival transcription factor in basal-like breast cancer and engineering of interference peptides to block its oncogenic function

(Submitter supplied) Basal-like breast tumors are aggressive cancers associated with high proliferation and metastasis. Currently basal-like breast cancer patients can only be treated with chemotherapy options. However, resistance to chemotherapy often occurs, resulting in recurrence and patient death. Some extremely aggressive basal-like breast cancers are also associated with hypoxia, inflammation and high leukocyte infiltration. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10481
5 Samples

Download data

Series

Accession:: GSE47358

ID:: 200047358

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001103323.

Gene Expression data from SH3GL2 overexpressing SUM-159 cells

(Submitter supplied) SH3GL2 acts as a tumor suppressor. Our aim was to idenfy SH3GL2 regulatory pathways. We stably introduced SH3GL2 in SUM159 cells, exhibiting reduced cancer growth and pulmonary metastasis

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL571
6 Samples

Download data: CEL

Series

Accession:: GSE110332

ID:: 200110332

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000499554.

Genome-wide maps of XBP1 binding sites in different breast cancer cell lines.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11154 GPL570
19 Samples

Download data: BED, BW, CEL

Series

Accession:: GSE49955

ID:: 200049955

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000499535.

Expression data from two breast cancer cell lines

(Submitter supplied) During cancer progression, carcinoma cells encounter a variety of cytotoxic stresses such as hypoxia, nutrient deprivation, and low pH as a result of inadequate vascularization. To maintain survival and growth in the face of these physiologic stressors, a set of adaptive response pathways are induced. One adaptive pathway well studied in other contexts is the unfolded protein response (UPR), of which XBP1 is an important component. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
8 Samples

Download data: CEL

Series

Accession:: GSE49953

ID:: 200049953

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000499526.

Genome-wide maps of XBP1 binding sites in different breast cancer cell lines [ChIP-Seq]

(Submitter supplied) We report the application of ChIP-seq, which combines chromatin immunoprecipitation (ChIP) with massively parallel DNA sequencing, to map genome-wide XBP1 binding sites in different breast cancer cell lines. We showed that HIF1α motif was enriched in XBP1 binding sites in triple negative breast cancer (TNBC) cell lines, but not enriched in ER positive breast cancer cell line. We also demonstrated that different breast cancer cell lines of the same sub-type had similar XBP1 binding sites, whereas different breast cancer sub-types had majorly different XBP1 binding sites. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
11 Samples

Download data: BED, BW

Series

Accession:: GSE49952

ID:: 200049952

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001133627.

Activating Transcription Factor 4 modulated TGFb-induced aggresiveness in triple negative breast cancer vis SMAD2/3/4 and mTORC2 signaling

(Submitter supplied) Based on the identified stress-independent cellular functions of activating transcription factor 4 (ATF4), we reported enhanced ATF4 levels in MCF10A cells treated with TGFβ1. ATF4 is overexpressed in triple negative breast cancer (TNBC) patients, but its impact on patient survival and the underlying mechanisms remain unknown. We aimed to determine ATF4 effects on breast cancer patient survival and TNBC aggressiveness, and the relationships between TGFβ and ATF4.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
20 Samples

Download data: TXT

Series

Accession:: GSE113362

ID:: 200113362

Select item 2000464418.

Insights into the invasiveness of triple negative breast cancer from genome-wide profiling of transcription factor AP-1

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array

Platforms:: GPL9052 GPL11532
14 Samples

Download data: CEL, TXT

Series

Accession:: GSE46441

ID:: 200046441

Select item 2000464409.

Insights into the invasiveness of triple negative breast cancer from genome-wide profiling of transcription factor AP-1 (expression)

(Submitter supplied) Triple negative breast cancer (TNBC) is an aggressive clinical phenotype, and accounts for 15% to 20% of all breast cancers. The molecular determinants of malignant cell behaviors in TNBC remain largely unknown. We find that the AP-1 transcription factor component, Fra-1, is overexpressed in basal-like breast tumors, and its expression level has high prognostic significance. Depletion of Fra-1 or its heterodimeric partner c-Jun inhibits the proliferative and invasive phenotypes in TNBC cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL11532
10 Samples

Download data: CEL

Series

Accession:: GSE46440

ID:: 200046440

Select item 20004616610.

Insights into the invasiveness of triple negative breast cancer from genome-wide profiling of transcription factor AP-1 (ChIP-seq)

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9052
4 Samples

Download data: BED, TXT

Series

Accession:: GSE46166

ID:: 200046166

PubMed Similar studies SRA Run Selector

Select item 20018132211.

Expression data for HMLE-based EMT models

(Submitter supplied) EMT was induced using stable overexpression of 1 of 4 EMT transcription factors (FOXQ1, TWIST1, ZEB2, and SNAI1) in the HMLE cell line. HMLE cells with ectopic LACZ expression were used as control cells.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL23126
5 Samples

Download data: CEL

Series

Accession:: GSE181322

ID:: 200181322

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20018123712.

RNA binding protein RBMS3 is a common effector of EMT program that promotes Triple-Negative Breast Cancer Progression by Regulation of PRRX1 mRNA Stability

(Submitter supplied) The epithelial-to-mesenchymal transition (EMT) has been recognized as a driving force for tumor progression in breast cancer. Recently, our group identified the RNA Binding Motif Single Stranded Interacting Protein 3 (RBMS3) to be significantly associated with an EMT transcriptional program in breast cancer. Additional expression profiling demonstrated that RBMS3 was consistently upregulated by multiple EMT transcription factors and correlated with mesenchymal gene expression in breast cancer cell lines. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
24 Samples

Download data: CSV, SF

Series

Accession:: GSE181237

ID:: 200181237

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20008003813.

The microRNAs with potential in predicting lung metastasis of triple negative breast cancer

(Submitter supplied) To identify lung metastasis associated microRNAs in triple negative breast cancer (TNBC), we have employed the commercially available Agilent Human miRNA V19.0 Microarray (Platform GPL19730) as a discovery platform. In comparison with LM-Normal, 11 microRNAs significantly altered in both LM-Met and LM-Tumor, and then three of them (hsa-miR-21-3p, hsa-miR-21-5p and hsa-miR-211-3p) were excluded, which were also up-regulated in RF-Tumor. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL18044
20 Samples

Download data: TXT

Series

Accession:: GSE80038

ID:: 200080038

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20022880514.

Engrailed-1 Promotes Pancreatic Cancer Metastasis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL24247
48 Samples

Download data: BIGWIG, TXT

Series

Accession:: GSE228805

ID:: 200228805

PubMed Full text in PMC Similar studies

Select item 20022880415.

Engrailed-1 Promotes Pancreatic Cancer Metastasis [RNA-Seq]

(Submitter supplied) Engrailed-1 (EN1) is a critical homeodomain transcription factor (TF) required for neuronal survival, and EN1 expression has been shown to promote aggressive forms of triple negative breast cancer. Here, we report that EN1 is aberrantly expressed in a subset of pancreatic ductal adenocarcinoma (PDA) patients with poor outcomes. EN1 predominantly repressed its target genes through direct binding to gene enhancers and promoters, implicating a role in the cellular response to the stimulation of mesenchymal cell properties. more...