GEO DataSets

(Submitter supplied) To elucidate molecular mechanisms contributing to the disease phenotype in col10a1 medaka (Oryzias latipes) mutants, we isolated col10a1:nlGFP cells from heterozygous col10a1 medaka mutants and wild-type siblings via fluorescence activated cell sorting (FACS) and performed RNA-seq. Comparison of the transcriptome profiles indicated elevated ER stress, dysregulated cell polarity and reduced ECM production in heterozygous col10a1 mutants.

Organism:

Oryzias latipes

Type:

Expression profiling by high throughput sequencing

Platform:

GPL27992

5 Samples

Download data: TXT

(Submitter supplied) We set out to generate transcriptional maps of chondrocyte UPR gene networks in vivo using two mouse models (Schmid and Cog) of Schmid chondrodysplasia, in order to define the consequences of UPR activation for the adaptation, differentiation, and survival of chondrocytes experiencing ER stress during hypertrophy, thus providing insights into ER stress signaling and its impact on cartilage pathophysiology. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

12 Samples

Download data: TXT

(Submitter supplied) Multiple epiphyseal dysplasia (MED) results from mutations in cartilage structural proteins COMP, MATN3 and type IX collage. V194D Matn3 is a mouse model of MED in which a signifficant contribution of ER stress has been detected. In order to test whether ER stress contribution was a beneficial or detrimental component of the disease, V194D Matn3 mice were crossed with a cartilage specific knock-out of Xbp1, and transcriptomic analysis was performed using the Affymetrix 420A Mouse Array.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

4 Samples

Download data: CEL

(Submitter supplied) A global RNA-Seq analysis was conducted using RNA isolated from the axial region of DMSO- and 0.3 nM TCDD-exposed medaka to identify targets within the osteochondral pathway potentially impacted by TCDD exposure. In total, 597 genes were significantly up- or down-regulated (q<0.05) and were associated with select pathological states including inflammatory disease, connective tissue disorders, and skeletal and muscular disorders.

Organism:

Oryzias latipes

Type:

Expression profiling by high throughput sequencing

Platform:

GPL22469

6 Samples

Download data: CSV

(Submitter supplied) In order to identify the effects of the absence of SEDL on Medaka transcriptome, we performed RNAseq experiments Transcriptome analysis of the liver of mice trated with CD95 activating antibody, compared with liver of mice trated with saline.

Organism:

Oryzias latipes

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21753

6 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Oryzias latipes

Type:

Expression profiling by high throughput sequencing

Platform:

GPL27992

6 Samples

Download data: TXT

(Submitter supplied) Transcriptomic profile of Stage 40 Oryzias latipes (Medaka) embryos wild type and KO for SEDL

Organism:

Oryzias latipes

Type:

Expression profiling by high throughput sequencing

Platform:

GPL27992

6 Samples

Download data: TXT

(Submitter supplied) In order to better understand the mechanisms of chondrocyte hypertrophy, we induced hypertrophic chondrocytes from 414C2 iPSCs and analyzed their gene expression profile. This dataset includes the expression data obtained from iPSC-derived sclerotome and cartilage on days -1, 28, and 56 of induction. Day 56 samples were compared to day 28 samples to analyze pathways involved in chondrocyte hypertrophy.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

9 Samples

Download data: CEL

(Submitter supplied) In order to better understand chondrodysplasia disease mechanisms, we induced hypertrophic chondrocytes from chondrodysplasia-specific iPSCs and analyzed their gene expression profile. This dataset includes the expression data obtained from iPSC-derived cartilage pellets on day 56 of hypertrophic induction. Three COL10A1 mutants and two MATN3 mutants were compared to their isogenic controls to determine the effects of each mutation on the unfolded protein response.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

27 Samples

Download data: CEL

(Submitter supplied) Mammalian ATF6α/β are membrane-bound transcription factors which are activated by endoplasmic reticulum (ER) stress-induced proteolysis to upregulate various ER quality control proteins to maintain the homeostasis of the ER. ATF6α- and ATF6β-single knockout mice develop normally but ATF6α/β-double knockout causes embryonic lethality, the reason for which remains unknown. Here, we showed that medaka fish exhibits the same phenotype regarding the effects of deleting ATF6α, ATF6β, and both. more...

Organism:

Oryzias latipes

Type:

Expression profiling by array

Platform:

GPL15425

4 Samples

Download data: TXT