GEO DataSets

Analysis of Saccharomyces cerevisiae mutant cells lacking aminolevulinic acid (ALA) synthase. ALA synthase catalyzes the first step of heme biosynthesis. Heme uptake is induced by heme starvation in S. cerevisiae. Results provide insight into the molecular mechanisms regulating heme uptake.

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array, count, 2 growth protocol sets

Platform:

GPL90

Series:

GSE9514

4 Samples

Download data: CEL

(Submitter supplied) We addressed changes in gene expression profile in response to reduced oxygen tension in wild type or heme depletion caused by deletion of heme biosynthesis gene hem1 Keywords: Response to heme depletion and hypoxia

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array

Datasets:

GDS3437 GDS3438

Platform:

GPL90

8 Samples

Download data: CEL

Analysis of Saccharomyces cerevisiae wild type cells grown under reduced oxygen tension. Heme synthesis requires oxygen, and yeast grown anaerobically exhibit an increased uptake of hemin. Results provide insight into the molecular mechanisms regulating heme uptake.

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array, count, 2 growth protocol sets

Platform:

GPL90

Series:

GSE9514

4 Samples

Download data: CEL

(Submitter supplied) To test the effect of hemin and of HAP1 in C. albicans, a hap1 mutant and it's reintegrant (wild-type) strain were grown in YPD to log phase, and then exposed or not to 50 microM hemin for 30'.

Organism:

Candida albicans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL32241

12 Samples

Download data: CSV

(Submitter supplied) Sampangine, a plant-derived alkaloid found in the Annonaceae family, exhibits strong inhibitory activity against the opportunistic fungal pathogens Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus. In the present study, transcriptional profiling experiments coupled with the analysis of mutants were performed in an effort to elucidate its mechanism of action. Using Saccharomyces cerevisiae as a model organism, we show that sampangine produces a transcriptional response indicative of hypoxia, altering the expression of genes known to respond to low oxygen conditions. more...

Organism:

Saccharomyces cerevisiae; Candida albicans

Type:

Expression profiling by array

Platforms:

GPL6346 GPL90

9 Samples

Download data: CEL, TXT

(Submitter supplied) Sampangine, a plant-derived alkaloid found in the Annonaceae family, exhibits strong inhibitory activity against the opportunistic fungal pathogens Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus. In the present study, transcriptional profiling experiments coupled with the analysis of mutants were performed in an effort to elucidate its mechanism of action. Using Saccharomyces cerevisiae as a model organism, we show that sampangine produces a transcriptional response indicative of hypoxia, altering the expression of genes known to respond to low oxygen conditions. more...

Organism:

Candida albicans

Type:

Expression profiling by array

Platform:

GPL6346

3 Samples

Download data: TXT

(Submitter supplied) Sampangine, a plant-derived alkaloid found in the Annonaceae family, exhibits strong inhibitory activity against the opportunistic fungal pathogens Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus. In the present study, transcriptional profiling experiments coupled with the analysis of mutants were performed in an effort to elucidate its mechanism of action. Using Saccharomyces cerevisiae as a model organism, we show that sampangine produces a transcriptional response indicative of hypoxia, altering the expression of genes known to respond to low oxygen conditions. more...

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array

Dataset:

GDS3137

Platform:

GPL90

6 Samples

Download data: CEL

(Submitter supplied) The C. albicans Genome Oligo Set consisting of 70mer probes representing 6266 C. albicans genes was obtained from Qiagen (Valencia, CA), and printed on glass slides by Microarrays, Inc (Nashville, TN).

Organism:

Candida albicans

2 Series

3 Samples

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Analysis of Saccharomyces cerevisiae cells treated with the antifungal compound sampangine. Sampangine exhibits strong inhibitory activity against opportunistic fungal pathogens such as Candida albicans. Using S. cerevisiae as a model, results provide insight into sampangine's mechanism of action.

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL90

Series:

GSE10073

6 Samples

Download data: CEL

(Submitter supplied) Yeast S. cerevisiae microarrays from the SGDB (Ecole Normale Superieure, Paris, France). Yeast ORFs are deposited in duplicate (double genome). Probes are oligonucleotides (40mers) from the Yeast oligoset distributed by MWG Biotech. Keywords = yeast Keywords = transcriptome

Organism:

Saccharomyces cerevisiae

2 Series

5 Samples

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(Submitter supplied) Analysis of iron-regulated gene expression in Saccharomyces cerevisiae using cDNA microarrays has identified three putative cell wall proteins that are directly regulated by Aft1p, the major iron-dependent transcription factor in yeast. FIT1, FIT2, and FIT3 (for facilitator of iron transport) were more highly expressed in strains grown in low concentrations of iron and in strains in which AFT1-1(up), a constitutively active allele of AFT1, was expressed. more...

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array

Platforms:

GPL59 GPL58

4 Samples

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(Submitter supplied) Heme Deficient or Wild Type (normal heme) for 6 hrs with iron chelation by BPS. Keywords: Cell Type Comparison

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array

Platform:

GPL2983

4 Samples

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