Similar studies for GEO DataSets (Select 3895) - GEO DataSets

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Items: 17

Select item 38951.

BPH/J2 model of neurogenic hypertension: hypothalamus

Analysis of hypothalamus from young (6 week-old) and adult (26 week-old) BPH/2J hypertensive males and age-/gender-matched normotensive BPN/3J controls. Results provide insight into molecular mechanisms underlying early and established neurogenic hypertension in hypothalamus.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 age, 2 disease state, 2 strain sets

Platform:: GPL6246
Series:: GSE25076
24 Samples

Download data: CEL

DataSet

Accession:: GDS3895

ID:: 3895

Select item 2000250762.

Hypothalamic expression differences between hypertensive BPH/2J and normotensive BPN/3J mouse strains

(Submitter supplied) Identification of hypothalamic genes whose expression differs between high blood pressure (BPH/2J) and normal blood pressure (BPN/3J) Schlager mouse strains at age 6 weeks (young) and 26 weeks (mature) using Affymetrix GeneChip® Mouse Gene 1.0 ST Arrays.

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3895
Platform:: GPL6246
24 Samples

Download data: CEL

Series

Accession:: GSE25076

ID:: 200025076

Select item 2000016753.

SHR and WKY rat adrenal glands

(Submitter supplied) We measured gene expression in the adrenal glands of the Spontaneously Hypertensive Rat (SHR) and Wistar-Kyoto rat (WKY) using Affymetrix RG-U34A GeneChips. All rats were aged-matched at 4-weeks. The rats were obtained from the colonies at the Univeristy of California San Diego, La Jolla, CA. Keywords: other

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS1464
Platform:: GPL85
6 Samples

Download data: CEL, EXP

Series

Accession:: GSE1675

ID:: 200001675

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000016744.

BPH and BPL mouse strain adrenal glands

(Submitter supplied) We performed Affymetrix MG-U74Av2 GeneChip experiements on mRNA from the adrenal glands of the BPH hypertensive and BPL hypotensive mouse strains. All mice were aged-matched at 5 weeks. We obtained the mice from Jackson Laboratories, Bar Harbor, ME. Keywords: other

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS1011
Platform:: GPL81
6 Samples

Download data: CEL, EXP

Series

Accession:: GSE1674

ID:: 200001674

Select item 14645.

Essential hypertension SHR model

Comparison of adrenal gland from spontaneously hypertensive (SHR) males at 4 weeks of age, a prehypertensive stage, and normotensive Wistar-Kyoto. Results compared to gene expression in hypertensive BPH mouse model, and provides insight into mechanisms of hypertension shared across species.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 disease state sets

Platform:: GPL85
Series:: GSE1675
6 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS1464

ID:: 1464

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 10116.

Essential hypertension BPH model

Expression profiling of adrenal glands from blood pressure high (BPH) males at the prehypertensive stage. BPH males examined at 5 weeks of age. Results compared to gene expression in SHR rat model, and provides insight into mechanisms of hypertension shared across species.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 disease state, 2 strain sets

Platform:: GPL81
Series:: GSE1674
6 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS1011

ID:: 1011

Select item 2000260077.

Hypothalamic expression differences between hypertensive BPH/2J during circadian variations of blood pressure

(Submitter supplied) Identification of hypothalamic genes whose expression differs between active (peak of blood pressure) and inactive periods in the high blood pressure (BPH/2J) Schlager mouse, adjusted by their age- and activity-matched normal blood pressure (BPN/3J) controls using Affymetrix GeneChip® Mouse Gene 1.0 ST Arrays.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
18 Samples

Download data: CEL

Series

Accession:: GSE26007

ID:: 200026007

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000540158.

Expression data from male and female Schlager hypertensive (BPH/2J) and normotensive (BPN/3J) kidneys

(Submitter supplied) Analysis of kidneys from 12 week BPH/2J hypertensive and age matched normotensive BPN/3J controls - males and females. The results provide insights into the genes that are involved in hypertension in both males and females, as well as highlight mechanisms that underlye sex differences in hypertension. We show that female data can be used to refine candidate genes and pathways, as well as highlight potential mechanisms to explain the differences in prevalence and severity of disease between the sexes.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11533
24 Samples

Download data: CEL

Series

Accession:: GSE54015

ID:: 200054015

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000016229.

Transcriptional profiling with a Blood Pressure QTL interval-specific oligonucleotide array

(Submitter supplied) Although the evidence for a genetic predisposition to human essential hypertension is compelling, the genetic control of blood pressure (BP) is poorly understood. The Dahl salt-sensitive (S) rat is a model for studying the genetic component of BP. Using this model we previously reported the identification of 16 different genomic regions that contain one or more BP quantitative trait loci (QTLs). The proximal region of rat chromosome 1 contains multiple BP QTLs. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platforms:: GPL1350 GPL2796
19 Samples

Download data

Series

Accession:: GSE1622

ID:: 200001622

Select item 20001074810.

Expression data from brain tissue of Rattus norvegicus treated with D-Serine

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS3643
Platform:: GPL1355
24 Samples

Download data: CEL

Series

Accession:: GSE10748

ID:: 200010748

Select item 364311.

D-serine effect on the brain: dose response

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 agent, 6 dose sets

Platform:: GPL1355
Series:: GSE10748
24 Samples

Download data: CEL

DataSet

Accession:: GDS3643

ID:: 3643

Select item 20003337212.

Hypothalamic gene expression profile indicates a reduction in G-protein signaling in the wfs1 mutant mice

(Submitter supplied) WFS1 gene is coding protein with unknown function but its functional deficiency causes different neuropsychiatric and neuroendocrine syndromes. In the present study we aimed to find the functional networks influenced by the Wfs1 deficiency in the hypothalamus. We performed gene expression profiling (Mouse Gene 1.0 ST Arrays) in Wfs1 deficient mice (ko). Modified t-statistics was used for comparison of groups (wt vs ko). more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4526
Platform:: GPL6246
18 Samples

Download data: CEL

Series

Accession:: GSE33372

ID:: 200033372

Select item 452613.

Wfs1 deficiency model of Wolfram syndrome: hypothalamus

Analysis of hypothalami from Wfs1-knockout, 129SV animals. Wfs1 deletion models Wolfram syndrome (WS), an autosomal recessive disorder characterized by multiple endocrine failure. Results provide insight into the molecular mechanisms underlying WS.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:: GPL6246
Series:: GSE33372
18 Samples

Download data: CEL

DataSet

Accession:: GDS4526

ID:: 4526

Select item 20005083314.

Analysis of age-related vascular gene expression in mice

(Submitter supplied) Analyses of the age-related changes that occur at a gene expression level and transcriptional profile have not been elucidated in depth. To determine the changes of the vascular transcriptome, we conducted gene expression microarray experiments on aortas of adult and old mice, in which age-related vascular dysfunction was confirmed by increased stiffness and associated systolic hypertension

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10787
12 Samples

Download data: TXT

Series

Accession:: GSE50833

ID:: 200050833

Select item 20001934215.

Adrenal gland gene expression from adult (12-week old) hypertensive BPH and adult (12-week old) hypotensive BPL mice

(Submitter supplied) The objective of the experiment is to determine the genes differentially expressed in the adrenal gland of adult (12-week) BPH and BPL mice.

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3777
Platform:: GPL81
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE19342

ID:: 200019342

Select item 377716.

BPH model of hypertension: adrenal gland

Analysis of adrenal glands from genetically/hereditary hypertensive (BPH/2) and genetically/hereditary low-blood pressure (BPL/1) 12-week old adults. Results provide insight into molecular mechanisms underlying the pathogenesis of genetic hypertension.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 strain sets

Platform:: GPL81
Series:: GSE19342
6 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS3777

ID:: 3777

Select item 20011115917.

Tissue-specific features of oxidative stress-associated gene expression in a healthy mouse model

(Submitter supplied) Oxidative stress is a common phenomenon and is linked to a wide range of diseases and pathological processes. Tissue-specific variation in redox signaling and cellular responses to oxidative stress may be associated with vulnerability to toxic agents and carcinogenic exposures. In order to provide a basis for tissue-specific difference, we examined the tissue-specific transcriptional features of 101 oxidative stress-associated genes in 10 different tissues and organs of healthy mice under physiological conditions. more...