GEO DataSets

Temporal analysis of liver from macaques infected with virulent lymphocytic choriomeningitis virus (LCMV)-WE or with non-virulent LCMV-Armstrong. LCMV-WE-infected macaques develop viral hemorrhagic fever similar to human Lassa fever. Results provide insight into molecular basis of LCMV pathogenesis.

Organism:

Macaca mulatta; Homo sapiens

Type:

Expression profiling by array, transformed count, 3 disease state, 4 infection, 11 time sets

Platform:

GPL570

Series:

GSE12254

20 Samples

Download data: CEL

(Submitter supplied) Rhesus macaques (Macaca mulatta) infected with a lethal dose of lymphocytic choriomeningitis virus-strain WE (LCMV-WE) provide a model for Lassa fever virus infection of man. Like Lassa fever in human beings, disease begins with flu-like symptoms but can progress to morbidity fairly rapidly. Previously, we profiled the blood transcriptome of LCMV-infected monkeys (M. Djavani et al. J. Virol. 2007: PMID 17522210) showing distinct pre-viremic and viremic stages that discriminated between virulent and benign infections. more...

Organism:

Macaca mulatta; Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4161

Platform:

GPL570

20 Samples

Download data: CEL

(Submitter supplied) Lassa fever virus is a zoonotic pathogen that plagues the endemic areas of West Africa. Rhesus macaques infected with a related arenavirus, LCMV-WE, serve as a model for Lassa-infection of human beings. Using a dose similar to that expected from a needle-stick, monkeys experience an early pre-viremic phase (day 1-3), a viremic phase with febrile onset (day 4-7), and, like human beings who succumb, they die within two weeks. more...

Organism:

Macaca mulatta; Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

24 Samples

Download data: CEL

(Submitter supplied) Microarray analysis of PBMC from cynomolgus macaques collected longitudinally over the course of infection with Lassa-Josiah, Lassa-Z132, Lassa-SorombaR, or Lujo viruses (n=3 animals/infection condition).

Organism:

Macaca mulatta; Macaca fascicularis

Type:

Expression profiling by array

Platform:

GPL14569

61 Samples

Download data: TXT

(Submitter supplied) Immune response to infection involves the regulation of numerouse genes in numerous cell types. The number and type of genes that become differentially expressed in response to infection can result in very different pathophysiologic presentations and disease course. Wild type YFV and 17D despite having very few genetic differences result in very different disease outcomes in human and monkey hosts. We used microarrays to detail the global programme of gene expression of Rhesus macaque immune cells responding to both wild type and 17D strains of YFV. We identified distinct classes of gene expression as well as marked differences in differential gene expression between responses to 17D and wild type strains of YFV.

Organism:

Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL3535

12 Samples

Download data: CEL

(Submitter supplied) We report that cells infected with the prototypic arenavirus LCMV are continiously cleared from the infection in a non-cytolytic manner. Non-cytolytic clearance of murine hepatocytes goes along with profound alterations in gene expression.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

19 Samples

Download data: TSV