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Crtac1 cartilage acidic protein 1 [ Mus musculus (house mouse) ]

Gene ID: 72832, updated on 14-Jan-2025

Summary

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Official Symbol
Crtac1provided by MGI
Official Full Name
cartilage acidic protein 1provided by MGI
Primary source
MGI:MGI:1920082
See related
Ensembl:ENSMUSG00000042401 AllianceGenome:MGI:1920082
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lotus; Crtac1B; 2810454P21Rik
Summary
Predicted to enable calcium ion binding activity. Involved in regulation of synapse assembly. Acts upstream of or within axonal fasciculation and olfactory bulb development. Located in growth cone. Is active in glutamatergic synapse and postsynaptic density. Is expressed in central nervous system; dorsal root ganglion; semicircular canal epithelium; tooth; and vibrissa. Orthologous to human CRTAC1 (cartilage acidic protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in frontal lobe adult (RPKM 14.7), cortex adult (RPKM 11.4) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Crtac1 in Genome Data Viewer
Location:
19 C3; 19 36.07 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (42271474..42421405, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (42283035..42432966, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene golgin A7B Neighboring gene STARR-seq mESC enhancer starr_46179 Neighboring gene predicted gene, 34347 Neighboring gene microRNA 3085 Neighboring gene STARR-seq mESC enhancer starr_46182 Neighboring gene STARR-seq mESC enhancer starr_46183 Neighboring gene STARR-seq mESC enhancer starr_46184 Neighboring gene predicted gene, 41848 Neighboring gene STARR-seq mESC enhancer starr_46185 Neighboring gene predicted gene, 34299 Neighboring gene predicted gene, 41849 Neighboring gene predicted gene, 41850

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LOTUS overexpression via ex vivo gene transduction further promotes recovery of motor function following human iPSC-NS/PC transplantation for contusive spinal cord injury. Ito S, et al. Stem Cell Reports, 2021 Nov 9. PMID 34653401, Free PMC Article
  2. Blockade of chondroitin sulfate proteoglycans-induced axonal growth inhibition by LOTUS. Kurihara Y, et al. Neuroscience, 2017 Jul 25. PMID 28571719
  3. The Soluble Form of LOTUS inhibits Nogo Receptor-Mediated Signaling by Interfering with the Interaction Between Nogo Receptor Type 1 and p75 Neurotrophin Receptor. Kawakami Y, et al. J Neurosci, 2018 Mar 7. PMID 29440387, Free PMC Article
  4. LOTUS, an endogenous Nogo receptor antagonist, is involved in synapse and memory formation. Nishida R, et al. Sci Rep, 2021 Mar 3. PMID 33658590, Free PMC Article
  5. The soluble form of LOTUS inhibits Nogo receptor type 1-mediated signaling induced by B lymphocyte stimulator and chondroitin sulfate proteoglycans. Kawakami Y, et al. Neurosci Lett, 2018 Sep 14. PMID 29953923

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LOTUS suppresses amyloid beta-induced dendritic spine elimination through the blockade of amyloid beta binding to PirB.
    Title: LOTUS suppresses amyloid β-induced dendritic spine elimination through the blockade of amyloid β binding to PirB.
  2. LOTUS overexpression via ex vivo gene transduction further promotes recovery of motor function following human iPSC-NS/PC transplantation for contusive spinal cord injury.
    Title: LOTUS overexpression via ex vivo gene transduction further promotes recovery of motor function following human iPSC-NS/PC transplantation for contusive spinal cord injury.
  3. LOTUS, an endogenous Nogo receptor antagonist, is involved in synapse and memory formation.
    Title: LOTUS, an endogenous Nogo receptor antagonist, is involved in synapse and memory formation.
  4. The neuronal overexpression of LOTUS in transgenic mice promotes motor recovery after spinal cord injury, and recombinant viral overexpression of LOTUS enhances retinal ganglion cell axonal regeneration after optic nerve crush. Thus, the level of LOTUS function titrates axonal regeneration.
    Title: Regulation of axonal regeneration by the level of function of the endogenous Nogo receptor antagonist LOTUS.
  5. Genetic deletion of Crtac1 significantly inhibited cartilage degradation, osteophyte formation and gait abnormalities of post-traumatic OA in female, but not male, animals undergoing the destabilization of medial meniscus (DMM) surgery.
    Title: Sex-Specific Protection of Osteoarthritis by Deleting Cartilage Acid Protein 1.
  6. These data suggest that LOTUS functions as a potent endogenous antagonist for NgR1 when bound by all four known NgR1 ligands.
    Title: LOTUS suppresses axon growth inhibition by blocking interaction between Nogo receptor-1 and all four types of its ligand.
  7. These findings suggest that the UA/EC region is a functional domain of LOTUS serving for an antagonistic action to NgR1.
    Title: The carboxyl-terminal region of Crtac1B/LOTUS acts as a functional domain in endogenous antagonism to Nogo receptor-1.
  8. found CRTAC1-B(LOTUS)is key molecule for lateral olfactory tract(LOT)formation; NgR1 is LOTUS-binding protein;LOTUS suppressed Nogo-NgR1 binding and Nogo-induced growth cone collapse;suggest endogenous antagonism of NgR1 by LOTUS crucial for LOT formation
    Title: Cartilage acidic protein-1B (LOTUS), an endogenous Nogo receptor antagonist for axon tract formation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axonal fasciculation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within axonal fasciculation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within olfactory bulb development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cartilage acidic protein 1
Names
68 kDa chondrocyte-expressed protein
ASPIC
CEP-68
protein CRTAC1-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356588.1 → NP_001343517.1  cartilage acidic protein 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC119236, AC144792, AL603804
    UniProtKB/TrEMBL
    A0A571BE99
    Conserved Domains (3) summary
    pfam07593
    Location:455 → 507
    UnbV_ASPIC; ASPIC and UnbV
    pfam07645
    Location:554 → 600
    EGF_CA; Calcium-binding EGF domain
    pfam13517
    Location:294 → 358
    VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

  2. NM_001356589.1 → NP_001343518.1  cartilage acidic protein 1 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1
    Source sequence(s)
    AK032328, AK083221, AK149020, AK149069
    UniProtKB/TrEMBL
    A0A571BE99
    Related
    ENSMUSP00000158623.2, ENSMUST00000238290.2
    Conserved Domains (3) summary
    pfam07593
    Location:461 → 513
    UnbV_ASPIC; ASPIC and UnbV
    pfam07645
    Location:560 → 606
    EGF_CA; Calcium-binding EGF domain
    pfam13517
    Location:300 → 364
    VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

  3. NM_145123.5 → NP_660105.3  cartilage acidic protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_660105.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1)
    Source sequence(s)
    AK032328, AK149020, AK149069
    Consensus CDS
    CCDS29828.1
    UniProtKB/Swiss-Prot
    Q3UF32, Q3UF40, Q8BMF1, Q8R3V8, Q8R555
    UniProtKB/TrEMBL
    A0A571BE99
    Related
    ENSMUSP00000044858.7, ENSMUST00000048630.8
    Conserved Domains (3) summary
    pfam07593
    Location:461 → 513
    UnbV_ASPIC; ASPIC and UnbV
    pfam07645
    Location:560 → 606
    EGF_CA; Calcium-binding EGF domain
    pfam13517
    Location:300 → 364
    VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    42271474..42421405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251093.1 → XP_030106953.1  cartilage acidic protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A571BE99
    Conserved Domains (2) summary
    pfam07593
    Location:461 → 513
    UnbV_ASPIC; ASPIC and UnbV
    pfam13517
    Location:300 → 364
    VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

  2. XM_006527372.4 → XP_006527435.1  cartilage acidic protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A571BE99
    Conserved Domains (3) summary
    pfam07645
    Location:560 → 606
    EGF_CA; Calcium-binding EGF domain
    pfam07593
    Location:461 → 513
    UnbV_ASPIC; ASPIC and UnbV
    pfam13517
    Location:300 → 364
    VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

  3. XM_030251090.2 → XP_030106950.1  cartilage acidic protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A571BE99
    Conserved Domains (2) summary
    pfam07593
    Location:455 → 507
    UnbV_ASPIC; ASPIC and UnbV
    pfam13517
    Location:294 → 358
    VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

  4. XM_030251091.2 → XP_030106951.1  cartilage acidic protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A571BE99
    Conserved Domains (2) summary
    pfam07593
    Location:455 → 507
    UnbV_ASPIC; ASPIC and UnbV
    pfam13517
    Location:294 → 358
    VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

  5. XM_006527369.4 → XP_006527432.2  cartilage acidic protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A571BE99
    Conserved Domains (3) summary
    pfam07645
    Location:554 → 600
    EGF_CA; Calcium-binding EGF domain
    pfam07593
    Location:455 → 507
    UnbV_ASPIC; ASPIC and UnbV
    pfam13517
    Location:294 → 358
    VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

  6. XM_030251092.2 → XP_030106952.1  cartilage acidic protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A571BE99
    Conserved Domains (2) summary
    pfam07593
    Location:455 → 507
    UnbV_ASPIC; ASPIC and UnbV
    pfam13517
    Location:294 → 358
    VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

  7. XM_006527371.4 → XP_006527434.2  cartilage acidic protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A571BE99
    Conserved Domains (3) summary
    pfam07645
    Location:554 → 600
    EGF_CA; Calcium-binding EGF domain
    pfam07593
    Location:455 → 507
    UnbV_ASPIC; ASPIC and UnbV
    pfam13517
    Location:294 → 358
    VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

  8. XM_030251094.2 → XP_030106954.1  cartilage acidic protein 1 isoform X9

    Conserved Domains (3) summary
    pfam07645
    Location:237 → 283
    EGF_CA; Calcium-binding EGF domain
    pfam07593
    Location:138 → 190
    UnbV_ASPIC; ASPIC and UnbV
    pfam13517
    Location:30 → 100
    VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

  9. XM_030251089.2 → XP_030106949.1  cartilage acidic protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A571BE99
    Conserved Domains (2) summary
    pfam07593
    Location:455 → 507
    UnbV_ASPIC; ASPIC and UnbV
    pfam13517
    Location:294 → 358
    VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R555.1 GenPept UniProtKB/Swiss-Prot:Q8R555

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