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    GPR156 G protein-coupled receptor 156 [ Homo sapiens (human) ]

    Gene ID: 165829, updated on 26-Nov-2024

    Summary

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    Official Symbol
    GPR156provided by HGNC
    Official Full Name
    G protein-coupled receptor 156provided by HGNC
    Primary source
    HGNC:HGNC:20844
    See related
    Ensembl:ENSG00000175697 MIM:610464; AllianceGenome:HGNC:20844
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PGR28; GABABL; DFNB121
    Summary
    G protein-coupled receptors (GPCRs) are a large superfamily of cell surface receptors characterized by 7 helical transmembrane domains, together with N-terminal extracellular and C-terminal intracellular domains.[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in testis (RPKM 1.8), ovary (RPKM 0.3) and 7 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPR156 in Genome Data Viewer
    Location:
    3q13.33
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (120165478..120285222, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (122885139..123004744, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (119884325..120004069, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 762, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 397, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:119863928-119865127 Neighboring gene uncharacterized LOC105374065 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:119889176-119889400 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:119961559-119962758 Neighboring gene uncharacterized LOC124909418 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:120032196-120032799 Neighboring gene PTOV1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20331 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14635 Neighboring gene leucine rich repeat containing 58

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Novel GPR156 variants confirm its role in moderate sensorineural hearing loss. Ramzan M, et al. Sci Rep, 2023 Oct 9. PMID 37814107, Free PMC Article
    2. Molecular cloning and characterisation of a novel GABAB-related G-protein coupled receptor. Calver AR, et al. Brain Res Mol Brain Res, 2003 Feb 20. PMID 12591167
    3. Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. Fu GK, et al. Genomics, 2004 Jul. PMID 15203218
    4. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article
    5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Shimada M, et al. Hum Genet, 2010 Oct. PMID 20677014

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Novel GPR156 variants confirm its role in moderate sensorineural hearing loss.
      Title: Novel GPR156 variants confirm its role in moderate sensorineural hearing loss.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Hearing loss, autosomal recessive 121
    MedGen: C5882709 OMIM: 620551 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled GABA receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gamma-aminobutyric acid signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in stereocilium bundle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of G protein-coupled receptor heterodimeric complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 156
    Names
    G protein-coupled receptor PGR28
    GABAB-related G-protein coupled receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168271.2 → NP_001161743.1  probable G-protein coupled receptor 156 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC063952, AC092897, AI201720, BC143606, BX115336, CD638213
      Consensus CDS
      CCDS54629.1
      UniProtKB/Swiss-Prot
      Q8NFN8
      Related
      ENSP00000418758.1, ENST00000461057.1
      Conserved Domains (1) summary
      pfam00003
      Location:71 → 308
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

    2. NM_153002.3 → NP_694547.2  probable G-protein coupled receptor 156 isoform 1

      See identical proteins and their annotated locations for NP_694547.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC063952, AC092897, AF488739, AI201720, BX115336, CD638213
      Consensus CDS
      CCDS2997.1
      UniProtKB/Swiss-Prot
      B7ZL66, E9PFZ4, Q14CM1, Q86SN6, Q8NFN8
      Related
      ENSP00000417261.1, ENST00000464295.6
      Conserved Domains (1) summary
      pfam00003
      Location:71 → 312
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      120165478..120285222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017005796.2 → XP_016861285.1  probable G-protein coupled receptor 156 isoform X1

      UniProtKB/Swiss-Prot
      B7ZL66, E9PFZ4, Q14CM1, Q86SN6, Q8NFN8
      Conserved Domains (1) summary
      pfam00003
      Location:71 → 312
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

    2. XM_017005795.2 → XP_016861284.1  probable G-protein coupled receptor 156 isoform X1

      UniProtKB/Swiss-Prot
      B7ZL66, E9PFZ4, Q14CM1, Q86SN6, Q8NFN8
      Conserved Domains (1) summary
      pfam00003
      Location:71 → 312
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

    3. XM_011512487.2 → XP_011510789.1  probable G-protein coupled receptor 156 isoform X2

      See identical proteins and their annotated locations for XP_011510789.1

      Conserved Domains (1) summary
      pfam00003
      Location:1 → 231
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

    4. XM_047447586.1 → XP_047303542.1  probable G-protein coupled receptor 156 isoform X2

    5. XM_011512488.3 → XP_011510790.1  probable G-protein coupled receptor 156 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      122885139..123004744 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345481.1 → XP_054201456.1  probable G-protein coupled receptor 156 isoform X1

    2. XM_054345482.1 → XP_054201457.1  probable G-protein coupled receptor 156 isoform X1

    3. XM_054345483.1 → XP_054201458.1  probable G-protein coupled receptor 156 isoform X2

    4. XM_054345484.1 → XP_054201459.1  probable G-protein coupled receptor 156 isoform X2

    5. XM_054345485.1 → XP_054201460.1  probable G-protein coupled receptor 156 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NFN8.2 GenPept UniProtKB/Swiss-Prot:Q8NFN8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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