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    PDPN podoplanin [ Homo sapiens (human) ]

    Gene ID: 10630, updated on 27-Nov-2024

    Summary

    Official Symbol
    PDPNprovided by HGNC
    Official Full Name
    podoplaninprovided by HGNC
    Primary source
    HGNC:HGNC:29602
    See related
    Ensembl:ENSG00000162493 MIM:608863; AllianceGenome:HGNC:29602
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    T1A; GP36; GP40; Gp38; OTS8; T1A2; TI1A; D2-40; T1A-2; AGGRUS; HT1A-1; PA2.26
    Summary
    This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in placenta (RPKM 41.5), urinary bladder (RPKM 20.1) and 13 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PDPN in Genome Data Viewer
    Location:
    1p36.21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (13583757..13617957)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (13025717..13059901)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (13910252..13944452)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 38 Neighboring gene uncharacterized LOC107984918 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:13848024-13849223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 214 Neighboring gene bromodomain and WD repeat domain containing 1 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:13910230-13910768 Neighboring gene RNA, 5S ribosomal pseudogene 41 Neighboring gene uncharacterized LOC105378612

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables chemokine binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT enables folic acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-folding chaperone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT enables water channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT enables water transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in actin-mediated cell contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT involved_in amino acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT involved_in folic acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lung development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lymph node development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lymphangiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lymphatic endothelial cell fate commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in platelet activation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of epithelial to mesenchymal transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of extracellular matrix disassembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of platelet aggregation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of platelet aggregation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of platelet aggregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of lamellipodium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of myofibroblast contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of substrate adhesion-dependent cell spreading ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT involved_in water transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in wound healing, spreading of cells IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
     
    located_in cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in filopodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in filopodium membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lamellipodium membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in leading edge of lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microvillus membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in ruffle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in ruffle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in tetraspanin-enriched microdomain IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    podoplanin
    Names
    PA2.26 antigen
    T1-alpha
    glycoprotein 36
    glycoprotein, 36-KD
    hT1alpha-1
    hT1alpha-2
    lung type I cell membrane associated glycoprotein
    lung type-I cell membrane-associated glycoprotein (T1A-2)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006624.2NP_001006625.1  podoplanin isoform c

      See identical proteins and their annotated locations for NP_001006625.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (c) has a shorter N-terminus when compared to isoform a.
      Source sequence(s)
      AF390106, AK075327, AK075345, AL354712, AW022996, AY194238, BC014668, BF340649, BQ212176, BQ214601
      Consensus CDS
      CCDS44060.1
      UniProtKB/Swiss-Prot
      Q86YL7
      Related
      ENSP00000427537.1, ENST00000487038.5
      Conserved Domains (1) summary
      pfam05808
      Location:1119
      Podoplanin; Podoplanin
    2. NM_001006625.2NP_001006626.1  podoplanin isoform d

      See identical proteins and their annotated locations for NP_001006626.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), contains a distinct 5' UTR and has multiple differences in the coding region, compared to variant 1. The resulting isoform (d) is shorter and has a shorter N-terminus when compared to isoform a.
      Source sequence(s)
      AF390106, AK075327, AK075345, AL354712, AW022996, AY194238, BC014668, BF340649, BQ212176, BQ214601
      Consensus CDS
      CCDS53270.1
      UniProtKB/Swiss-Prot
      Q86YL7
      Related
      ENSP00000426063.1, ENST00000475043.5
      Conserved Domains (1) summary
      pfam05808
      Location:1117
      Podoplanin
    3. NM_001385053.1NP_001371982.1  podoplanin isoform d

      Status: REVIEWED

      Source sequence(s)
      AL354712, AL359771
      Consensus CDS
      CCDS53270.1
      Conserved Domains (1) summary
      pfam05808
      Location:1117
      Podoplanin
    4. NM_006474.5NP_006465.4  podoplanin isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AL354712, AL359771, AY194238
      Consensus CDS
      CCDS30602.2
      UniProtKB/Swiss-Prot
      A9Z1Y2, B2R6J8, E9PB68, F6QWX5, O60836, O95128, Q7L375, Q86YL7, Q8NBQ8, Q8NBR3
      UniProtKB/TrEMBL
      H0YA72
      Related
      ENSP00000478125.1, ENST00000621990.5
      Conserved Domains (1) summary
      pfam05808
      Location:28161
      Podoplanin
    5. NM_198389.2NP_938203.2  podoplanin isoform b

      See identical proteins and their annotated locations for NP_938203.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AF390106, AK075327, AK075345, AW022996, AY194238, BC014668, BE887331, BF340649
      Consensus CDS
      CCDS41266.1
      UniProtKB/Swiss-Prot
      Q86YL7
      Related
      ENSP00000365225.4, ENST00000376057.8
      Conserved Domains (1) summary
      pfam05808
      Location:77235
      Podoplanin; Podoplanin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      13583757..13617957
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451404.2XP_024307172.1  podoplanin isoform X1

      Conserved Domains (1) summary
      pfam05808
      Location:1119
      Podoplanin; Podoplanin
    2. XM_006710295.2XP_006710358.1  podoplanin isoform X1

      See identical proteins and their annotated locations for XP_006710358.1

      UniProtKB/Swiss-Prot
      Q86YL7
      Related
      ENSP00000365229.4, ENST00000376061.8
      Conserved Domains (1) summary
      pfam05808
      Location:1119
      Podoplanin; Podoplanin
    3. XM_047434471.1XP_047290427.1  podoplanin isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      13025717..13059901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333893.1XP_054189868.1  podoplanin isoform X1

    2. XM_054333896.1XP_054189871.1  podoplanin isoform X2

    3. XM_054333895.1XP_054189870.1  podoplanin isoform X1

    4. XM_054333894.1XP_054189869.1  podoplanin isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_013317.1: Suppressed sequence

      Description
      NM_013317.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.