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| Status |
Public on Jun 25, 2019 |
| Title |
HDL protects against myocardial ischemia reperfusion injury via miR-34b and miR-337 expression which requires STAT3 |
| Platform organism |
synthetic construct |
| Sample organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by array
|
| Summary |
We investigated whether the cardioprotective effect of HDL modulates miRNAs as a downstream target of STAT3 activation.
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| Overall design |
miRNAs profile was analysed by microarray. The analysis was divided in 6 groups: 3 experimental protocols (sham=no ischemia, IR=ischemia reperfusion protocol and IR+HDL= ischemia reperfusion protocol, treated with HDL at the onset of reperfusion) and 2 mouse genotype (WT=willd type, STAT3_KO=STAT3 cardiac-restricted KO). This microarray analysis includes 3 mice per group.
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| Contributor(s) |
Pedretti S, Brulhart-Meynet M, Montecucco F, Lecour S, James RW, Frias MA |
| Citation(s) |
31220137 |
| |
| Submission date |
Dec 20, 2018 |
| Last update date |
Jun 25, 2019 |
| Contact name |
Celine Delucinge |
| Organization name |
University of Geneva
|
| Department |
iGE3 Genomics Platform
|
| Street address |
1 rue Michel Servet
|
| City |
Geneva |
| ZIP/Postal code |
1211 |
| Country |
Switzerland |
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| Platforms (1) |
| GPL19117 |
[miRNA-4] Affymetrix Multispecies miRNA-4 Array |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA510950 |
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