|
| Status |
Public on Sep 14, 2009 |
| Title |
Whole blood transcript profiling of rheumatoid arthritis patients |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
The whole blood was collected pre-treatment from rheumatoid arthritis patients starting the anti_TNF therapy. All patients were naïve to anti_TNFs. The disease activity was measured using the DAS28 score at the pre-treatment visit1 (DAS28_v1) and 14 weeks after treatment visit3 (DAS28_v3). The response to the therapy was evaluated using the EULAR [European League Against Rheumatism] definition of the response. The objective of the data analysis was to identify gene expression coorelating with response as well as to identify genes that differentiate responders versus non-responders pre-treatment. The results of this investigation identified 8 trainscripts that predict responders vs. non-responders with 89% accuracy.
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| |
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| Overall design |
Patients' response to anti-TNF was assessed using EULAR score and patients were classified as responders, moderate responders and non-responders. Genes correlating with the response status have been identified.
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| |
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| Contributor(s) |
Bienkowska J, Gregersen PK, Batlivwalla F, Carulli J |
| Citation(s) |
19699293 |
| |
| Submission date |
Mar 17, 2009 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Jadwiga Bienkowska |
| E-mail(s) |
jbienkowska@gmail.com
|
| Phone |
6174602469
|
| Organization name |
BiogenIdec
|
| Street address |
45 Fayette Str Apt 3
|
| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02139 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
| Samples (86)
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| Relations |
| BioProject |
PRJNA116555 |
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