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| Status |
Public on Sep 20, 2011 |
| Title |
BT474 and BT474-J4 microarray data |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
These data provide scientific information to understand the mechanism of action of lapatinib resistance in HER2-positive patients and to test the combination of HER2-targeted agents and GSK1363089 (foretinib) in the clinic by using an acquired lapatinib-resistant cell line.
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| |
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| Overall design |
Cell lines (BT474, an HER2-positive and lapatinib-sensitive cell line; BT474-J4, an acquired lapatinib-resistant cell line) were treated with lapatinib alone (1uM), foretinib (GSK1363089) alone (0.1 uM), a combination of lapatinib (1 uM) and foretinib (0.1 uM), or DMSO control for 24 hours. Triplicates were performed.
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| |
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| Contributor(s) |
Liu Y, Liu L, Gilmer T, Martin A |
| Citation(s) |
19671800 |
| |
| Submission date |
May 20, 2009 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Yuan Liu |
| Fax |
610-917-5000
|
| Organization name |
GlaxoSmithKline
|
| Department |
Biomarker
|
| Street address |
1250 South Collegeville Rd
|
| City |
Collegeville |
| State/province |
PA |
| ZIP/Postal code |
19446 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
| Samples (18)
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| Relations |
| BioProject |
PRJNA115069 |
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