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| Status |
Public on Feb 23, 2022 |
| Title |
mRNA expression analysis of the hippocampus in a vervet monkey model of fetal alcohol spectrum disorder |
| Platform organism |
Macaca mulatta |
| Sample organism |
Chlorocebus aethiops |
| Experiment type |
Expression profiling by array
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| Summary |
Alcohol preferring vervet dams were permitted to ingest alcohol 4 days/week during the second half of gestation (e90-e165) and paired with sucrose matched controls. Cases and controls were sacrificed with subsequent hippocampal extraction at 5 months and 2 years. RNA was extracted according to the manufacturer's protocol and hybridized to the Affymetrix Rhesus Genechip microarray.
We sought to identify pathways and genes involved in the development of fetal alcohol spectrum disorder in a non-human primate in order to develop an understanding of how this disorder may develop in humans.
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| Overall design |
2x2 ANOVA, main effect=alcohol, main effect=age, main effect=interaction. Six replicates/group
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| Contributor(s) |
Gillis RF, Palmour R |
| Citation(s) |
35305552, 37371413 |
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| Submission date |
Apr 28, 2021 |
| Last update date |
Sep 11, 2023 |
| Contact name |
Roberta M Palmour |
| E-mail(s) |
roberta.palmour@mcgill.ca
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| Phone |
5143987303
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| Organization name |
McGill
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| Department |
Psychiatry
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| Street address |
1033 Pine West
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| City |
Montreal |
| State/province |
Quebec |
| ZIP/Postal code |
H3A1A3 |
| Country |
Canada |
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| Platforms (1) |
| GPL3535 |
[Rhesus] Affymetrix Rhesus Macaque Genome Array |
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| Samples (24)
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| GSM5269090 |
Control 2 years, replicate 4 |
| GSM5269091 |
Control 2 years, replicate 5 |
| GSM5269092 |
Control 2 years, replicate 6 |
| GSM5269093 |
Control 5 months, replicate 1 |
| GSM5269094 |
Control 5 months, replicate 2 |
| GSM5269095 |
Control 5 months, replicate 3 |
| GSM5269096 |
Control 5 months, replicate 4 |
| GSM5269097 |
Control 5 months, replicate 5 |
| GSM5269098 |
Control 5 months, replicate 6 |
| GSM5269099 |
Fetal alcohol exposed, 2 years replicate 1 |
| GSM5269100 |
Fetal alcohol exposed, 2 years replicate 2 |
| GSM5269101 |
Fetal alcohol exposed, 2 years replicate 3 |
| GSM5269102 |
Fetal alcohol exposed, 2 years replicate 4 |
| GSM5269103 |
Fetal alcohol exposed, 2 years replicate 6 |
| GSM5269104 |
Fetal alcohol exposed, 5 months replicate 2 |
| GSM5269105 |
Fetal alcohol exposed, 5 months replicate 3 |
| GSM5269106 |
Fetal alcohol exposed, 5 months replicate 4 |
| GSM5269107 |
Fetal alcohol exposed, 5 months replicate 5 |
| GSM5269108 |
Fetal alcohol exposed, 5 months replicate 6 |
| GSM5269109 |
Fetal alcohol exposed, 2 years replicate 5, discarded array |
| GSM5269110 |
Fetal alcohol exposed, 5 months replicate 2, discarded array |
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| Relations |
| BioProject |
PRJNA725871 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE173516_RAW.tar |
114.1 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data provided as supplementary file |
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