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| Status |
Public on May 02, 2024 |
| Title |
Expression data from Saccharomyces cerevisiae |
| Organism |
Saccharomyces cerevisiae |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Reprogramming a non-methylotrophic industrial host, such as Saccharomyces cerevisiae, to a synthetic methylotroph reprents a huge challenge due to the complex regulation in yeast. Through TMC strategy together with ALE strategy, we completed a strict synthetic methylotrophic yeast that could use methanol as the sole carbon source. However, how cells respond to methanol and remodel cellular metabolic network on methanol were not clear. Therefore, genome-scale transcriptional analysis was performed to unravel the cellular reprograming mechanisms underlying the improved growth phenotype.
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| Overall design |
To understand how cells reprogram cellular metabolism to adapt growth on methanol,the evolved strain CX01F (B1-3) was compared with its parental strain CX01 (Sample1-3).
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| Contributor(s) |
Zhan C, Li X, Keasling J, Chen Y, Nielsen J |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
May 04, 2021 |
| Last update date |
May 02, 2024 |
| Contact name |
chunjun zhan |
| E-mail(s) |
chunjunzhan@lbl.gov
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| Phone |
5715233586
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| Organization name |
JEBI
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| Street address |
2131 NAPA St
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| City |
Richmond |
| State/province |
CA |
| ZIP/Postal code |
94804 |
| Country |
USA |
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| Platforms (1) |
| GPL21656 |
Illumina HiSeq 4000 (Saccharomyces cerevisiae) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA727086 |
| SRA |
SRP318378 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE173802_Processed_data_RNAseq.csv.gz |
113.7 Kb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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