|
| Status |
Public on May 01, 2010 |
| Title |
Analysis of testicular transcriptome changes in the presence of Y-chromosomal microdeletions |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
We investigated the transcriptional changes in human testis in the presence of AZFc/AZFb+c microdeletions. As one encounters a dominating 'germ cell effect' in this pursuit, testicular biopsies were pre-selected by clustering based on similar quantitative germ cell composition.
Statistical testing was employed to filter genes that are influenced by the 'deletion effect' using the selected subset of biopsies, thereby obtaining several hundered genes that may be involved in YCMD-induced spermatogenic impairment.
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| |
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| Overall design |
A set of 34 biopsies was used from which 26 samples remained after pre-selection. Transcriptional changes of the control and YCMD groups were analyzed for hypospermatogenesis, meiotic arrest and Sertoli-cell only syndrome
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| |
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| Contributor(s) |
Cappallo-Obermann H, von Kopylow K, Schulze W, Spiess A |
| Citation(s) |
20668881 |
| |
| Submission date |
Apr 30, 2010 |
| Last update date |
Sep 27, 2013 |
| Contact name |
Andrej-Nikolai Spiess |
| E-mail(s) |
a.spiess@uke.uni-hamburg.de
|
| Phone |
+49-40-42803-1585
|
| Fax |
+49-40-42803-1554
|
| URL |
http://www.dr-spiess.de
|
| Organization name |
University Hospital Hamburg-Eppendorf
|
| Department |
Andrology
|
| Lab |
Molecular Andrology
|
| Street address |
Martinistr. 52
|
| City |
20246 Hamburg |
| State/province |
n/a |
| ZIP/Postal code |
n/a |
| Country |
Germany |
| |
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| Platforms (1) |
| GPL2891 |
GE Healthcare/Amersham Biosciences CodeLink™ UniSet Human 20K I Bioarray |
|
| Samples (34)
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| Relations |
| BioProject |
PRJNA126989 |
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