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| Status |
Public on Dec 31, 2010 |
| Title |
Mature dendritic cells under hypoxic condition |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Dendritic cells (DCs) are professional antigen-presenting cells whose activity is intrinsically linked to the microenvironment. Hypoxia is a condition of low oxygen tension occurring in inflammatory tissues that creates a special microenvironment conditioning cell physiology. We studied the effects of hypoxia on the differentiation of human monocytes into DCs and maturation into mature DCs. Mature DCs were differentiated in vitro from human monocytes under normoxic or hypoxic conditions and the gene expression profile was determined.
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| Overall design |
The expression profile of mature dendritic cells under normoxia vs hypoxia was studied. Three healthy donors were used as biologial replicates.
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| Contributor(s) |
Bosco MC, Pierobon D, Blengio F, Raggi F, Vanni C, Cappello P, Gattorno M, Novelli F, Giovarelli M, Varesio L |
| Citation(s) |
21148811 |
| |
| Submission date |
Jun 10, 2010 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Paolo Fardin |
| E-mail(s) |
paolofardin@ospedale-gaslini.ge.it
|
| Organization name |
Istiuto Giannina Gaslini
|
| Department |
Molecular Biology
|
| Street address |
Largo G. Gaslini 5
|
| City |
Genoa |
| ZIP/Postal code |
16147 |
| Country |
Italy |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA128713 |
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