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Series GSE224352 Query DataSets for GSE224352
Status Public on Apr 21, 2023
Title Longitudinal study of DNA methylation changes during mouse pregnancy
Platform organisms Homo sapiens; Mus musculus; Rattus norvegicus
Sample organism Mus musculus
Experiment type Methylation profiling by array
Summary Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation and loss of function, leading to increases in morbidity and mortality. However, recent in vitro studies have raised the possibility of age reversal. We characterized several models in which biological age, assessed primarily through analysis of DNA methylation, undergoes reversible changes. Pregnancy is one such example.
 
Overall design We studied a mouse model of pregnancy. Following a baseline blood sample, C57Bl/6 mice were mated, and two blood samples were taken during the early and late phases of their pregnancies. Following parturition and a period of recovery, a final blood sample was collected. We subjected DNA isolated from these blood samples to the HorvathMammalMethylChip40 for methylation profiling.
 
Contributor(s) Poganik JR, Zhang B, Baht GS, Tyshkovskiy A, Deik A, Kerepesi C, Yim SH, Lu AT, Haghani A, Gong T, Hedman AM, Andolf E, Pershagen G, Almqvist C, Clish CB, Horvath S, White JP, Gladyshev VN
Citation(s) 37086720
Submission date Feb 02, 2023
Last update date Jun 20, 2023
Contact name Jesse Poganik
Organization name Brigham and Women's Hospital, Harvard Medical School
Department Medicine/Genetics
Street address 77 Avenue Louis Pasteur
City Boston
State/province MA
ZIP/Postal code 02115
Country USA
 
Platforms (1)
GPL28271 Illumina HorvathMammalianMethylChip40 BeadChip
Samples (46)
GSM7020288 genomic DNA from Blood from mouse 280626B at time point 1
GSM7020289 genomic DNA from Blood from mouse 280626N at time point 1
GSM7020290 genomic DNA from Blood from mouse 280623B at time point 1
Relations
BioProject PRJNA930708

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE224352_GEO_DetPvals.csv.gz 4.0 Mb (ftp)(http) CSV
GSE224352_GEO_normazliedData.csv.gz 13.7 Mb (ftp)(http) CSV
GSE224352_RAW.tar 34.4 Mb (http)(custom) TAR (of IDAT)
Processed data included within Sample table
Processed data are available on Series record
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