|
| Status |
Public on Feb 09, 2011 |
| Title |
Gene expression profiles of mouse Blimp1 +/gfp and Blimp1 gfp/gfp regulatory T cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Regulatory T (Treg) cells are required for peripheral tolerance. Recent evidence indicates that Treg cells can adopt specialized differentiation programs in the periphery that are controlled by transcription factors usually associated with T helper differentiation. We demonstrate that expression of the transcription factor Blimp1 defines a population of Treg cells that localize predominantly to mucosal sites and produces IL-10. Blimp1 is required for IL-10 production by these cells and for their tissue homeostasis. A list of differentially expressed genes were identified from this whole-genome expression profiling experiment.
|
| |
|
| Overall design |
Mouse Blimp1 +/gfp and Blimp1 gfp/gfp regulatory T cells were analyzed. Three replicates each.
|
| |
|
| Contributor(s) |
Shi W, Smyth GK, Nutt SL, Kallies A |
| Citation(s) |
21378976 |
| |
| Submission date |
Feb 08, 2011 |
| Last update date |
Jan 18, 2013 |
| Contact name |
Wei Shi |
| E-mail(s) |
Wei.Shi2@monash.edu
|
| Organization name |
Monash University
|
| Street address |
Wellington Rd
|
| City |
Clayton |
| State/province |
Victoria |
| ZIP/Postal code |
3800 |
| Country |
Australia |
| |
|
| Platforms (1) |
| GPL6105 |
Illumina mouse-6 v1.1 expression beadchip |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA137577 |
Less...
More...