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| Status |
Public on Sep 22, 2005 |
| Title |
Transcriptional profiling of HHV-6 infeceted T cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The immune response to viral infection represents complex network of dynamic gene and protein interactions. We present here the dynamic gene network of host immune response during human herpesvirus type 6 (HHV-6) infection in a adult T cell leukemia (ATL) cell line. Using a pathway-focused oligonucleotide DNA microarray, we found a possible association between chemokines genes regulating Th1/Th2 balance and genes regulating T-cell proliferation during HHV-6B infection.
Keywords: Time course experiment
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| Overall design |
This study aimed to determine genes regulating immune response during viral infection using an in vitro model system. We utilized a CD4+ T cell line which shows an efficient propagation of HHV-6B, as a model of acute infection of HHV-6B as well as that of persistent infection We explored a pathway-focused oligonucleotide DNA microarray that contains genes closely related with inflammatory responses.
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| Contributor(s) |
Takaku T, Ohyashiki JH, Ohyashiki K |
| Citation(s) |
16140273 |
| |
| Submission date |
Jul 15, 2005 |
| Last update date |
Mar 16, 2012 |
| Contact name |
Tomoiku Takaku |
| E-mail(s) |
t-tom@venus.dti.ne.jp
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| Organization name |
Tokyo Medical University
|
| Department |
First Department of internal Medicine
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| Street address |
6-7-1, Nishishinjuku, Shinjuku
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| City |
Tokyo |
| ZIP/Postal code |
160-0023 |
| Country |
Japan |
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| Platforms (1) |
| GPL2531 |
Novusgene type 3 Hematology/Oncology TMU 667 array |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA92445 |
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