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| Status |
Public on Nov 06, 2012 |
| Title |
The yeast PP2A-CDC55 phosphatase regulates the transcriptional response to hyperosmolarity stress by regulating Msn2 and Msn4 [Time course 2] |
| Platform organism |
Saccharomyces cerevisiae |
| Sample organism |
Saccharomyces cerevisiae W303 |
| Experiment type |
Expression profiling by array
|
| Summary |
The yeast PP2A-Cdc55 Serine/Threonine phosphatase regulates transcription under certain conditions. It is required for full activation of the environmental stress response mediated by the transcription factors Msn2 and Msn4. PP2A-Cdc55 contributes to sustained nuclear accumulation of Msn2 and Msn4 and extended chromatin recruitment under stress conditions such as hyperosmolarity stress. Transcript profiles of Msn2 and Msn4 double mutants are similar to cdc55 and the corresponding triple mutants. This argues for a Msn2/4 specific function of PP2A-Cdc55.
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| Overall design |
Time course of 0, 10 20 and 30 minutes hyperosmolarity treated yeast cells of msn2msn4 or msn2msn4cdc55 genetic background, both carrying plasmid pMsn2pMsn2DNES; reference hybridization: untreated W303 msn2msn4 pMsn2pMsn2DNES labelled with Cy3
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| Contributor(s) |
Schüller C, Petryshyn A, Klopf E |
| Citation(s) |
23275436 |
| |
| Submission date |
Nov 05, 2012 |
| Last update date |
May 18, 2017 |
| Contact name |
Christoph Schueller |
| E-mail(s) |
Christoph.schueller@boku.ac.at
|
| Organization name |
University of Natural Resources and Life Sciences, Vienna (BOKU)
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| Department |
Department of Applied Genetics and Cell Biology
|
| Lab |
Schuller
|
| Street address |
Konrad Lorenz Strasse 24
|
| City |
Tulln |
| ZIP/Postal code |
3430 |
| Country |
Austria |
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| Platforms (1) |
| GPL16244 |
Agilent-016322 Yeast (V2) Gene Expression 8x15K Microarray (Probe Name version) |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE42034 |
The yeast PP2A-CDC55 phosphatase regulates the transcriptional response to hyperosmolarity stress by regulating Msn2 and Msn4 |
|
| Relations |
| BioProject |
PRJNA178956 |
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