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Status |
Public on Feb 23, 2014 |
Title |
Targeting Csnk1a1 induces selective p53-dependant killing of leukemia stem cells |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
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Summary |
We found found that casein kinase 1 alpha (Csnk1a1), a serine threonine kinase and negative regulator of beta catenin, is essential for leukemia cells in vivo.
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Overall design |
We examined the effect of Csnk1a1 knowckdown by gene expression profiling in primary leukemia cells.
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Contributor(s) |
Järås M, Miller PG, Chu LP, Schneider RK, Puram RV, Al-Shahrour F, Breyfogle J, Fink E, Hartwell KA, McConkey ME, Cowley GS, Root DE, Kharas MG, Mullally A, Ebert BL |
Citation(s) |
24616378 |
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Submission date |
Dec 03, 2013 |
Last update date |
Jan 16, 2019 |
Contact name |
Fatima Al-Shahrour |
E-mail(s) |
shahrour@broadinstitute.org
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Organization name |
Broad Institute of MIT and Harvard
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Department |
Cancer program
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Street address |
7 Cambridge Center
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City |
Cambridge |
State/province |
MA |
ZIP/Postal code |
02142 |
Country |
USA |
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Platforms (1) |
GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
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Samples (9)
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GSM1278262 |
Csnk1a1 knockdown (Csnk1a1-94 shRNA) in LSCs rep1 |
GSM1278263 |
Csnk1a1 knockdown (Csnk1a1-94 shRNA) in LSCs rep2 |
GSM1278264 |
Csnk1a1 knockdown (Csnk1a1-94 shRNA) in LSCs rep3 |
GSM1278265 |
Csnk1a1 knockdown (Csnk1a1-97 shRNA) in LSCs rep4 |
GSM1278266 |
Csnk1a1 knockdown (Csnk1a1-97 shRNA) in LSCs rep5 |
GSM1278267 |
Csnk1a1 knockdown (Csnk1a1-97 shRNA) in LSCs rep6 |
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Relations |
BioProject |
PRJNA230476 |