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| Status |
Public on May 20, 2015 |
| Title |
Sox4 links tumor suppression to accelerated aging in mice [Telogen] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Sox4 is a transcription factor expressed during embryonic development and some adult tissues such as lymphoid organs, pancreas, intestine and skin. During embryogenesis, Sox4 regulates the survival of mesenchymal and neural progenitors, lymphocyte and myeloid differentiation, and pancreatic, bone and cardiac development. Aberrantly increased Sox4 expression is linked to malignant transformation and metastasis in several types of human cancer. To study the role of Sox4 in the adult organism, we first generated mice with reduced whole-body Sox4 expression. These mice display a plethora of age-related degenerative disorders and reduced spontaneous cancer incidence, indicating a role for this protein in maintaining adult tissue homeostasis and in tumor growth. To specifically address a role for Sox4 in adult stem cells, we conditionally deleted Sox4 (Sox4cKO) in stratified epithelia. Sox4cKO mice show increased skin stem cell quiescence and DNA damage accumulation, accompanied by resistance to chemical carcinogenesis. These phenotypes correlate with downregulation of cell cycle, DNA repair and skin stem cell genes in the absence of Sox4. Altogether, these findings highlight the importance of Sox4 in adult tissue homeostasis and cancer.
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| Overall design |
Sox4 WT and cKO (conditional KO in skin) skin was collected for microarray hybridization, to study the contribution of Sox4 to skin homeostasis in basal conditions (Telogen)
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| Contributor(s) |
Foronda M, Martínez P, Schoeftner S, Gómez-López G, Schneider R, Flores JM, Pisano DG, Blasco MA |
| Citation(s) |
25043184, 26697322 |
| |
| Submission date |
Jun 02, 2014 |
| Last update date |
Mar 30, 2020 |
| Contact name |
Miguel Foronda |
| E-mail(s) |
mforonda@staffmail.ed.ac.uk
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| Organization name |
CNIO
|
| Street address |
Calle Melchor Fernández Almagro
|
| City |
Madrid |
| State/province |
Select a State or Province |
| ZIP/Postal code |
28029 |
| Country |
Spain |
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| Platforms (1) |
| GPL10787 |
Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Probe Name version) |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE58155 |
Sox4 links tumor suppression to accelerated aging in mice |
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| Relations |
| BioProject |
PRJNA251400 |
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