GEO Accession viewer

NCBI > GEO > Accession Display

Not logged in | Login

GEO help: Mouse over screen elements for information.

Series GSE5843

Query DataSets for GSE5843

Status

Public on May 01, 2007

Title

Expression profiling defines a recurrence signature in lung adenocarcinoma

Organism

Homo sapiens

Experiment type

Expression profiling by array

Summary

Lung cancer remains the leading cause of cancer death worldwide. Overall 5-year survival is about 10-15% and despite curative intent surgery, treatment failure is primarily due to recurrent disease. Conventional prognostic markers are unable to determine which patients with completely resected disease within each stage group are likely to relapse. To identify a gene signature associated with recurrent adenocarcinoma (AC) of lung, we analyzed primary tumour gene expression for a total of 48 stage I ACs on 22,323 element microarrays, comparing expression profiles for individuals who remained disease-free for a minimum of 36 months with those from individuals whose disease recurred within 18 months of complete resection. Genome-wide profiling has revealed a distinct gene expression profile for recurrent lung AC which may be clinically useful as a prognostic tool.
Keywords: non-small cell lung carcinoma, squamous cell, tumor recurrence, expression profiling

Overall design

Expression profiling using 22K element microarrays of 48 adenocarcinomas.

Contributor(s)

Larsen JE, Pavey SJ, Clarke BE, Bowman RV, Hayward NK, Fong KM

Citation(s)

17504995

Submission date

Sep 14, 2006

Last update date

Apr 07, 2015

Contact name

Jill Everland Larsen

E-mail(s)

j.larsen@uq.edu.au

Phone

+61731394110

Fax

+61731394957

Organization name

The Prince Charles Hospital

Department

Thoracic Medicine

Lab

Thoracic Research Lab

Street address

Rode Road, Chermside

City

Brisbane

State/province

Queensland

ZIP/Postal code

4032

Country

Australia

Platforms (1)

GPL3877

PRHU05-S1-0006 (PC Human Operon v2 21k)

Samples (48)

More...

GSM135983	Primary Lung Adenocarcinoma Sample_A1
GSM135984	Primary Lung Adenocarcinoma Sample_A2
GSM135985	Primary Lung Adenocarcinoma Sample_A3

GSM135986	Primary Lung Adenocarcinoma Sample_A4
GSM135987	Primary Lung Adenocarcinoma Sample_A5
GSM135988	Primary Lung Adenocarcinoma Sample_A6
GSM135990	Primary Lung Adenocarcinoma Sample_A8
GSM135991	Primary Lung Adenocarcinoma Sample_A9
GSM135992	Primary Lung Adenocarcinoma Sample_A10
GSM135993	Primary Lung Adenocarcinoma Sample_A11
GSM135994	Primary Lung Adenocarcinoma Sample_A12
GSM135995	Primary Lung Adenocarcinoma Sample_A13
GSM135996	Primary Lung Adenocarcinoma Sample_A14
GSM135997	Primary Lung Adenocarcinoma Sample_A15
GSM135998	Primary Lung Adenocarcinoma Sample_A16
GSM135999	Primary Lung Adenocarcinoma Sample_A17
GSM136000	Primary Lung Adenocarcinoma Sample_A18
GSM136001	Primary Lung Adenocarcinoma Sample_A19
GSM136002	Primary Lung Adenocarcinoma Sample_A20
GSM136003	Primary Lung Adenocarcinoma Sample_A21
GSM136004	Primary Lung Adenocarcinoma Sample_A22
GSM136005	Primary Lung Adenocarcinoma Sample_A23
GSM136006	Primary Lung Adenocarcinoma Sample_A24
GSM136007	Primary Lung Adenocarcinoma Sample_A25
GSM136008	Primary Lung Adenocarcinoma Sample_A26
GSM136009	Primary Lung Adenocarcinoma Sample_A27
GSM136010	Primary Lung Adenocarcinoma Sample_A28
GSM136011	Primary Lung Adenocarcinoma Sample_A29
GSM136012	Primary Lung Adenocarcinoma Sample_A30
GSM136013	Primary Lung Adenocarcinoma Sample_A31
GSM136014	Primary Lung Adenocarcinoma Sample_A32
GSM136015	Primary Lung Adenocarcinoma Sample_A33
GSM136016	Primary Lung Adenocarcinoma Sample_A34
GSM136017	Primary Lung Adenocarcinoma Sample_A35
GSM136018	Primary Lung Adenocarcinoma Sample_A36
GSM136019	Primary Lung Adenocarcinoma Sample_A37
GSM136020	Primary Lung Adenocarcinoma Sample_A38
GSM136021	Primary Lung Adenocarcinoma Sample_A39
GSM136022	Primary Lung Adenocarcinoma Sample_A40
GSM136023	Primary Lung Adenocarcinoma Sample_A41
GSM136024	Primary Lung Adenocarcinoma Sample_A42
GSM136025	Primary Lung Adenocarcinoma Sample_A43
GSM136026	Primary Lung Adenocarcinoma Sample_A44
GSM136027	Primary Lung Adenocarcinoma Sample_A45
GSM136028	Primary Lung Adenocarcinoma Sample_A46
GSM136029	Primary Lung Adenocarcinoma Sample_A47
GSM136030	Primary Lung Adenocarcinoma Sample_A48
GSM136031	Primary Lung Adenocarcinoma Sample_A49

Relations

Affiliated with

GSE67639

BioProject

PRJNA97243

Clinical data header descriptions
Sample ID
Histology
Sex
Age
Pack-year
Differentiation
Stage
Survival time (months)
Survival status

Data table
Sample ID	Histology	Sex	Age	Pack-year	Differentiation	Stage	Survival time (months)	Survival status
Sample_A1	Adenocarcinoma	F	57	15	M	IB	124.81	A
Sample_A10	Adenocarcinoma	M	71	37	P	IA	69.22	A
Sample_A11	Adenocarcinoma	M	60	30	W	IA	113.68	A
Sample_A12	Adenocarcinoma	M	60	99	P	IA	92.52	A
Sample_A13	Adenocarcinoma	M	77	92	M	IB	70.44	A
Sample_A14	Adenocarcinoma	M	58	118	P	IA	70.57	A
Sample_A15	Adenocarcinoma	F	54	45	P	IB	69.82	A
Sample_A16	Adenocarcinoma	F	55	47	P	IA	66.56	A
Sample_A17	Adenocarcinoma	M	67	77	M	IA	67.25	A
Sample_A18	Adenocarcinoma	M	62	23	P	IA	70.51	A
Sample_A19	Adenocarcinoma	M	74	44	P	IB	57.89	A
Sample_A2	Adenocarcinoma	F	43	28	W	IA	124.12	D
Sample_A20	Adenocarcinoma	F	78	43	M	IB	56.11	D
Sample_A21	Adenocarcinoma	M	71	10	P	IA	54.47	A
Sample_A22	Adenocarcinoma	M	73	40	W	IB	53.06	A
Sample_A23	Adenocarcinoma	M	69	27	P	IB	50.79	A
Sample_A24	Adenocarcinoma	M	66	36	W	IA	53.4	A
Sample_A25	Adenocarcinoma	F	77	.	M	IB	46.03	A
Sample_A26	Adenocarcinoma	M	68	76	W	IB	44.39	A
Sample_A27	Adenocarcinoma	M	59	51	W	IB	164.04	A

Total number of rows: 48

Table truncated, full table size 4 Kbytes.

Download family	Format
SOFT formatted family file(s)	SOFT
MINiML formatted family file(s)	MINiML
Series Matrix File(s)	TXT

Supplementary data files not provided