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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Dec 30, 2015 |
| Title |
The ETS transcription factor Elf5 drives lung metastasis in luminal breast cancer via recruitment of Gr-1+CD11b+ myeloid derived suppressor cells [chronic] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Elf5 expression in mammary progenitor cells regulates a cell fate decision that establishes the alveolar cell lineage. In luminal breast cancer cells, increased Elf5 expression suppressed estrogen receptor and FoxA1 expression and was implicated in the acquisition of resistance to the cytostatic effects of antiestrogen therapy. We show that in the PyMT model of luminal breast cancer, increased Elf5 expression drives lung metastasis by recruiting myeloid-‐derived suppressor cells, and that this activity overcomes the epithelializing influence of Elf5. Breast cancer expression signatures identify a similar process in humans, and increased Elf5 immunohistochemical staining predicts poor prognosis in the luminal A subgroup. Thus Elf5 may promote escape from hormonal therapy and drive metastasis in luminal breast cancer.
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| Overall design |
Gene expression analysis of wild-type PyMT mammary tumors, mammary tumors from chronic (8 weeks) Elf5 dox induced expression (EGFP+ sorted) with control comparison (EGFP- sorted), and Elf5/EGFP+ lung metastasis
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| Contributor(s) |
GallegoOrtega D, Ledger A, Roden DL, Cho C, Allerdice SL, Lee HJ, Valdes-Mora F, Young AI, Lee BY, Kaplan W, Salomon R, Piggin C, Rabinovich B, Millar E, Oakes SR, Chtanova T, Swarbrick A, Naylor M, O'Toole S, Gee JM, Ellis I, Clark SJ, Ormandy CJ |
| Citation(s) |
26717410 |
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| Submission date |
Jun 23, 2014 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Daniel Roden |
| E-mail(s) |
d.roden@garvan.org.au
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| Organization name |
Garvan Institute
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| Street address |
384 Victoria Street
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| City |
Sydney |
| State/province |
NSW |
| ZIP/Postal code |
2010 |
| Country |
Australia |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (12)
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| GSM1418747 |
mammary_gland_tumor-Elf5_EGFP_neg rep1 |
| GSM1418748 |
mammary_gland_tumor-Elf5_EGFP_neg rep2 |
| GSM1418749 |
mammary_gland_tumor-Elf5_EGFP_neg rep3 |
| GSM1418750 |
mammary_gland_tumor-Elf5_EGFP_pos rep1 |
| GSM1418751 |
mammary_gland_tumor-Elf5_EGFP_pos rep2 |
| GSM1418752 |
mammary_gland_tumor-Elf5_EGFP_pos rep3 |
| GSM1418753 |
mammary_gland_tumor-Elf5_Metastasis rep1 |
| GSM1418754 |
mammary_gland_tumor-Elf5_Metastasis rep2 |
| GSM1418755 |
mammary_gland_tumor-Elf5_Metastasis rep3 |
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| This SubSeries is part of SuperSeries: |
| GSE58729 |
The ETS transcription factor Elf5 drives lung metastasis in luminal breast cancer via recruitment of Gr-1+CD11b+ myeloid derived suppressor cells |
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| Relations |
| BioProject |
PRJNA253293 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE58728_RAW.tar |
48.2 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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