 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Nov 02, 2015 |
| Title |
Targeted mRNA gene expression profiling of primary tumors and lung metastases using a mouse model of spontaneous metastatic mammary carcinoma |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
In this study, we explored the molecular basis of site-specific metastasis of breast cancer to the lungs in a clinically relevant model based on the JygMC(A) cell line. In this dataset, we include expression data from JygMC(A) primary mammary tumors (carcinoma and EMT-like areas), lung metastases, normal mammary glands and normal lung parenchyma.
|
| |
|
| Overall design |
In total, 36 laser microdissected samples were analyzed. We built a customized NanoString nCounter® Gene Expression Codeset of 104 genes and controls that contained significant embryonic core stem cell genes and EMT-MET markers. This customized assay was performed to target gene expression profiling on the following samples: primary tumor carcinoma, primary tumor EMT, lung metastasis, normal mammary gland and normal lung parenchyma.
|
| |
|
| Contributor(s) |
Pereira de Castro N, Salomon D, Merchant A, Abrams N |
| Citation(s) |
27077656, 26059540 |
| |
| Submission date |
Dec 08, 2014 |
| Last update date |
Oct 10, 2019 |
| Contact name |
David Salomon |
| E-mail(s) |
salomond@mail.nih.gov
|
| Organization name |
NIH
|
| Department |
NCI
|
| Street address |
1050 Boyles Drive, Bldg. 560 Room 1246
|
| City |
Frederick |
| State/province |
MD |
| ZIP/Postal code |
21701 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL19518 |
Custom nCounter Gene Expression CodeSets (Catalog No. GXA-P1CS-048, Nanostring Technologies, Inc., Seattle, WA) |
|
| Samples (36)
|
| GSM1561133 |
mammary tumors carcinoma, biological rep2 |
| GSM1561134 |
mammary tumors carcinoma, biological rep3 |
| GSM1561135 |
mammary tumors carcinoma, biological rep4 |
| GSM1561136 |
mammary tumors carcinoma, biological rep5 |
| GSM1561137 |
mammary tumors carcinoma, biological rep6 |
| GSM1561138 |
mammary tumors carcinoma, biological rep7 |
| GSM1561139 |
mammary tumors carcinoma, biological rep8 |
| GSM1561140 |
mammary tumors EMT, biological rep1 |
| GSM1561141 |
mammary tumors EMT, biological rep2 |
| GSM1561142 |
mammary tumors EMT, biological rep3 |
| GSM1561143 |
mammary tumors EMT, biological rep4 |
| GSM1561144 |
mammary tumors EMT, biological rep5 |
| GSM1561145 |
mammary tumors EMT, biological rep6 |
| GSM1561146 |
mammary tumors EMT, biological rep7 |
| GSM1561147 |
mammary tumors EMT, biological rep8 |
| GSM1561148 |
mammary tumors EMT, biological rep9 |
| GSM1561149 |
mammary tumors EMT, biological rep10 |
| GSM1561150 |
mammary tumors EMT, biological rep11 |
| GSM1561151 |
mammary tumors metastasis to lungs, biological rep1 |
| GSM1561152 |
mammary tumors metastasis to lungs, biological rep2 |
| GSM1561153 |
mammary tumors metastasis to lungs, biological rep3 |
| GSM1561154 |
mammary tumors metastasis to lungs, biological rep4 |
| GSM1561155 |
mammary tumors metastasis to lungs, biological rep5 |
| GSM1561156 |
mammary tumors metastasis to lungs, biological rep6 |
| GSM1561157 |
mammary tumors metastasis to lungs, biological rep7 |
| GSM1561158 |
mammary tumors metastasis to lungs, biological rep8 |
| GSM1561159 |
mammary tumors metastasis to lungs, biological rep9 |
| GSM1561160 |
normal lung parenchyma, biological rep1 |
| GSM1561161 |
normal lung parenchyma, biological rep2 |
| GSM1561162 |
normal lung parenchyma, biological rep3 |
| GSM1561163 |
normal mammary gland, biological rep1 |
| GSM1561164 |
normal mammary gland, biological rep2 |
| GSM1561165 |
normal mammary gland, biological rep3 |
|
| Relations |
| BioProject |
PRJNA269618 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE63951_RAW.tar |
110.0 Kb |
(http)(custom) |
TAR (of RCC) |
| Processed data included within Sample table |
|
|
|
|
 |
Less...
More...