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| Status |
Public on May 25, 2015 |
| Title |
VEPH1 expression in ovarian cancer cell lines and its relationship to TGF-B signaling |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
The current study examines the functional role of VEPH1, a PH domain containing protein and the human ortholog of Drosophila melted, in ovarian cancer cell lines. Elevated VEPH1 is associated with FOXO and Hippo signaling and was found to suppress TGF-ß induced target genes.
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| Overall design |
SKOV3 cell lines were established as either CdCl2 inducible Flag-tagged VEPH1 expression or mock-transfected. Gene expression profiles were then generated both with and without the presence of TGF-ß to induce TGF-ß signaling. 3 replicates per treatment group were used.
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| Contributor(s) |
Shathasivam P, Kollara A, Ringuette M, Virtanen C, Wrana J, Brown T |
| Citation(s) |
26039994 |
| |
| Submission date |
Apr 10, 2015 |
| Last update date |
Aug 13, 2018 |
| Contact name |
carl virtanen |
| E-mail(s) |
cvirtane@uhnresearch.ca
|
| Organization name |
University Health Network
|
| Department |
Princess Margaret Genomics Centre
|
| Street address |
101 College St
|
| City |
Toronto |
| State/province |
Ontario |
| ZIP/Postal code |
M5G 1L7 |
| Country |
Canada |
| |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (12)
|
| GSM1655461 |
Mock vector expressing SKOV3 cells treated with TGF-ß rep2 |
| GSM1655462 |
VEPH1 expressing SKOV3 cells treated with TGF-ß rep3 |
| GSM1655463 |
Mock vector expressing SKOV3 cells treated with TGF-ß rep1 |
| GSM1655464 |
VEPH1 expressing SKOV3 cells treated with TGF-ß rep2 |
| GSM1655465 |
VEPH1 expressing SKOV3 cells treated with TGF-ß rep1 |
| GSM1655466 |
Mock vector expressing SKOV3 cells rep2 |
| GSM1655467 |
Mock vector expressing SKOV3 cells rep1 |
| GSM1655468 |
Mock vector expressing SKOV3 cells treated with TGF-ß rep3 |
| GSM1655469 |
VEPH1 expressing SKOV3 cells rep 1 |
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| Relations |
| BioProject |
PRJNA280862 |
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