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Series GSE7540 Query DataSets for GSE7540
Status Public on Apr 26, 2007
Title Gene expression analysis of the human and chimpanzee brain
Platform organism Homo sapiens
Sample organisms Pan troglodytes; Homo sapiens
Experiment type Expression profiling by array
Summary The origin of humans was accompanied by the emergence of new behavioral and cognitive functions, including language and specialized forms of abstract representation. However, the molecular foundations of these human capabilities are poorly understood. Because of the extensive similarity between human and chimpanzee DNA sequences, it has been suggested that many of the key phenotypic differences between species result primarily from alterations in the regulation of genes rather than in their sequences.
To characterize gene expression patterns accross the brain and investigate the genetic basis of human specializations in brain organization and cognition, we used microarrays to quantify the transcript levels of thousands of genes in tissue samples from different brain regions of several human and chimpanzee individuals. Our results indicated that the human brain displays a distinctive pattern of gene expression relative to non-human primates, with higher expression levels for many genes belonging to a wide variety of functional classes. The increased expression of these genes could provide the basis for extensive modifications of cerebral physiology and function in humans, and suggests that the human brain is characterized by elevated levels of neuronal activity.
Keywords: Species comparative study
 
Overall design Gene-expression profiling was performed on 32 tissue samples from different brain regions of a total of 7 humans and 4 chimpanzees. Most samples were hybridized to a single independent arrays, but in a few cases 2 replicates from the same sample were performed, totaling 37 different arrays.
 
Contributor(s) Cáceres M, Barlow C
Citation(s) 14557539
Submission date Apr 18, 2007
Last update date Dec 13, 2018
Contact name Mario Cáceres
E-mail(s) mario.caceres@crg.es
Phone 34-93-3160233
Fax 34-93-3160099
Organization name Center for Genomic Regulation
Department Genes and Disease Program
Street address Dr. Aiguader 88
City Barcelona
State/province Barcelona
ZIP/Postal code 08003
Country Spain
 
Platforms (1)
GPL8300 [HG_U95Av2] Affymetrix Human Genome U95 Version 2 Array
Samples (37)
GSM182704 Human 813 (Hs1) Frontal Pole
GSM182705 Human 813 (Hs1) Hippocampus
GSM182706 Human 813 (Hs1) Caudate Nucleus
Relations
BioProject PRJNA99371

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Supplementary file Size Download File type/resource
GSE7540_RAW.tar 104.3 Mb (http)(custom) TAR (of CEL, CHP, EXP)
Processed data provided as supplementary file
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