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Status |
Public on Aug 22, 2017 |
Title |
cis-regulatory landscape in ccRCC [cell lines] |
Organism |
Homo sapiens |
Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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Summary |
VHL loss is the most common genetic alteration event in ccRCC, but its effect on epigenetic landscape has not been elucidated previously. By performing histone modifications (H3K27ac, H3K4me1, H3K4me3) from ccRCC cell lines, we describe the genome-wide cis-regulatory landscapes of VHL-deficient ccRCC tumors. We show that ccRCCs exhibit a pervasive gain of enhancers around hypoxic and metabolic transcriptional targets.
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Overall design |
Histone ChIP-Seq in ccRCC cell lines
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Contributor(s) |
Yao X, Tan P |
Citation(s) |
28893800 |
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Submission date |
Aug 26, 2016 |
Last update date |
May 15, 2019 |
Contact name |
Xiaosai Yao |
E-mail(s) |
xiaosai.yao@gmail.com, yao.xiaosai@gene.com
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Phone |
+65 68088271
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Organization name |
Genome Institute of Singapore
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Street address |
60 Biopolis Street, Genome, #02-01
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City |
Singapore |
ZIP/Postal code |
138672 |
Country |
Singapore |
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Platforms (1) |
GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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Samples (39)
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This SubSeries is part of SuperSeries: |
GSE86095 |
VHL deficiency drives enhancer activation of oncogenes in clear cell renal cell carcinoma |
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Relations |
BioProject |
PRJNA340237 |
SRA |
SRP083003 |