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Series GSE8671 Query DataSets for GSE8671
Status Public on Aug 03, 2007
Title Transcriptome profile of human colorectal adenomas.
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Background: Colorectal cancers are believed to arise predominantly from adenomas. Although these precancerous lesions have been subjected to extensive clinical, pathological, and molecular analyses, little is currently known about the global gene expression changes accompanying their formation. Results: To characterize the molecular processes underlying the transformation of normal colonic epithelium, we compared the transcriptomes of 32 prospectively collected adenomas with those of normal mucosa from the same individuals. Important differences emerged not only between the expression profiles of normal and adenomatous tissues, but also between those of small and large adenomas. A key feature of the transformation process was the remodeling of the Wnt pathway reflected in patent over- and underexpression of 78 known components of this signaling cascade. Conclusions: Our transcriptomic profiles of normal colonic mucosa and colorectal adenomas shed new light on the early stages of colorectal tumorigenesis.
Keywords: tissue comparison
 
Overall design Pedunculated, sporadic colorectal polyps and corresponding normal mucosa were obtained during colonoscopies. The tissues were collected prospectively with informed patient consent and the approval of the local Human Research Ethics Committee.
 
Contributor(s) Marra G, Sabates J, Rehrauer H
Citation(s) 18171984
Submission date Aug 02, 2007
Last update date Mar 25, 2019
Contact name Giancarlo Marra
E-mail(s) marra@imcr.uzh.ch
Phone 0041 44 6353472
Fax 0041 44 6353484
Organization name University of Zurich
Department Molecular Cancer Research
Street address Winterthurerstrasse 190
City Zurich
ZIP/Postal code 8057
Country Switzerland
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (64)
GSM215051 Biopsy of the normal mucosa of the colon from patient #1
GSM215052 Biopsy of the normal mucosa of the colon from patient #2
GSM215053 Biopsy of the normal mucosa of the colon from patient #3
Relations
BioProject PRJNA101881

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE8671_RAW.tar 558.0 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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