|
| Status |
Public on Jun 11, 2018 |
| Title |
Gene expression changes in white adipose tissue from Ing1- and Gadd45a- single- or double-knockout mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
ING1b and GADD45a are nuclear proteins involved in the regulation of cell growth, apoptosis and DNA repair. We previously found that ING1b is essential to target GADD45a-mediated active DNA-demethylation via TET1 to specific loci. Hence, GADD45a and ING1 play a crucial role in epigenetic gene regulation. In order to study the physiological role of ING1-GADD45a on gene expression regulation, we compared the expression profiles of white adipose tissue (WAT) from wildtype, Ing1-/-, Gadd45-/- and double-knockout (DKO) mice.
|
| |
|
| Overall design |
WAT gene expression profiling in all 4 genotypes with triplicates consisting of pooled RNA from 3 male mice each.
|
| |
|
| Contributor(s) |
Schäfer A, Mekker B, Mallick M, Vastolo V, Karaulanov E, Sebastian D, von der Lippen C, Epe B, Downes DJ, Scholz C, Niehrs C |
| Citation(s) |
29884649 |
| |
| Submission date |
Jun 02, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Emil Karaulanov |
| Organization name |
Institute of Molecular Biology
|
| Lab |
Bioinformatics Core Facility
|
| Street address |
Ackermannweg 4
|
| City |
Mainz |
| ZIP/Postal code |
55128 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL10787 |
Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Probe Name version) |
|
| Samples (12)
|
|
| This SubSeries is part of SuperSeries: |
| GSE99607 |
Impaired DNA demethylation of C/EBP sites causes premature aging |
|
| Relations |
| BioProject |
PRJNA388888 |
Less...
More...