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Consciousness Disorders

MedGen UID:
1099
Concept ID:
C0009792
Mental or Behavioral Dysfunction
Synonyms: Consciousness Disorder; Disorder of Consciousness; Disorders of Consciousness

Definition

Organic mental disorders in which there is impairment of the ability to maintain awareness of self and environment and to respond to environmental stimuli. Dysfunction of the cerebral hemispheres or brain stem RETICULAR FORMATION may result in this condition. [from MeSH]

Professional guidelines

PubMed

Lefaucheur JP, Antal A, Ayache SS, Benninger DH, Brunelin J, Cogiamanian F, Cotelli M, De Ridder D, Ferrucci R, Langguth B, Marangolo P, Mylius V, Nitsche MA, Padberg F, Palm U, Poulet E, Priori A, Rossi S, Schecklmann M, Vanneste S, Ziemann U, Garcia-Larrea L, Paulus W
Clin Neurophysiol 2017 Jan;128(1):56-92. Epub 2016 Oct 29 doi: 10.1016/j.clinph.2016.10.087. PMID: 27866120
Hodelín-Tablada R
MEDICC Rev 2016 Oct;18(4):43-46. doi: 10.37757/MR2016.V18.N4.9. PMID: 27829654
Lefaucheur JP, André-Obadia N, Antal A, Ayache SS, Baeken C, Benninger DH, Cantello RM, Cincotta M, de Carvalho M, De Ridder D, Devanne H, Di Lazzaro V, Filipović SR, Hummel FC, Jääskeläinen SK, Kimiskidis VK, Koch G, Langguth B, Nyffeler T, Oliviero A, Padberg F, Poulet E, Rossi S, Rossini PM, Rothwell JC, Schönfeldt-Lecuona C, Siebner HR, Slotema CW, Stagg CJ, Valls-Sole J, Ziemann U, Paulus W, Garcia-Larrea L
Clin Neurophysiol 2014 Nov;125(11):2150-2206. Epub 2014 Jun 5 doi: 10.1016/j.clinph.2014.05.021. PMID: 25034472

Recent clinical studies

Etiology

Gaw CE, Osterhoudt KC
Pediatr Emerg Care 2019 Oct;35(10):722-730. doi: 10.1097/PEC.0000000000001946. PMID: 31593052
Eeles E, Burianova H, Pandy S, Pinsker D
Curr Aging Sci 2017;10(2):122-128. doi: 10.2174/1874609809666161004142027. PMID: 27719628
Detyniecki K, Blumenfeld H
Epilepsy Behav 2014 Jan;30:6-9. Epub 2013 Oct 12 doi: 10.1016/j.yebeh.2013.09.018. PMID: 24126026Free PMC Article
Baumann CR, Bassetti CL
Lancet Neurol 2005 Oct;4(10):673-82. doi: 10.1016/S1474-4422(05)70196-4. PMID: 16168936
Cole MG
Am J Geriatr Psychiatry 2004 Jan-Feb;12(1):7-21. PMID: 14729554

Diagnosis

Edlow BL, Gosseries O
Semin Neurol 2022 Jun;42(3):238. Epub 2022 Sep 13 doi: 10.1055/s-0042-1755400. PMID: 36100224
Mehta R; GP trainee, Chinthapalli K; consultant neurologist
BMJ 2019 May 2;365:l1296. doi: 10.1136/bmj.l1296. PMID: 31048343
Tristán B, Gleichgerrcht E, Manes F
Handb Clin Neurol 2015;127:195-204. doi: 10.1016/B978-0-444-52892-6.00013-1. PMID: 25702218
Horton E, Krishnamoorthy S, Reynolds L
BMJ Case Rep 2014 Jul 30;2014 doi: 10.1136/bcr-2014-205336. PMID: 25080547Free PMC Article
Giacino JT, Fins JJ, Laureys S, Schiff ND
Nat Rev Neurol 2014 Feb;10(2):99-114. Epub 2014 Jan 28 doi: 10.1038/nrneurol.2013.279. PMID: 24468878

Therapy

Molteni E, Canas LDS, Briand MM, Estraneo A, Font CC, Formisano R, Fufaeva E, Gosseries O, Howarth RA, Lanteri P, Licandro GI, Magee WL, Veeramuthu V, Wilson P, Yamaki T, Slomine BS; as the Special Interest Group on DoC of the International Brain Injury Association (IBIA-DoC SIG)
Neurology 2023 Aug 8;101(6):e581-e593. Epub 2023 Jun 12 doi: 10.1212/WNL.0000000000207473. PMID: 37308301Free PMC Article
Zhao S, Mehta AS, Zhao M
Cell Mol Life Sci 2020 Jul;77(14):2681-2699. Epub 2020 Jan 23 doi: 10.1007/s00018-019-03446-1. PMID: 31974658Free PMC Article
Thibaut A, Schiff N, Giacino J, Laureys S, Gosseries O
Lancet Neurol 2019 Jun;18(6):600-614. Epub 2019 Apr 16 doi: 10.1016/S1474-4422(19)30031-6. PMID: 31003899
Lefaucheur JP, Antal A, Ayache SS, Benninger DH, Brunelin J, Cogiamanian F, Cotelli M, De Ridder D, Ferrucci R, Langguth B, Marangolo P, Mylius V, Nitsche MA, Padberg F, Palm U, Poulet E, Priori A, Rossi S, Schecklmann M, Vanneste S, Ziemann U, Garcia-Larrea L, Paulus W
Clin Neurophysiol 2017 Jan;128(1):56-92. Epub 2016 Oct 29 doi: 10.1016/j.clinph.2016.10.087. PMID: 27866120
Bodart O, Laureys S, Gosseries O
Semin Neurol 2013 Apr;33(2):83-90. Epub 2013 Jul 25 doi: 10.1055/s-0033-1348965. PMID: 23888393

Prognosis

Edlow BL, Claassen J, Schiff ND, Greer DM
Nat Rev Neurol 2021 Mar;17(3):135-156. Epub 2020 Dec 14 doi: 10.1038/s41582-020-00428-x. PMID: 33318675Free PMC Article
Mehta R; GP trainee, Chinthapalli K; consultant neurologist
BMJ 2019 May 2;365:l1296. doi: 10.1136/bmj.l1296. PMID: 31048343
Eeles E, Burianova H, Pandy S, Pinsker D
Curr Aging Sci 2017;10(2):122-128. doi: 10.2174/1874609809666161004142027. PMID: 27719628
Tristán B, Gleichgerrcht E, Manes F
Handb Clin Neurol 2015;127:195-204. doi: 10.1016/B978-0-444-52892-6.00013-1. PMID: 25702218
Giacino JT, Fins JJ, Laureys S, Schiff ND
Nat Rev Neurol 2014 Feb;10(2):99-114. Epub 2014 Jan 28 doi: 10.1038/nrneurol.2013.279. PMID: 24468878

Clinical prediction guides

Ben Salah A, Marois C, Sangare A, Valente M, Sitt J, Rohaut B, Naccache L
Ann Neurol 2023 Apr;93(4):762-767. Epub 2023 Feb 24 doi: 10.1002/ana.26614. PMID: 36754832
Schiff ND
Presse Med 2023 Jun;52(2):104161. Epub 2022 Dec 20 doi: 10.1016/j.lpm.2022.104161. PMID: 36563999
Bodien YG, Barra A, Temkin NR, Barber J, Foreman B, Vassar M, Robertson C, Taylor SR, Markowitz AJ, Manley GT, Giacino JT, Edlow BL; TRACK-TBI Investigators
J Neurotrauma 2021 Dec;38(23):3295-3305. doi: 10.1089/neu.2021.0199. PMID: 34605668Free PMC Article
Edlow BL, Claassen J, Schiff ND, Greer DM
Nat Rev Neurol 2021 Mar;17(3):135-156. Epub 2020 Dec 14 doi: 10.1038/s41582-020-00428-x. PMID: 33318675Free PMC Article
Reuber M, Kurthen M
Behav Neurol 2011;24(1):95-106. doi: 10.3233/BEN-2011-0315. PMID: 21447903Free PMC Article

Recent systematic reviews

Molteni E, Canas LDS, Briand MM, Estraneo A, Font CC, Formisano R, Fufaeva E, Gosseries O, Howarth RA, Lanteri P, Licandro GI, Magee WL, Veeramuthu V, Wilson P, Yamaki T, Slomine BS; as the Special Interest Group on DoC of the International Brain Injury Association (IBIA-DoC SIG)
Neurology 2023 Aug 8;101(6):e581-e593. Epub 2023 Jun 12 doi: 10.1212/WNL.0000000000207473. PMID: 37308301Free PMC Article
Ormseth CH, LaHue SC, Oldham MA, Josephson SA, Whitaker E, Douglas VC
JAMA Netw Open 2023 Jan 3;6(1):e2249950. doi: 10.1001/jamanetworkopen.2022.49950. PMID: 36607634Free PMC Article
Payne LE, Gagnon DJ, Riker RR, Seder DB, Glisic EK, Morris JG, Fraser GL
Crit Care 2017 Nov 14;21(1):276. doi: 10.1186/s13054-017-1856-1. PMID: 29137682Free PMC Article
Bomalaski MN, Claflin ES, Townsend W, Peterson MD
JAMA Neurol 2017 Sep 1;74(9):1130-1139. doi: 10.1001/jamaneurol.2017.1133. PMID: 28655027
Hannawi Y, Lindquist MA, Caffo BS, Sair HI, Stevens RD
Neurology 2015 Mar 24;84(12):1272-80. Epub 2015 Feb 20 doi: 10.1212/WNL.0000000000001404. PMID: 25713001Free PMC Article

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