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Ovarian benign neoplasm

MedGen UID:
14058
•Concept ID:
C0004997
•
Neoplastic Process
Synonyms: Benign neoplasm of ovary; Benign Neoplasm of Ovary; benign neoplasm of ovary; Benign Neoplasm of the Ovary; benign neoplasm of the ovary; Benign Ovarian Neoplasm; benign ovarian neoplasm; Benign ovarian tumor; Benign Ovarian Tumor; benign ovarian tumor; benign ovarian tumour; Benign Tumor of Ovary; benign tumor of ovary; Benign Tumor of the Ovary; benign tumor of the ovary; benign tumour of ovary; benign tumour of the ovary; ovarian benign neoplasm; ovary benign neoplasm
SNOMED CT: Benign ovarian tumor (92260003); Benign neoplasm of ovary (92260003)
 
Monarch Initiative: MONDO:0000646

Definition

A neoplasm that arises from the ovary and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include serous cystadenoma, mucinous cystadenoma, clear cell adenofibroma, benign Brenner tumor, thecoma, and fibroma. [from NCI]

Professional guidelines

PubMed

The prevalence of plasma heparin neutralizing activity and the effect of treatment on it in women with a gynecologic malignancy.
Wentworth P, Weiner C, Abas T, Turner D
Am J Obstet Gynecol 1988 Jul;159(1):194-9. doi: 10.1016/0002-9378(88)90520-0. PMID: 3260749

Recent clinical studies

Etiology

Clinical Challenges in the Management of Malignant Ovarian Germ Cell Tumours.
Saani I, Raj N, Sood R, Ansari S, Mandviwala HA, Sanchez E, Boussios S
Int J Environ Res Public Health 2023 Jun 9;20(12) doi: 10.3390/ijerph20126089. PMID: 37372675Free PMC Article
Ovarian-sparing surgery for ovarian tumors in children: A systematic review and meta-analysis.
Pio L, Abu-Zaid A, Zaghloul T, Halepota HF, Davidoff AM, Losty PD, Abdelhafeez HH
Eur J Surg Oncol 2023 Oct;49(10):106923. Epub 2023 May 18 doi: 10.1016/j.ejso.2023.04.022. PMID: 37211469
Short- and Long-Term Complications of Intraoperative Benign Ovarian Cyst Spillage: A Systematic Review and Meta-analysis.
Eisenberg N, Volodarsky-Perel A, Brochu I, Tremblay C, Gorak E, Hudon E, Fortin S, Kogan L, Rivard C
J Minim Invasive Gynecol 2021 May;28(5):957-970. Epub 2020 Dec 3 doi: 10.1016/j.jmig.2020.11.025. PMID: 33279627
Guideline No. 403: Initial Investigation and Management of Adnexal Masses.
Salvador S, Scott S, Glanc P, Eiriksson L, Jang JH, Sebastianelli A, Dean E
J Obstet Gynaecol Can 2020 Aug;42(8):1021-1029.e3. doi: 10.1016/j.jogc.2019.08.044. PMID: 32736853
Impact of contraception on gynecologic cancers.
Herbst AL, Berek JS
Am J Obstet Gynecol 1993 Jun;168(6 Pt 2):1980-5. doi: 10.1016/s0002-9378(12)90938-2. PMID: 8512041

Diagnosis

Malignant transformation of mature cystic teratoma of the ovary.
Atwi D, Kamal M, Quinton M, Hassell LA
J Obstet Gynaecol Res 2022 Dec;48(12):3068-3076. Epub 2022 Sep 2 doi: 10.1111/jog.15409. PMID: 36053141
Brenner tumors.
Costeira FS, Félix A, Cunha TM
Br J Radiol 2022 Feb 1;95(1130):20210687. Epub 2021 Dec 20 doi: 10.1259/bjr.20210687. PMID: 34928171Free PMC Article
Ovarian neoplasms of childhood.
Lala SV, Strubel N
Pediatr Radiol 2019 Oct;49(11):1463-1475. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04456-8. PMID: 31620847
Mucinous Neoplasms of the Ovary: Radiologic-Pathologic Correlation.
Marko J, Marko KI, Pachigolla SL, Crothers BA, Mattu R, Wolfman DJ
Radiographics 2019 Jul-Aug;39(4):982-997. doi: 10.1148/rg.2019180221. PMID: 31283462Free PMC Article
Ovarian borderline tumors in the 2014 WHO classification: evolving concepts and diagnostic criteria.
Hauptmann S, Friedrich K, Redline R, Avril S
Virchows Arch 2017 Feb;470(2):125-142. Epub 2016 Dec 27 doi: 10.1007/s00428-016-2040-8. PMID: 28025670Free PMC Article

Therapy

Immuno-Oncology for Gynecologic Malignancies.
How JA, Patel A, Jazaeri AA
Adv Exp Med Biol 2021;1342:193-232. doi: 10.1007/978-3-030-79308-1_6. PMID: 34972966
Primary cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy (HIPEC) for FIGO stage III epithelial ovarian cancer: OVHIPEC-2, a phase III randomized clinical trial.
Koole S, van Stein R, Sikorska K, Barton D, Perrin L, Brennan D, Zivanovic O, Mosgaard BJ, Fagotti A, Colombo PE, Sonke G, Driel WJV; OVHIPEC-2 Steering Committee and the Dutch OVHIPEC group
Int J Gynecol Cancer 2020 Jun;30(6):888-892. Epub 2020 Mar 23 doi: 10.1136/ijgc-2020-001231. PMID: 32205449Free PMC Article
Fertility Preservation in Patients With Cancer: ASCO Clinical Practice Guideline Update.
Oktay K, Harvey BE, Partridge AH, Quinn GP, Reinecke J, Taylor HS, Wallace WH, Wang ET, Loren AW
J Clin Oncol 2018 Jul 1;36(19):1994-2001. Epub 2018 Apr 5 doi: 10.1200/JCO.2018.78.1914. PMID: 29620997
Surgical management of recurrent ovarian cancer.
Suh DH, Kim HS, Chang SJ, Bristow RE
Gynecol Oncol 2016 Aug;142(2):357-67. Epub 2016 May 10 doi: 10.1016/j.ygyno.2016.04.537. PMID: 27130407
Survival analysis part I: basic concepts and first analyses.
Clark TG, Bradburn MJ, Love SB, Altman DG
Br J Cancer 2003 Jul 21;89(2):232-8. doi: 10.1038/sj.bjc.6601118. PMID: 12865907Free PMC Article

Prognosis

Ovarian cancer today and tomorrow: A global assessment by world region and Human Development Index using GLOBOCAN 2020.
Cabasag CJ, Fagan PJ, Ferlay J, Vignat J, Laversanne M, Liu L, van der Aa MA, Bray F, Soerjomataram I
Int J Cancer 2022 Nov 1;151(9):1535-1541. Epub 2022 Mar 30 doi: 10.1002/ijc.34002. PMID: 35322413
Antitumor activity and safety of pembrolizumab in patients with advanced recurrent ovarian cancer: results from the phase II KEYNOTE-100 study.
Matulonis UA, Shapira-Frommer R, Santin AD, Lisyanskaya AS, Pignata S, Vergote I, Raspagliesi F, Sonke GS, Birrer M, Provencher DM, Sehouli J, Colombo N, González-Martín A, Oaknin A, Ottevanger PB, Rudaitis V, Katchar K, Wu H, Keefe S, Ruman J, Ledermann JA
Ann Oncol 2019 Jul 1;30(7):1080-1087. doi: 10.1093/annonc/mdz135. PMID: 31046082
Bevacizumab-induced bowel perforation.
Sliesoraitis S, Tawfik B
J Am Osteopath Assoc 2011 Jul;111(7):437-41. PMID: 21803880
Epidemiology of ovarian cancer: a summary review.
La Vecchia C
Eur J Cancer Prev 2001 Apr;10(2):125-9. doi: 10.1097/00008469-200104000-00002. PMID: 11330452
The epidemiology of ovarian cancer.
Tortolero-Luna G, Mitchell MF
J Cell Biochem Suppl 1995;23:200-7. doi: 10.1002/jcb.240590927. PMID: 8747397

Clinical prediction guides

Reducing Unnecessary Oophorectomies for Benign Ovarian Neoplasms in Pediatric Patients.
Minneci PC, Bergus KC, Lutz C, Aldrink J, Bence C, Breech L, Dillon PA, Downard C, Ehrlich PF, Fallat M, Fraser JD, Grabowski J, Helmrath M, Hertweck P, Hewitt G, Hirschl RB, Kabre R, Lal DR, Landman M, Leys C, Mak G, Markel T, Pressey J, Raiji M, Rymeski B, Saito J, Sato TT, St Peter SD, Cooper J, Deans K; Midwest Pediatric Surgery Consortium
JAMA 2023 Oct 3;330(13):1247-1254. doi: 10.1001/jama.2023.17183. PMID: 37787794Free PMC Article
Chemotherapy Response Score: Development and Validation of a System to Quantify Histopathologic Response to Neoadjuvant Chemotherapy in Tubo-Ovarian High-Grade Serous Carcinoma.
Böhm S, Faruqi A, Said I, Lockley M, Brockbank E, Jeyarajah A, Fitzpatrick A, Ennis D, Dowe T, Santos JL, Cook LS, Tinker AV, Le ND, Gilks CB, Singh N
J Clin Oncol 2015 Aug 1;33(22):2457-63. Epub 2015 Jun 29 doi: 10.1200/JCO.2014.60.5212. PMID: 26124480
Ovarian incidentaloma.
Solnik MJ, Alexander C
Best Pract Res Clin Endocrinol Metab 2012 Feb;26(1):105-16. doi: 10.1016/j.beem.2011.07.002. PMID: 22305456
A laparoscopy-based score to predict surgical outcome in patients with advanced ovarian carcinoma: a pilot study.
Fagotti A, Ferrandina G, Fanfani F, Ercoli A, Lorusso D, Rossi M, Scambia G
Ann Surg Oncol 2006 Aug;13(8):1156-61. Epub 2006 Jun 21 doi: 10.1245/ASO.2006.08.021. PMID: 16791447
Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach.
DeLong ER, DeLong DM, Clarke-Pearson DL
Biometrics 1988 Sep;44(3):837-45. PMID: 3203132

Recent systematic reviews

Hyperthermic intraperitoneal chemotherapy (HIPEC) for the management of primary advanced and recurrent ovarian cancer: a systematic review and meta-analysis of randomized trials.
Filis P, Mauri D, Markozannes G, Tolia M, Filis N, Tsilidis K
ESMO Open 2022 Oct;7(5):100586. Epub 2022 Sep 16 doi: 10.1016/j.esmoop.2022.100586. PMID: 36116421Free PMC Article
Anti-Müllerian hormone as a marker of ovarian reserve and premature ovarian insufficiency in children and women with cancer: a systematic review.
Anderson RA, Cameron D, Clatot F, Demeestere I, Lambertini M, Nelson SM, Peccatori F
Hum Reprod Update 2022 May 2;28(3):417-434. doi: 10.1093/humupd/dmac004. PMID: 35199161Free PMC Article
Artificial intelligence in gynecologic cancers: Current status and future challenges - A systematic review.
Akazawa M, Hashimoto K
Artif Intell Med 2021 Oct;120:102164. Epub 2021 Sep 3 doi: 10.1016/j.artmed.2021.102164. PMID: 34629152
BRCA Genes and Related Cancers: A Meta-Analysis from Epidemiological Cohort Studies.
Lee YC, Lee YL, Li CY
Medicina (Kaunas) 2021 Aug 30;57(9) doi: 10.3390/medicina57090905. PMID: 34577828Free PMC Article
Germline and Somatic Tumor Testing in Epithelial Ovarian Cancer: ASCO Guideline.
Konstantinopoulos PA, Norquist B, Lacchetti C, Armstrong D, Grisham RN, Goodfellow PJ, Kohn EC, Levine DA, Liu JF, Lu KH, Sparacio D, Annunziata CM
J Clin Oncol 2020 Apr 10;38(11):1222-1245. Epub 2020 Jan 27 doi: 10.1200/JCO.19.02960. PMID: 31986064Free PMC Article

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