U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Metastatic Malignant Neoplasm in the Hypopharynx

MedGen UID:
146892
•Concept ID:
C0684964
•
Neoplastic Process
Synonyms: Metastatic malignant neoplasm of hypopharynx; Metastatic malignant neoplasm to hypopharynx; Metastatic Malignant Neoplasm to the Hypopharynx; Metastatic Neoplasm to the Hypopharynx; Metastatic Tumor to the Hypopharynx; Secondary malignant neoplasm of hypopharynx
SNOMED CT: Secondary malignant neoplasm of hypopharynx (94334003); Metastatic malignant neoplasm to hypopharynx (94334003); Metastatic malignant neoplasm of hypopharynx (94334003)

Definition

A malignant neoplasm that has spread to the hypopharynx from another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Hypopharynx

Professional guidelines

PubMed

Machine Learning-Guided Adjuvant Treatment of Head and Neck Cancer.
Howard FM, Kochanny S, Koshy M, Spiotto M, Pearson AT
JAMA Netw Open 2020 Nov 2;3(11):e2025881. doi: 10.1001/jamanetworkopen.2020.25881. PMID: 33211108Free PMC Article
Treatment Options for Hypopharyngeal Cancer.
Eckel HE, Bradley PJ
Adv Otorhinolaryngol 2019;83:47-53. Epub 2019 Feb 12 doi: 10.1159/000492308. PMID: 30943512
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Recent clinical studies

Etiology

Phase II Clinical Trial of Neoadjuvant and Adjuvant Pembrolizumab in Resectable Local-Regionally Advanced Head and Neck Squamous Cell Carcinoma.
Wise-Draper TM, Gulati S, Palackdharry S, Hinrichs BH, Worden FP, Old MO, Dunlap NE, Kaczmar JM, Patil Y, Riaz MK, Tang A, Mark J, Zender C, Gillenwater AM, Bell D, Kurtzweil N, Mathews M, Allen CL, Mierzwa ML, Casper K, Jandarov R, Medvedovic M, Lee JJ, Harun N, Takiar V, Gillison M
Clin Cancer Res 2022 Apr 1;28(7):1345-1352. doi: 10.1158/1078-0432.CCR-21-3351. PMID: 35338369Free PMC Article
Machine Learning-Guided Adjuvant Treatment of Head and Neck Cancer.
Howard FM, Kochanny S, Koshy M, Spiotto M, Pearson AT
JAMA Netw Open 2020 Nov 2;3(11):e2025881. doi: 10.1001/jamanetworkopen.2020.25881. PMID: 33211108Free PMC Article
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243
Long-term Results of a Multicenter Randomized Phase III Trial of Induction Chemotherapy With Cisplatin, 5-fluorouracil, ± Docetaxel for Larynx Preservation.
Janoray G, Pointreau Y, Garaud P, Chapet S, Alfonsi M, Sire C, Jadaud E, Calais G
J Natl Cancer Inst 2016 Apr;108(4) Epub 2015 Dec 16 doi: 10.1093/jnci/djv368. PMID: 26681800
Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501).
Bernier J, Cooper JS, Pajak TF, van Glabbeke M, Bourhis J, Forastiere A, Ozsahin EM, Jacobs JR, Jassem J, Ang KK, Lefèbvre JL
Head Neck 2005 Oct;27(10):843-50. doi: 10.1002/hed.20279. PMID: 16161069

Diagnosis

Xevinapant or placebo plus chemoradiotherapy in locally advanced squamous cell carcinoma of the head and neck: TrilynX phase III study design.
Bourhis J, Burtness B, Licitra LF, Nutting C, Schoenfeld JD, Omar M, Bouisset F, Nauwelaerts H, Urfer Y, Zanna C, Cohen EE
Future Oncol 2022 May;18(14):1669-1678. Epub 2022 Feb 17 doi: 10.2217/fon-2021-1634. PMID: 35172587
Machine Learning-Guided Adjuvant Treatment of Head and Neck Cancer.
Howard FM, Kochanny S, Koshy M, Spiotto M, Pearson AT
JAMA Netw Open 2020 Nov 2;3(11):e2025881. doi: 10.1001/jamanetworkopen.2020.25881. PMID: 33211108Free PMC Article
Treatment Options for Hypopharyngeal Cancer.
Eckel HE, Bradley PJ
Adv Otorhinolaryngol 2019;83:47-53. Epub 2019 Feb 12 doi: 10.1159/000492308. PMID: 30943512
PET-NECK: a multicentre randomised Phase III non-inferiority trial comparing a positron emission tomography-computerised tomography-guided watch-and-wait policy with planned neck dissection in the management of locally advanced (N2/N3) nodal metastases in patients with squamous cell head and neck cancer.
Mehanna H, McConkey CC, Rahman JK, Wong WL, Smith AF, Nutting C, Hartley AG, Hall P, Hulme C, Patel DK, Zeidler SV, Robinson M, Sanghera B, Fresco L, Dunn JA
Health Technol Assess 2017 Apr;21(17):1-122. doi: 10.3310/hta21170. PMID: 28409743Free PMC Article
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Therapy

Phase II Clinical Trial of Neoadjuvant and Adjuvant Pembrolizumab in Resectable Local-Regionally Advanced Head and Neck Squamous Cell Carcinoma.
Wise-Draper TM, Gulati S, Palackdharry S, Hinrichs BH, Worden FP, Old MO, Dunlap NE, Kaczmar JM, Patil Y, Riaz MK, Tang A, Mark J, Zender C, Gillenwater AM, Bell D, Kurtzweil N, Mathews M, Allen CL, Mierzwa ML, Casper K, Jandarov R, Medvedovic M, Lee JJ, Harun N, Takiar V, Gillison M
Clin Cancer Res 2022 Apr 1;28(7):1345-1352. doi: 10.1158/1078-0432.CCR-21-3351. PMID: 35338369Free PMC Article
Machine Learning-Guided Adjuvant Treatment of Head and Neck Cancer.
Howard FM, Kochanny S, Koshy M, Spiotto M, Pearson AT
JAMA Netw Open 2020 Nov 2;3(11):e2025881. doi: 10.1001/jamanetworkopen.2020.25881. PMID: 33211108Free PMC Article
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243
Long-term Results of a Multicenter Randomized Phase III Trial of Induction Chemotherapy With Cisplatin, 5-fluorouracil, ± Docetaxel for Larynx Preservation.
Janoray G, Pointreau Y, Garaud P, Chapet S, Alfonsi M, Sire C, Jadaud E, Calais G
J Natl Cancer Inst 2016 Apr;108(4) Epub 2015 Dec 16 doi: 10.1093/jnci/djv368. PMID: 26681800
Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501).
Bernier J, Cooper JS, Pajak TF, van Glabbeke M, Bourhis J, Forastiere A, Ozsahin EM, Jacobs JR, Jassem J, Ang KK, Lefèbvre JL
Head Neck 2005 Oct;27(10):843-50. doi: 10.1002/hed.20279. PMID: 16161069

Prognosis

Comparative analysis of immune infiltrates in head and neck cancers across anatomical sites.
Muijlwijk T, Nijenhuis DNLM, Ganzevles SH, Brink A, Ke C, Fass JN, Rajamanickam V, Leemans CR, Koguchi Y, Fox BA, Poell JB, Brakenhoff RH, van de Ven R
J Immunother Cancer 2024 Jan 11;12(1) doi: 10.1136/jitc-2023-007573. PMID: 38212122Free PMC Article
Machine Learning-Guided Adjuvant Treatment of Head and Neck Cancer.
Howard FM, Kochanny S, Koshy M, Spiotto M, Pearson AT
JAMA Netw Open 2020 Nov 2;3(11):e2025881. doi: 10.1001/jamanetworkopen.2020.25881. PMID: 33211108Free PMC Article
PET-NECK: a multicentre randomised Phase III non-inferiority trial comparing a positron emission tomography-computerised tomography-guided watch-and-wait policy with planned neck dissection in the management of locally advanced (N2/N3) nodal metastases in patients with squamous cell head and neck cancer.
Mehanna H, McConkey CC, Rahman JK, Wong WL, Smith AF, Nutting C, Hartley AG, Hall P, Hulme C, Patel DK, Zeidler SV, Robinson M, Sanghera B, Fresco L, Dunn JA
Health Technol Assess 2017 Apr;21(17):1-122. doi: 10.3310/hta21170. PMID: 28409743Free PMC Article
Long-term Results of a Multicenter Randomized Phase III Trial of Induction Chemotherapy With Cisplatin, 5-fluorouracil, ± Docetaxel for Larynx Preservation.
Janoray G, Pointreau Y, Garaud P, Chapet S, Alfonsi M, Sire C, Jadaud E, Calais G
J Natl Cancer Inst 2016 Apr;108(4) Epub 2015 Dec 16 doi: 10.1093/jnci/djv368. PMID: 26681800
Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501).
Bernier J, Cooper JS, Pajak TF, van Glabbeke M, Bourhis J, Forastiere A, Ozsahin EM, Jacobs JR, Jassem J, Ang KK, Lefèbvre JL
Head Neck 2005 Oct;27(10):843-50. doi: 10.1002/hed.20279. PMID: 16161069

Clinical prediction guides

Comparative analysis of immune infiltrates in head and neck cancers across anatomical sites.
Muijlwijk T, Nijenhuis DNLM, Ganzevles SH, Brink A, Ke C, Fass JN, Rajamanickam V, Leemans CR, Koguchi Y, Fox BA, Poell JB, Brakenhoff RH, van de Ven R
J Immunother Cancer 2024 Jan 11;12(1) doi: 10.1136/jitc-2023-007573. PMID: 38212122Free PMC Article
Machine Learning-Guided Adjuvant Treatment of Head and Neck Cancer.
Howard FM, Kochanny S, Koshy M, Spiotto M, Pearson AT
JAMA Netw Open 2020 Nov 2;3(11):e2025881. doi: 10.1001/jamanetworkopen.2020.25881. PMID: 33211108Free PMC Article
Small Cell Carcinoma in the Head and Neck.
Wakasaki T, Yasumatsu R, Masuda M, Matsuo M, Tamae A, Kubo K, Kogo R, Uchi R, Taura M, Nakagawa T
Ann Otol Rhinol Laryngol 2019 Nov;128(11):1006-1012. Epub 2019 Jun 4 doi: 10.1177/0003489419853601. PMID: 31161776
PET-NECK: a multicentre randomised Phase III non-inferiority trial comparing a positron emission tomography-computerised tomography-guided watch-and-wait policy with planned neck dissection in the management of locally advanced (N2/N3) nodal metastases in patients with squamous cell head and neck cancer.
Mehanna H, McConkey CC, Rahman JK, Wong WL, Smith AF, Nutting C, Hartley AG, Hall P, Hulme C, Patel DK, Zeidler SV, Robinson M, Sanghera B, Fresco L, Dunn JA
Health Technol Assess 2017 Apr;21(17):1-122. doi: 10.3310/hta21170. PMID: 28409743Free PMC Article
Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival.
Bonner JA, Harari PM, Giralt J, Cohen RB, Jones CU, Sur RK, Raben D, Baselga J, Spencer SA, Zhu J, Youssoufian H, Rowinsky EK, Ang KK
Lancet Oncol 2010 Jan;11(1):21-8. Epub 2009 Nov 10 doi: 10.1016/S1470-2045(09)70311-0. PMID: 19897418

Recent systematic reviews

Salvage surgery for recurrent or residual hypopharyngeal squamous cell carcinoma: A systematic review.
Cooke PV, Wu MP, Rathi VK, Chen S, Kappauf C, Roof SA, Lin DT, Deschler DG
Head Neck 2024 Nov;46(11):2725-2736. Epub 2024 May 8 doi: 10.1002/hed.27794. PMID: 38716810
Nodal tumor volume as a prognostic factor for head and neck squamous cell carcinoma: a systematic review.
Moumoulidis PT, Pavlopoulou A, Ünal R, Mavragani I, Georgakilas AG, Kyrodimos E
Front Biosci (Landmark Ed) 2021 Jul 30;26(7):235-245. doi: 10.52586/4937. PMID: 34340270
Carcinomas of the hypopharynx and cervical esophagus: A systematic review and quality of evidence assessment.
Schizas D, Theochari NA, Ziogas IA, Economopoulos KP, Mylonas KS
J BUON 2021 Jan-Feb;26(1):39-50. PMID: 33721430

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...