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Abnormal granulocyte morphology

MedGen UID:: 1634946
•Concept ID:: C4551567
•: Finding

Synonym:	Abnormality of granulocytes

HPO:	HP:0001911

Definition

Any structural abnormality or abnormal count of granulocytes. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal granulocyte morphology

Phenotypic abnormality
- Abnormality of the immune system
  - Abnormal immune system morphology
    - Abnormal cellular immune system morphology
      - Abnormal leukocyte morphology
        Abnormal myeloid leukocyte morphology
        Abnormal granulocyte morphology
        Abnormal basophil morphology
        Abnormal eosinophil morphology
        Eosinophil nuclear hypersegmentation
        Abnormal mast cell morphology
        Increased proportion of CD25+ mast cells
        Mastocytosis
        Benign mastocytoma
        Cutaneous mastocytosis
        Extracutaneous mastocytoma
        Hepatic mastocytosis
        Mast cell sarcoma
        Systemic mast cell disease
        Abnormality of neutrophils
        Abnormal neutrophil morphology
        Absent neutrophil specific granules
        Diminished neutrophil myeloperoxidase activity
        Giant neutrophil granules
        Hypersegmentation of neutrophil nuclei
        Hyposegmentation of neutrophil nuclei
        Increased neutrophil mitochondria
        Increased neutrophil nuclear projections
        Increased neutrophil ribosomes
        Neutrophil inclusion bodies
        Pyknotic bone marrow neutrophils
        Abnormality of neutrophil physiology
        Abnormal L-selectin shedding
        Impaired neutrophil bactericidal activity
        Reduction of neutrophil motility

Professional guidelines

PubMed

Pyoderma gangrenosum: a review of pathogenesis and treatment.

Ahn C, Negus D, Huang W
Expert Rev Clin Immunol 2018 Mar;14(3):225-233. Epub 2018 Feb 13 doi: 10.1080/1744666X.2018.1438269. PMID: 29406827

Autoimmune Neutropenia Updates: Etiology, Pathology, and Treatment.

Afzal W, Owlia MB, Hasni S, Newman KA
South Med J 2017 Apr;110(4):300-307. doi: 10.14423/SMJ.0000000000000637. PMID: 28376530

Recurrent miscarriage: causes, evaluation and management.

Garrido-Gimenez C, Alijotas-Reig J
Postgrad Med J 2015 Mar;91(1073):151-62. Epub 2015 Feb 13 doi: 10.1136/postgradmedj-2014-132672. PMID: 25681385

Recent clinical studies

Etiology

Chronic myelomonocytic leukemia: clinical features, cytogenetics, and prognosis in 30 consecutive cases.

Alessandrino EP, Orlandi E, Brusamolino E, Lazzarino M, Morra E, Castagnola C, Bernasconi C
Hematol Oncol 1985 Apr-Jun;3(2):147-55. doi: 10.1002/hon.2900030206. PMID: 3860466

Diagnosis

Chronic myelomonocytic leukemia: clinical features, cytogenetics, and prognosis in 30 consecutive cases.

Alessandrino EP, Orlandi E, Brusamolino E, Lazzarino M, Morra E, Castagnola C, Bernasconi C
Hematol Oncol 1985 Apr-Jun;3(2):147-55. doi: 10.1002/hon.2900030206. PMID: 3860466

Prognosis

Chronic myelomonocytic leukemia: clinical features, cytogenetics, and prognosis in 30 consecutive cases.

Alessandrino EP, Orlandi E, Brusamolino E, Lazzarino M, Morra E, Castagnola C, Bernasconi C
Hematol Oncol 1985 Apr-Jun;3(2):147-55. doi: 10.1002/hon.2900030206. PMID: 3860466

Clinical prediction guides

Chronic myelomonocytic leukemia: clinical features, cytogenetics, and prognosis in 30 consecutive cases.

Alessandrino EP, Orlandi E, Brusamolino E, Lazzarino M, Morra E, Castagnola C, Bernasconi C
Hematol Oncol 1985 Apr-Jun;3(2):147-55. doi: 10.1002/hon.2900030206. PMID: 3860466

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