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Abnormality of neutrophils

MedGen UID:: 488900
•Concept ID:: C0427515
•: Finding

Synonyms:	Abnormality of neutrophil; Abnormality of polymorphonuclear neutrophils; Neutrophil abnormality
SNOMED CT:	Neutrophil abnormality (250274006)

HPO:	HP:0001874

Definition

A neutrophil abnormality. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormality of neutrophils

Abnormality of the immune system
- Abnormal immune system morphology
  - Abnormal cellular immune system morphology
    - Abnormal leukocyte morphology
      - Abnormal myeloid leukocyte morphology
        Abnormal granulocyte morphology
        Abnormality of neutrophils
        Abnormal neutrophil morphology
        Absent neutrophil specific granules
        Absent neutrophil lactoferrin
        Diminished neutrophil myeloperoxidase activity
        Giant neutrophil granules
        Hypersegmentation of neutrophil nuclei
        Hyposegmentation of neutrophil nuclei
        Increased neutrophil mitochondria
        Increased neutrophil nuclear projections
        Increased neutrophil ribosomes
        Neutrophil inclusion bodies
        Leukocyte inclusion bodies
        Pyknotic bone marrow neutrophils
        Abnormality of neutrophil physiology
        Abnormal L-selectin shedding
        Impaired neutrophil bactericidal activity
        Impaired neutrophil killing of staphylococci
        Impaired oxidative burst
        Reduction of neutrophil motility
        Impaired neutrophil chemotaxis

Conditions with this feature

Pelger-Huët anomaly

MedGen UID:: 10617
•Concept ID:: C0030779
•: Disease or Syndrome

An autosomal dominant inherited condition caused by mutations in the lamin B receptor gene. It is characterized by defects in the neutrophil lobulation, resulting in the presence of dumbbell-shaped neutrophils with bilobed nuclei in the peripheral blood smear.

See: Condition Record

Pelger-Huët anomaly

Professional guidelines

PubMed

Essential thrombocythemia: 2024 update on diagnosis, risk stratification, and management.

Tefferi A, Vannucchi AM, Barbui T
Am J Hematol 2024 Apr;99(4):697-718. Epub 2024 Jan 25 doi: 10.1002/ajh.27216. PMID: 38269572

Polycythemia vera: 2024 update on diagnosis, risk-stratification, and management.

Tefferi A, Barbui T
Am J Hematol 2023 Sep;98(9):1465-1487. Epub 2023 Jun 26 doi: 10.1002/ajh.27002. PMID: 37357958

COPD and biologic treatment: state of the art.

Ferri S, Paoletti G, Pelaia C, Heffler E, Canonica GW, Puggioni F
Curr Opin Allergy Clin Immunol 2023 Aug 1;23(4):309-318. Epub 2023 Jun 20 doi: 10.1097/ACI.0000000000000920. PMID: 37357768

See all (170)

Recent clinical studies

Etiology

Long-term Effects of IL-6 Receptor Blockade Therapy on Regulatory Lymphocytes and Neutrophils in Neuromyelitis Optica Spectrum Disorder.

Matsuoka T, Araki M, Lin Y, Okamoto T, Gold R, Chihara N, Sato W, Kimura A, Tachimori H, Miyamoto K, Kusunoki S, Yamamura T
Neurol Neuroimmunol Neuroinflamm 2024 Jan;11(1) Epub 2023 Oct 20 doi: 10.1212/NXI.0000000000200173. PMID: 37863660 Free PMC Article

Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils.

Huerga Encabo H, Aramburu IV, Garcia-Albornoz M, Piganeau M, Wood H, Song A, Ferrelli A, Sharma A, Minutti CM, Domart MC, Papazoglou D, Gurashi K, Llorian Sopena M, Goldstone R, Fallesen T, Wang Q, Ariza-McNaughton L, Wiseman DH, Batta K, Gupta R, Papayannopoulos V, Bonnet D
Cell Stem Cell 2023 Jun 1;30(6):781-799.e9. doi: 10.1016/j.stem.2023.05.004. PMID: 37267914

Interactions of HIV and Antiretroviral Therapy With Neutrophils and Platelets.

Madzime M, Rossouw TM, Theron AJ, Anderson R, Steel HC
Front Immunol 2021;12:634386. Epub 2021 Mar 12 doi: 10.3389/fimmu.2021.634386. PMID: 33777022 Free PMC Article

Role of Neutrophils in Psoriasis.

Wang WM, Jin HZ
J Immunol Res 2020;2020:3709749. Epub 2020 Jun 5 doi: 10.1155/2020/3709749. PMID: 32587871 Free PMC Article

Disordered haematopoiesis and athero-thrombosis.

Murphy AJ, Tall AR
Eur Heart J 2016 Apr 7;37(14):1113-21. Epub 2016 Feb 10 doi: 10.1093/eurheartj/ehv718. PMID: 26869607 Free PMC Article

See all (2159)

Diagnosis

The lipid-metabolism enzyme ECI2 reduces neutrophil extracellular traps formation for colorectal cancer suppression.

Chen L, Dai P, Liu L, Chen Y, Lu Y, Zheng L, Wang H, Yuan Q, Li X
Nat Commun 2024 Aug 21;15(1):7184. doi: 10.1038/s41467-024-51489-1. PMID: 39169021 Free PMC Article

Changes in coagulation markers in children with Mycoplasma pneumoniae pneumonia and their predictive value for Mycoplasma severity.

Li YT, Zhang J, Wang MZ, Ma YM, Zhi K, Dai FL, Li SJ
Ital J Pediatr 2023 Oct 20;49(1):143. doi: 10.1186/s13052-023-01545-1. PMID: 37858230 Free PMC Article

Computational analysis of peripheral blood smears detects disease-associated cytomorphologies.

de Almeida JG, Gudgin E, Besser M, Dunn WG, Cooper J, Haferlach T, Vassiliou GS, Gerstung M
Nat Commun 2023 Jul 20;14(1):4378. doi: 10.1038/s41467-023-39676-y. PMID: 37474506 Free PMC Article

Neutrophils in critical illness.

McDonald B
Cell Tissue Res 2018 Mar;371(3):607-615. Epub 2017 Dec 15 doi: 10.1007/s00441-017-2752-3. PMID: 29247324

Pathophysiology of ANCA-associated Vasculitis.

Al-Hussain T, Hussein MH, Conca W, Al Mana H, Akhtar M
Adv Anat Pathol 2017 Jul;24(4):226-234. doi: 10.1097/PAP.0000000000000154. PMID: 28537941

See all (2041)

Therapy

Clinical and functional spectrum of RAC2-related immunodeficiency.

Donkó Á, Sharapova SO, Kabat J, Ganesan S, Hauck FH, Bergerson JRE, Marois L, Abbott J, Moshous D, Williams KW, Campbell N, Martin PL, Lagresle-Peyrou C, Trojan T, Kuzmenko NB, Deordieva EA, Raykina EV, Abers MS, Abolhassani H, Barlogis V, Milla C, Hall G, Mousallem T, Church J, Kapoor N, Cros G, Chapdelaine H, Franco-Jarava C, Lopez-Lerma I, Miano M, Leiding JW, Klein C, Stasia MJ, Fischer A, Hsiao KC, Martelius T, Seppänen MRJ, Barmettler S, Walter J, Masmas TN, Mukhina AA, Falcone EL, Kracker S, Shcherbina A, Holland SM, Leto TL, Hsu AP
Blood 2024 Apr 11;143(15):1476-1487. doi: 10.1182/blood.2023022098. PMID: 38194689 Free PMC Article

Long-term Effects of IL-6 Receptor Blockade Therapy on Regulatory Lymphocytes and Neutrophils in Neuromyelitis Optica Spectrum Disorder.

Interactions of HIV and Antiretroviral Therapy With Neutrophils and Platelets.

Madzime M, Rossouw TM, Theron AJ, Anderson R, Steel HC
Front Immunol 2021;12:634386. Epub 2021 Mar 12 doi: 10.3389/fimmu.2021.634386. PMID: 33777022 Free PMC Article

Epidermolysis bullosa acquisita: A comprehensive review.

Kridin K, Kneiber D, Kowalski EH, Valdebran M, Amber KT
Autoimmun Rev 2019 Aug;18(8):786-795. Epub 2019 Jun 7 doi: 10.1016/j.autrev.2019.06.007. PMID: 31181325

Therapeutic implications of 'neutrophilic asthma'.

Nair P, Aziz-Ur-Rehman A, Radford K
Curr Opin Pulm Med 2015 Jan;21(1):33-8. doi: 10.1097/MCP.0000000000000120. PMID: 25415406

See all (1549)

Prognosis

The lipid-metabolism enzyme ECI2 reduces neutrophil extracellular traps formation for colorectal cancer suppression.

Chen L, Dai P, Liu L, Chen Y, Lu Y, Zheng L, Wang H, Yuan Q, Li X
Nat Commun 2024 Aug 21;15(1):7184. doi: 10.1038/s41467-024-51489-1. PMID: 39169021 Free PMC Article

Changes in coagulation markers in children with Mycoplasma pneumoniae pneumonia and their predictive value for Mycoplasma severity.

Li YT, Zhang J, Wang MZ, Ma YM, Zhi K, Dai FL, Li SJ
Ital J Pediatr 2023 Oct 20;49(1):143. doi: 10.1186/s13052-023-01545-1. PMID: 37858230 Free PMC Article

Neutrophils in COVID-19: recent insights and advances.

Li J, Zhang K, Zhang Y, Gu Z, Huang C
Virol J 2023 Aug 2;20(1):169. doi: 10.1186/s12985-023-02116-w. PMID: 37533131 Free PMC Article

NETosis and Neutrophil Extracellular Traps in COVID-19: Immunothrombosis and Beyond.

Zhu Y, Chen X, Liu X
Front Immunol 2022;13:838011. Epub 2022 Mar 2 doi: 10.3389/fimmu.2022.838011. PMID: 35309344 Free PMC Article

Neutrophils in critical illness.

McDonald B
Cell Tissue Res 2018 Mar;371(3):607-615. Epub 2017 Dec 15 doi: 10.1007/s00441-017-2752-3. PMID: 29247324

See all (1378)

Clinical prediction guides

Long-term Effects of IL-6 Receptor Blockade Therapy on Regulatory Lymphocytes and Neutrophils in Neuromyelitis Optica Spectrum Disorder.

NETosis and Neutrophil Extracellular Traps in COVID-19: Immunothrombosis and Beyond.

Zhu Y, Chen X, Liu X
Front Immunol 2022;13:838011. Epub 2022 Mar 2 doi: 10.3389/fimmu.2022.838011. PMID: 35309344 Free PMC Article

What's wrong with neutrophils in lupus?

Tsai CY, Li KJ, Hsieh SC, Liao HT, Yu CL
Clin Exp Rheumatol 2019 Jul-Aug;37(4):684-693. Epub 2018 Nov 19 PMID: 30557133

Neutrophils in critical illness.

McDonald B
Cell Tissue Res 2018 Mar;371(3):607-615. Epub 2017 Dec 15 doi: 10.1007/s00441-017-2752-3. PMID: 29247324

Therapeutic implications of 'neutrophilic asthma'.

Nair P, Aziz-Ur-Rehman A, Radford K
Curr Opin Pulm Med 2015 Jan;21(1):33-8. doi: 10.1097/MCP.0000000000000120. PMID: 25415406

See all (1967)

Recent systematic reviews

Patient-Level Meta-analysis of Clofarabine in Acute Lymphoblastic Leukemia.

Jeha S, Goto H, Baruchel A, Boëlle-Le Corfec E, Geffriaud-Ricouard C, Pieters R, Shin HY
Adv Ther 2023 Dec;40(12):5447-5463. Epub 2023 Oct 11 doi: 10.1007/s12325-023-02696-7. PMID: 37819554 Free PMC Article

Expression of MicroRNAs in Sepsis-Related Organ Dysfunction: A Systematic Review.

Maiese A, Scatena A, Costantino A, Chiti E, Occhipinti C, La Russa R, Di Paolo M, Turillazzi E, Frati P, Fineschi V
Int J Mol Sci 2022 Aug 19;23(16) doi: 10.3390/ijms23169354. PMID: 36012630 Free PMC Article

The 2021 European Alliance of Associations for Rheumatology/American College of Rheumatology points to consider for diagnosis and management of autoinflammatory type I interferonopathies: CANDLE/PRAAS, SAVI and AGS.

Cetin Gedik K, Lamot L, Romano M, Demirkaya E, Piskin D, Torreggiani S, Adang LA, Armangue T, Barchus K, Cordova DR, Crow YJ, Dale RC, Durrant KL, Eleftheriou D, Fazzi EM, Gattorno M, Gavazzi F, Hanson EP, Lee-Kirsch MA, Montealegre Sanchez GA, Neven B, Orcesi S, Ozen S, Poli MC, Schumacher E, Tonduti D, Uss K, Aletaha D, Feldman BM, Vanderver A, Brogan PA, Goldbach-Mansky R
Ann Rheum Dis 2022 May;81(5):601-613. Epub 2022 Jan 27 doi: 10.1136/annrheumdis-2021-221814. PMID: 35086813 Free PMC Article

Biomarkers of acute kidney injury in pediatric cardiac surgery.

Cavalcante CTMB, Cavalcante MB, Castello Branco KMP, Chan T, Maia ICL, Pompeu RG, de Oliveira Telles AC, Brito AKM, Libório AB
Pediatr Nephrol 2022 Jan;37(1):61-78. Epub 2021 May 25 doi: 10.1007/s00467-021-05094-9. PMID: 34036445

Hematological findings and complications of COVID-19.

Terpos E, Ntanasis-Stathopoulos I, Elalamy I, Kastritis E, Sergentanis TN, Politou M, Psaltopoulou T, Gerotziafas G, Dimopoulos MA
Am J Hematol 2020 Jul;95(7):834-847. Epub 2020 May 23 doi: 10.1002/ajh.25829. PMID: 32282949 Free PMC Article

See all (35)

MedGen

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Abnormality of neutrophils

Definition

Term Hierarchy

Conditions with this feature

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Genetic Testing Registry

Clinical resources

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Consumer resources

Reviews

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