U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lacrimal System Non-Hodgkin Lymphoma

MedGen UID:
1784638
•Concept ID:
C5446559
•
Neoplastic Process
Synonyms: Lacrimal System Lymphoma; Primary Lacrimal System Lymphoma; Primary Lacrimal System Non-Hodgkin Lymphoma

Definition

A non-Hodgkin lymphoma that arises from the lacrimal gland or the lacrimal drainage system. The majority of cases are of B-cell type. The most common subtypes are mucosa-associated lymphoid tissue lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma. [from NCI]

Professional guidelines

PubMed

Update on the pathophysiology and treatment of primary Sjögren syndrome.
Baldini C, Fulvio G, La Rocca G, Ferro F
Nat Rev Rheumatol 2024 Aug;20(8):473-491. Epub 2024 Jul 9 doi: 10.1038/s41584-024-01135-3. PMID: 38982205
The role of (18)F-FDG PET/CT in diagnosis and treatment evaluation for ocular adnexal mucosa-associated lymphoid tissue lymphoma.
Wang W, Ni X, Tang T, Wang J, Li Y, Song X
Br J Radiol 2022 Feb 1;95(1130):20210635. Epub 2021 Dec 17 doi: 10.1259/bjr.20210635. PMID: 34919440Free PMC Article
Association of Disease Location and Treatment With Survival in Diffuse Large B-Cell Lymphoma of the Eye and Ocular Adnexal Region.
Ahmed AH, Foster CS, Shields CL
JAMA Ophthalmol 2017 Oct 1;135(10):1062-1068. doi: 10.1001/jamaophthalmol.2017.3286. PMID: 28880986Free PMC Article

Recent clinical studies

Etiology

Lymphoma of the Lacrimal Sac: The Massachusetts Eye and Ear Experience With a Comparison to the Previously Reported Literature.
Neerukonda VK, Stagner AM, Wolkow N
Ophthalmic Plast Reconstr Surg 2022 Jan-Feb 01;38(1):79-86. doi: 10.1097/IOP.0000000000001997. PMID: 34269767
Lacrimal sac lymphoma: A series of Japanese patients.
Sabundayo MS, Takahashi Y, Kakizaki H
Eur J Ophthalmol 2019 Nov;29(6):678-684. Epub 2018 Oct 1 doi: 10.1177/1120672118803510. PMID: 30270644
Overview of benign and malignant lacrimal gland tumors.
Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745
Primary Sjögren's syndrome.
Rischmueller M, Tieu J, Lester S
Best Pract Res Clin Rheumatol 2016 Feb;30(1):189-220. Epub 2016 May 13 doi: 10.1016/j.berh.2016.04.003. PMID: 27421224
W(h)ither orbital pseudotumor?
Agir H, Aburn N, Davis C, MacKinnon C, Tan ST
J Craniofac Surg 2007 Sep;18(5):1148-53. doi: 10.1097/scs.0b013e31814510bb. PMID: 17912101

Diagnosis

Lymphoma of the Lacrimal Sac: The Massachusetts Eye and Ear Experience With a Comparison to the Previously Reported Literature.
Neerukonda VK, Stagner AM, Wolkow N
Ophthalmic Plast Reconstr Surg 2022 Jan-Feb 01;38(1):79-86. doi: 10.1097/IOP.0000000000001997. PMID: 34269767
Overview of benign and malignant lacrimal gland tumors.
Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745
Primary Sjögren's syndrome.
Rischmueller M, Tieu J, Lester S
Best Pract Res Clin Rheumatol 2016 Feb;30(1):189-220. Epub 2016 May 13 doi: 10.1016/j.berh.2016.04.003. PMID: 27421224
Orbital richter syndrome.
Kiratli H, Tarlan B, Uzun S, Tanas Ö, Uner A
Orbit 2013 Dec;32(6):381-3. Epub 2013 Jul 29 doi: 10.3109/01676830.2013.815223. PMID: 23895640
W(h)ither orbital pseudotumor?
Agir H, Aburn N, Davis C, MacKinnon C, Tan ST
J Craniofac Surg 2007 Sep;18(5):1148-53. doi: 10.1097/scs.0b013e31814510bb. PMID: 17912101

Therapy

Update on the pathophysiology and treatment of primary Sjögren syndrome.
Baldini C, Fulvio G, La Rocca G, Ferro F
Nat Rev Rheumatol 2024 Aug;20(8):473-491. Epub 2024 Jul 9 doi: 10.1038/s41584-024-01135-3. PMID: 38982205
Lymphoma of the Lacrimal Gland - An International Multicenter Retrospective Study.
Vest SD, Mikkelsen LH, Holm F, Rasmussen PK, Hindso TG, Knudsen MKH, Coupland SE, Esmaeli B, Finger PT, Graue GF, Grossniklaus HE, Honavar SG, Mulay K, Sjö LD, Sniegowski MC, Vemuganti GK, Thuro BA, Heegaard S
Am J Ophthalmol 2020 Nov;219:107-120. Epub 2020 Jun 20 doi: 10.1016/j.ajo.2020.06.015. PMID: 32574779
Lacrimal sac lymphoma: A series of Japanese patients.
Sabundayo MS, Takahashi Y, Kakizaki H
Eur J Ophthalmol 2019 Nov;29(6):678-684. Epub 2018 Oct 1 doi: 10.1177/1120672118803510. PMID: 30270644
Orbital richter syndrome.
Kiratli H, Tarlan B, Uzun S, Tanas Ö, Uner A
Orbit 2013 Dec;32(6):381-3. Epub 2013 Jul 29 doi: 10.3109/01676830.2013.815223. PMID: 23895640
W(h)ither orbital pseudotumor?
Agir H, Aburn N, Davis C, MacKinnon C, Tan ST
J Craniofac Surg 2007 Sep;18(5):1148-53. doi: 10.1097/scs.0b013e31814510bb. PMID: 17912101

Prognosis

Lymphoma of the Lacrimal Gland - An International Multicenter Retrospective Study.
Vest SD, Mikkelsen LH, Holm F, Rasmussen PK, Hindso TG, Knudsen MKH, Coupland SE, Esmaeli B, Finger PT, Graue GF, Grossniklaus HE, Honavar SG, Mulay K, Sjö LD, Sniegowski MC, Vemuganti GK, Thuro BA, Heegaard S
Am J Ophthalmol 2020 Nov;219:107-120. Epub 2020 Jun 20 doi: 10.1016/j.ajo.2020.06.015. PMID: 32574779
Overview of benign and malignant lacrimal gland tumors.
Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745
Ocular adnexal follicular lymphoma: a multicenter international study.
Rasmussen PK, Coupland SE, Finger PT, Graue GF, Grossniklaus HE, Honavar SG, McKelvie P, Mulay K, Prause JU, Ralfkiaer E, Sjö LD, Heegaard S
JAMA Ophthalmol 2014 Jul;132(7):851-8. doi: 10.1001/jamaophthalmol.2014.376. PMID: 24763920
Orbital richter syndrome.
Kiratli H, Tarlan B, Uzun S, Tanas Ö, Uner A
Orbit 2013 Dec;32(6):381-3. Epub 2013 Jul 29 doi: 10.3109/01676830.2013.815223. PMID: 23895640
Curative radiotherapy for primary orbital lymphoma.
Bhatia S, Paulino AC, Buatti JM, Mayr NA, Wen BC
Int J Radiat Oncol Biol Phys 2002 Nov 1;54(3):818-23. doi: 10.1016/s0360-3016(02)02966-8. PMID: 12377334

Clinical prediction guides

Bilateral Lacrimal Gland Lymphoma - Case Presentation.
Prună VI, Ciuc DM, Dincă VG, Prună VM
Rom J Ophthalmol 2024 Apr-Jun;68(2):191-197. doi: 10.22336/rjo.2024.36. PMID: 39006336Free PMC Article
Lymphoma of the Lacrimal Gland - An International Multicenter Retrospective Study.
Vest SD, Mikkelsen LH, Holm F, Rasmussen PK, Hindso TG, Knudsen MKH, Coupland SE, Esmaeli B, Finger PT, Graue GF, Grossniklaus HE, Honavar SG, Mulay K, Sjö LD, Sniegowski MC, Vemuganti GK, Thuro BA, Heegaard S
Am J Ophthalmol 2020 Nov;219:107-120. Epub 2020 Jun 20 doi: 10.1016/j.ajo.2020.06.015. PMID: 32574779
Follicular lymphoma of the ocular adnexal region: a nation-based study.
Rasmussen PK, Ralfkiaer E, Prause JU, Sjö LD, Specht L, Rossing HH, Siersma VD, Heegaard S
Acta Ophthalmol 2015 Mar;93(2):184-91. Epub 2014 Aug 13 doi: 10.1111/aos.12525. PMID: 25125069
Curative radiotherapy for primary orbital lymphoma.
Bhatia S, Paulino AC, Buatti JM, Mayr NA, Wen BC
Int J Radiat Oncol Biol Phys 2002 Nov 1;54(3):818-23. doi: 10.1016/s0360-3016(02)02966-8. PMID: 12377334
Orbital and adnexal involvement in systemic non-Hodgkin's lymphoma.
Bairey O, Kremer I, Rakowsky E, Hadar H, Shaklai M
Cancer 1994 May 1;73(9):2395-9. doi: 10.1002/1097-0142(19940501)73:9<2395::aid-cncr2820730924>3.0.co;2-v. PMID: 8168043

Recent systematic reviews

NK/T-cell Lymphoma With Orbital Involvement: A Case Report and Systematic Review of the Literature.
Dhodapkar RM, Spadaro JZ, Heng JS, Sinard JH, Lee YH, Habib LA, Pointdujour-Lim R
Ophthalmic Plast Reconstr Surg 2023 Jul-Aug 01;39(4):316-327. Epub 2023 Jan 24 doi: 10.1097/IOP.0000000000002317. PMID: 36692957

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...