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Conjunctival Mucosa-Associated Lymphoid Tissue Lymphoma

MedGen UID:
1785596
•Concept ID:
C5446514
•
Neoplastic Process

Definition

A mucosa-associated lymphoid tissue lymphoma affecting the conjunctiva. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVConjunctival Mucosa-Associated Lymphoid Tissue Lymphoma

Professional guidelines

PubMed

Intralesional Rituximab Injection for Low-Grade Conjunctival Lymphoma Management.
Demirci H, Ozgonul C, Diniz Grisolia AB, Elner VM
Ophthalmology 2020 Sep;127(9):1270-1273. Epub 2020 Mar 18 doi: 10.1016/j.ophtha.2020.03.014. PMID: 32336490
Ocular adnexal marginal zone lymphoma: Clinical presentation, pathogenesis, diagnosis, prognosis, and treatment.
Sassone M, Ponzoni M, Ferreri AJ
Best Pract Res Clin Haematol 2017 Mar-Jun;30(1-2):118-130. Epub 2016 Dec 7 doi: 10.1016/j.beha.2016.11.002. PMID: 28288706
A reappraisal of the diagnostic and therapeutic management of uncommon histologies of primary ocular adnexal lymphoma.
Ponzoni M, Govi S, Licata G, Mappa S, Giordano Resti A, Politi LS, Spagnuolo L, Di Cairano E, Doglioni C, Ferreri AJ
Oncologist 2013;18(7):876-84. Epub 2013 Jun 28 doi: 10.1634/theoncologist.2012-0425. PMID: 23814042Free PMC Article

Recent clinical studies

Etiology

Clinical value of magnetic resonance imaging and other baseline testing for conjunctival mucosa-associated lymphoid tissue lymphoma.
Nasser QJ, Pfeiffer ML, Romaguera J, Fowler N, Debnam JM, Samaniego F, El-Sawy T, McLaughlin P, Bakhoum MF, Esmaeli B
Leuk Lymphoma 2014 May;55(5):1013-7. Epub 2013 Aug 28 doi: 10.3109/10428194.2013.826353. PMID: 23879202
Intralesional interferon-α for conjunctival mucosa-associated lymphoid tissue lymphoma: long-term results.
Blasi MA, Tiberti AC, Valente P, Laguardia M, Sammarco MG, Balestrazzi A, Larocca LM, Balestrazzi E
Ophthalmology 2012 Mar;119(3):494-500. Epub 2012 Jan 5 doi: 10.1016/j.ophtha.2011.09.008. PMID: 22226154
Role of Helicobacter pylori in conjunctival mucosa-associated lymphoid tissue lymphoma.
Sjö NC, Foegh P, Juhl BR, Nilsson HO, Prause JU, Ralfkiaer E, Wadström T, Heegaard S
Ophthalmology 2007 Jan;114(1):182-6. doi: 10.1016/j.ophtha.2006.09.020. PMID: 17198854
Fornix and conjunctiva reconstruction by amniotic membrane in a patient with conjunctival mucosa-associated lymphoid tissue lymphoma.
Kobayashi A, Takahira M, Yamada A, Segawa Y, Tanahashi T, Shirao Y, Nonomura A
Jpn J Ophthalmol 2002 May-Jun;46(3):346-8. doi: 10.1016/s0021-5155(02)00476-8. PMID: 12063048
Local chemotherapy with interferon-alpha for conjunctival mucosa-associated lymphoid tissue lymphoma: a preliminary report.
Blasi MA, Gherlinzoni F, Calvisi G, Sasso P, Tani M, Cellini M, Balestrazzi E
Ophthalmology 2001 Mar;108(3):559-62. doi: 10.1016/s0161-6420(00)00591-1. PMID: 11237911

Diagnosis

Conjunctival Lymphoma in a Patient on Fingolimod for Relapsing-Remitting Multiple Sclerosis.
Christopher KL, Elner VM, Demirci H
Ophthalmic Plast Reconstr Surg 2017 May/Jun;33(3):e73-e75. doi: 10.1097/IOP.0000000000000774. PMID: 27533512
Clinical value of magnetic resonance imaging and other baseline testing for conjunctival mucosa-associated lymphoid tissue lymphoma.
Nasser QJ, Pfeiffer ML, Romaguera J, Fowler N, Debnam JM, Samaniego F, El-Sawy T, McLaughlin P, Bakhoum MF, Esmaeli B
Leuk Lymphoma 2014 May;55(5):1013-7. Epub 2013 Aug 28 doi: 10.3109/10428194.2013.826353. PMID: 23879202
Second-line 90Yttrium-ibritumomab tiuxetan (Zevalin) in a patient with conjunctival mucosa-associated lymphoid tissue lymphoma refractory to rituximab.
Oellers P, Savar A, Samaniego F, Pro B, Esmaeli B
Ophthalmic Plast Reconstr Surg 2012 Nov-Dec;28(6):e145-6. doi: 10.1097/IOP.0b013e31824ab228. PMID: 22820440
Fornix and conjunctiva reconstruction by amniotic membrane in a patient with conjunctival mucosa-associated lymphoid tissue lymphoma.
Kobayashi A, Takahira M, Yamada A, Segawa Y, Tanahashi T, Shirao Y, Nonomura A
Jpn J Ophthalmol 2002 May-Jun;46(3):346-8. doi: 10.1016/s0021-5155(02)00476-8. PMID: 12063048
Bilateral conjunctival mucosa-associated lymphoid tissue lymphoma misdiagnosed as allergic conjunctivitis.
Lee DH, Sohn HW, Park SH, Kang YK
Cornea 2001 May;20(4):427-9. doi: 10.1097/00003226-200105000-00019. PMID: 11333335

Therapy

Conjunctival Lymphoma in a Patient on Fingolimod for Relapsing-Remitting Multiple Sclerosis.
Christopher KL, Elner VM, Demirci H
Ophthalmic Plast Reconstr Surg 2017 May/Jun;33(3):e73-e75. doi: 10.1097/IOP.0000000000000774. PMID: 27533512
Intralesional interferon-α for conjunctival mucosa-associated lymphoid tissue lymphoma: long-term results.
Blasi MA, Tiberti AC, Valente P, Laguardia M, Sammarco MG, Balestrazzi A, Larocca LM, Balestrazzi E
Ophthalmology 2012 Mar;119(3):494-500. Epub 2012 Jan 5 doi: 10.1016/j.ophtha.2011.09.008. PMID: 22226154
Intralesional interferon-α for the treatment of bilateral conjunctival mucosa-associated lymphoid tissue lymphoma.
Holds J, Buchanan A, Hanson R
Pediatr Blood Cancer 2012 Jul 15;59(1):176-8. Epub 2011 Jul 25 doi: 10.1002/pbc.23224. PMID: 21793177
Spectral-domain optical coherence tomography of conjunctival mucosa-associated lymphoid tissue lymphoma with presumed choroidal involvement.
Williams BK Jr, Tsui I, McCannel TA
Graefes Arch Clin Exp Ophthalmol 2010 Dec;248(12):1837-40. Epub 2010 Jun 8 doi: 10.1007/s00417-010-1427-5. PMID: 20532548Free PMC Article
Local chemotherapy with interferon-alpha for conjunctival mucosa-associated lymphoid tissue lymphoma: a preliminary report.
Blasi MA, Gherlinzoni F, Calvisi G, Sasso P, Tani M, Cellini M, Balestrazzi E
Ophthalmology 2001 Mar;108(3):559-62. doi: 10.1016/s0161-6420(00)00591-1. PMID: 11237911

Prognosis

Clinical value of magnetic resonance imaging and other baseline testing for conjunctival mucosa-associated lymphoid tissue lymphoma.
Nasser QJ, Pfeiffer ML, Romaguera J, Fowler N, Debnam JM, Samaniego F, El-Sawy T, McLaughlin P, Bakhoum MF, Esmaeli B
Leuk Lymphoma 2014 May;55(5):1013-7. Epub 2013 Aug 28 doi: 10.3109/10428194.2013.826353. PMID: 23879202
Intralesional interferon-α for conjunctival mucosa-associated lymphoid tissue lymphoma: long-term results.
Blasi MA, Tiberti AC, Valente P, Laguardia M, Sammarco MG, Balestrazzi A, Larocca LM, Balestrazzi E
Ophthalmology 2012 Mar;119(3):494-500. Epub 2012 Jan 5 doi: 10.1016/j.ophtha.2011.09.008. PMID: 22226154
Fornix and conjunctiva reconstruction by amniotic membrane in a patient with conjunctival mucosa-associated lymphoid tissue lymphoma.
Kobayashi A, Takahira M, Yamada A, Segawa Y, Tanahashi T, Shirao Y, Nonomura A
Jpn J Ophthalmol 2002 May-Jun;46(3):346-8. doi: 10.1016/s0021-5155(02)00476-8. PMID: 12063048

Clinical prediction guides

Feasibility of oral doxycycline as first-line therapy for conjunctival mucosa-associated lymphoid tissue lymphoma.
Choi SH, Yang MK, Kim TM, Choi HJ
Eye (Lond) 2024 Jan;38(1):82-88. Epub 2023 Jun 23 doi: 10.1038/s41433-023-02635-4. PMID: 37353510Free PMC Article
Intralesional interferon-α for the treatment of bilateral conjunctival mucosa-associated lymphoid tissue lymphoma.
Holds J, Buchanan A, Hanson R
Pediatr Blood Cancer 2012 Jul 15;59(1):176-8. Epub 2011 Jul 25 doi: 10.1002/pbc.23224. PMID: 21793177
Fornix and conjunctiva reconstruction by amniotic membrane in a patient with conjunctival mucosa-associated lymphoid tissue lymphoma.
Kobayashi A, Takahira M, Yamada A, Segawa Y, Tanahashi T, Shirao Y, Nonomura A
Jpn J Ophthalmol 2002 May-Jun;46(3):346-8. doi: 10.1016/s0021-5155(02)00476-8. PMID: 12063048

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