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Conjunctival cancer

MedGen UID:
56316
•Concept ID:
C0153628
•
Neoplastic Process
Synonyms: conjunctiva cancer; conjunctival cancer; Malignant Conjunctiva Neoplasm; malignant conjunctiva neoplasm; Malignant Conjunctiva Tumor; malignant conjunctiva tumor; malignant conjunctiva tumour; Malignant Conjunctival Neoplasm; malignant conjunctival neoplasm; Malignant Conjunctival Tumor; malignant conjunctival tumor; malignant conjunctival tumour; Malignant Neoplasm of Conjunctiva; malignant neoplasm of conjunctiva; malignant neoplasm of conjunctiva (primary); Malignant Neoplasm of the Conjunctiva; malignant neoplasm of the conjunctiva; Malignant tumor of conjunctiva; Malignant Tumor of Conjunctiva; malignant tumor of conjunctiva; Malignant Tumor of the Conjunctiva; malignant tumor of the conjunctiva; malignant tumour of conjunctiva; malignant tumour of the conjunctiva
SNOMED CT: Malignant tumor of conjunctiva (363463000)
 
Monarch Initiative: MONDO:0003454

Definition

A primary or metastatic malignant neoplasm that affects the conjunctiva. [from NCI]

Professional guidelines

PubMed

The Management of Ocular Surface Squamous Neoplasia (OSSN).
Yeoh CHY, Lee JJR, Lim BXH, Sundar G, Mehta JS, Chan ASY, Lim DKA, Watson SL, Honavar SG, Manotosh R, Lim CHL
Int J Mol Sci 2022 Dec 31;24(1) doi: 10.3390/ijms24010713. PMID: 36614155Free PMC Article
Ocular surface squamous neoplasia: management and outcomes.
Hӧllhumer R, Williams S, Michelow P
Eye (Lond) 2021 Jun;35(6):1562-1573. Epub 2021 Feb 9 doi: 10.1038/s41433-021-01422-3. PMID: 33564137Free PMC Article
Sebaceous carcinoma: evidence-based clinical practice guidelines.
Owen JL, Kibbi N, Worley B, Kelm RC, Wang JV, Barker CA, Behshad R, Bichakjian CK, Bolotin D, Bordeaux JS, Bradshaw SH, Cartee TV, Chandra S, Cho NL, Choi JN, Council ML, Demirci H, Eisen DB, Esmaeli B, Golda N, Huang CC, Ibrahim SF, Jiang SB, Kim J, Kuzel TM, Lai SY, Lawrence N, Lee EH, Leitenberger JJ, Maher IA, Mann MW, Minkis K, Mittal BB, Nehal KS, Neuhaus IM, Ozog DM, Petersen B, Rotemberg V, Samant S, Samie FH, Servaes S, Shields CL, Shin TM, Sobanko JF, Somani AK, Stebbins WG, Thomas JR, Thomas VD, Tse DT, Waldman AH, Wong MK, Xu YG, Yu SS, Zeitouni NC, Ramsay T, Reynolds KA, Poon E, Alam M
Lancet Oncol 2019 Dec;20(12):e699-e714. doi: 10.1016/S1470-2045(19)30673-4. PMID: 31797796

Recent clinical studies

Etiology

Immunodeficiency and Cancer in 3.5 Million People Living With Human Immunodeficiency Virus (HIV): The South African HIV Cancer Match Study.
Ruffieux Y, Muchengeti M, Egger M, Efthimiou O, Bartels L, Olago V, Davidović M, Dhokotera T, Bohlius J, Singh E, Rohner E
Clin Infect Dis 2021 Aug 2;73(3):e735-e744. doi: 10.1093/cid/ciab087. PMID: 33530095Free PMC Article
Conjunctival cancer in people living with HIV.
Muchengeti M, Bohlius J, Dhokotera TG
Curr Opin Infect Dis 2021 Feb 1;34(1):1-7. doi: 10.1097/QCO.0000000000000705. PMID: 33337616Free PMC Article
Epidemiological Analysis and Prognosis of Conjunctival Cancer in the Past Twenty Years: A Population-Based Retrospective Study Using SEER Data.
Diao Y, Li X, Huo Y, Li Z, Yang Q, Huang Y, Wang L
Biomed Res Int 2020;2020:1203938. Epub 2020 Jul 7 doi: 10.1155/2020/1203938. PMID: 32724792Free PMC Article
The epidemiology of conjunctival squamous cell carcinoma in Uganda.
Newton R, Ziegler J, Ateenyi-Agaba C, Bousarghin L, Casabonne D, Beral V, Mbidde E, Carpenter L, Reeves G, Parkin DM, Wabinga H, Mbulaiteye S, Jaffe H, Bourboulia D, Boshoff C, Touzé A, Coursaget P; Uganda Kaposi's Sarcoma Study Group
Br J Cancer 2002 Jul 29;87(3):301-8. doi: 10.1038/sj.bjc.6600451. PMID: 12177799Free PMC Article
Update: cancer risk in persons with HIV/AIDS in the era of combination antiretroviral therapy.
Grulich AE
AIDS Read 2000 Jun;10(6):341-6. PMID: 10881365

Diagnosis

Conjunctival cancer in people living with HIV.
Muchengeti M, Bohlius J, Dhokotera TG
Curr Opin Infect Dis 2021 Feb 1;34(1):1-7. doi: 10.1097/QCO.0000000000000705. PMID: 33337616Free PMC Article
Epidemiological Analysis and Prognosis of Conjunctival Cancer in the Past Twenty Years: A Population-Based Retrospective Study Using SEER Data.
Diao Y, Li X, Huo Y, Li Z, Yang Q, Huang Y, Wang L
Biomed Res Int 2020;2020:1203938. Epub 2020 Jul 7 doi: 10.1155/2020/1203938. PMID: 32724792Free PMC Article
Ocular surface squamous neoplasia in patients with HIV infection in sub-Saharan Africa.
Nagaiah G, Stotler C, Orem J, Mwanda WO, Remick SC
Curr Opin Oncol 2010 Sep;22(5):437-42. doi: 10.1097/CCO.0b013e32833cfcf9. PMID: 20639761Free PMC Article

Therapy

The epidemiology of conjunctival squamous cell carcinoma in Uganda.
Newton R, Ziegler J, Ateenyi-Agaba C, Bousarghin L, Casabonne D, Beral V, Mbidde E, Carpenter L, Reeves G, Parkin DM, Wabinga H, Mbulaiteye S, Jaffe H, Bourboulia D, Boshoff C, Touzé A, Coursaget P; Uganda Kaposi's Sarcoma Study Group
Br J Cancer 2002 Jul 29;87(3):301-8. doi: 10.1038/sj.bjc.6600451. PMID: 12177799Free PMC Article
Update: cancer risk in persons with HIV/AIDS in the era of combination antiretroviral therapy.
Grulich AE
AIDS Read 2000 Jun;10(6):341-6. PMID: 10881365

Prognosis

Immunodeficiency and Cancer in 3.5 Million People Living With Human Immunodeficiency Virus (HIV): The South African HIV Cancer Match Study.
Ruffieux Y, Muchengeti M, Egger M, Efthimiou O, Bartels L, Olago V, Davidović M, Dhokotera T, Bohlius J, Singh E, Rohner E
Clin Infect Dis 2021 Aug 2;73(3):e735-e744. doi: 10.1093/cid/ciab087. PMID: 33530095Free PMC Article
Epidemiological Analysis and Prognosis of Conjunctival Cancer in the Past Twenty Years: A Population-Based Retrospective Study Using SEER Data.
Diao Y, Li X, Huo Y, Li Z, Yang Q, Huang Y, Wang L
Biomed Res Int 2020;2020:1203938. Epub 2020 Jul 7 doi: 10.1155/2020/1203938. PMID: 32724792Free PMC Article
Ocular surface squamous neoplasia in patients with HIV infection in sub-Saharan Africa.
Nagaiah G, Stotler C, Orem J, Mwanda WO, Remick SC
Curr Opin Oncol 2010 Sep;22(5):437-42. doi: 10.1097/CCO.0b013e32833cfcf9. PMID: 20639761Free PMC Article
Postoperative adjuvant external-beam radiation therapy for cancers of the eyelid and conjunctiva.
Hsu A, Frank SJ, Ballo MT, Garden AS, Morrison WH, Rosenthal DI, Hatef E, Esmaeli B
Ophthalmic Plast Reconstr Surg 2008 Nov-Dec;24(6):444-9. doi: 10.1097/IOP.0b013e31818be098. PMID: 19033839

Clinical prediction guides

Epidemiological Analysis and Prognosis of Conjunctival Cancer in the Past Twenty Years: A Population-Based Retrospective Study Using SEER Data.
Diao Y, Li X, Huo Y, Li Z, Yang Q, Huang Y, Wang L
Biomed Res Int 2020;2020:1203938. Epub 2020 Jul 7 doi: 10.1155/2020/1203938. PMID: 32724792Free PMC Article
HPV infection and EGFR activation/alteration in HIV-infected East African patients with conjunctival carcinoma.
Yu JJ, Fu P, Pink JJ, Dawson D, Wasman J, Orem J, Mwanda WO, Zhu H, Liang X, Guo Y, Petros WP, Mitsuyasu RT, Wabinga H, Remick SC
PLoS One 2010 May 17;5(5):e10477. doi: 10.1371/journal.pone.0010477. PMID: 20498858Free PMC Article
Epidemiology of squamous cell conjunctival cancer.
Sun EC, Fears TR, Goedert JJ
Cancer Epidemiol Biomarkers Prev 1997 Feb;6(2):73-7. PMID: 9037556

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