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Ciliary body spindle cell melanoma

MedGen UID:
232367
•Concept ID:
C1333052
•
Neoplastic Process
Synonyms: Ciliary Body Spindle Cell Melanoma; ciliary body spindle cell melanoma; Spindle Cell Melanoma of Ciliary Body; spindle cell melanoma of ciliary body; Spindle Cell Melanoma of the Ciliary Body; spindle cell melanoma of the ciliary body
 
Monarch Initiative: MONDO:0003746

Definition

A melanoma that arises from the ciliary body. It is characterized by the presence of spindle-shaped melanocytes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCiliary body spindle cell melanoma

Professional guidelines

PubMed

HLA Class I and II genotype in uveal melanoma: relation to occurrence and prognosis.
Maat W, Haasnoot GW, Claas FH, Schalij-Delfos NE, Schreuder GM, Jager MJ
Invest Ophthalmol Vis Sci 2006 Jan;47(1):3-6. doi: 10.1167/iovs.05-1122. PMID: 16384937
Primary iris melanoma: diagnostic features and outcome of conservative surgical treatment.
Conway RM, Chua WC, Qureshi C, Billson FA
Br J Ophthalmol 2001 Jul;85(7):848-54. doi: 10.1136/bjo.85.7.848. PMID: 11423461Free PMC Article
Tumours of the anterior uvea. III. Oxytalan fibres in the differential diagnosis of leiomyoma and malignant melanoma of the iris.
Noor Sunba MS, Rahi AH, Garner A, Alexander RA, Morgan G
Br J Ophthalmol 1980 Nov;64(11):867-74. doi: 10.1136/bjo.64.11.867. PMID: 7426559Free PMC Article

Recent clinical studies

Etiology

Enucleation after Stereotactic Radiosurgery in Patients with Uveal Melanoma.
Zahorjanová P, Sekáč J, Babál P, Štubňa M
Cesk Slov Oftalmol 2020 Winter;76(1):46-51. doi: 10.31348/2020/6. PMID: 32917094
Uveal melanoma: An analysis of cellular features and comparison to monosomy 3 status.
Hamadeh F, Medina CA, Singh AD, Reynolds JP, Biscotti CV
Diagn Cytopathol 2016 May;44(5):377-83. Epub 2016 Feb 15 doi: 10.1002/dc.23450. PMID: 26876235
Iris melanoma.
Henderson E, Margo CE
Arch Pathol Lab Med 2008 Feb;132(2):268-72. doi: 10.5858/2008-132-268-IM. PMID: 18251588
Ring melanoma of the ciliary body: report on twenty-three patients.
Demirci H, Shields CL, Shields JA, Honavar SG, Eagle RC Jr
Retina 2002 Dec;22(6):698-706; quiz 852-3. doi: 10.1097/00006982-200212000-00003. PMID: 12476094
Uveal melanoma: location, size, cell type, and enucleation as risk factors in metastasis.
McLean IW, Foster WD, Zimmerman LE
Hum Pathol 1982 Feb;13(2):123-32. doi: 10.1016/s0046-8177(82)80116-0. PMID: 7076200

Diagnosis

Iris melanoma.
Henderson E, Margo CE
Arch Pathol Lab Med 2008 Feb;132(2):268-72. doi: 10.5858/2008-132-268-IM. PMID: 18251588
Ciliary body naevus.
Taban M, Sears JE, Singh AD
Eye (Lond) 2007 Dec;21(12):1528-30. Epub 2006 Oct 20 doi: 10.1038/sj.eye.6702622. PMID: 17041573
Cavitary choroidal melanoma.
Becerra EM, Saornil MA, Blanco G, Méndez MC, Muiños Y, Esteban MR
Can J Ophthalmol 2005 Oct;40(5):619-22. doi: 10.1016/S0008-4182(05)80057-2. PMID: 16391628
Transscleral resection of a ciliary body leiomyoma in a child: case report and review of the literature.
Richter MN, Bechrakis NE, Stoltenburg-Didinger G, Foerster MH
Graefes Arch Clin Exp Ophthalmol 2003 Nov;241(11):953-7. Epub 2003 Nov 1 doi: 10.1007/s00417-003-0766-x. PMID: 14595565
Uveal melanoma in China.
Kuo PK, Puliafito CA, Wang KM, Liu HS, Wu BF
Int Ophthalmol Clin 1982 Fall;22(3):57-71. doi: 10.1097/00004397-198202230-00007. PMID: 7107133

Therapy

No differences in the long-term prognosis of iris and choroidal melanomas when adjusting for tumor thickness and diameter.
Sabazade S, Herrspiegel C, Gill V, Stålhammar G
BMC Cancer 2021 Nov 24;21(1):1270. doi: 10.1186/s12885-021-09002-0. PMID: 34819035Free PMC Article
Enucleation after Stereotactic Radiosurgery in Patients with Uveal Melanoma.
Zahorjanová P, Sekáč J, Babál P, Štubňa M
Cesk Slov Oftalmol 2020 Winter;76(1):46-51. doi: 10.31348/2020/6. PMID: 32917094
Neoadjuvant intravitreal ranibizumab treatment in high-risk ocular melanoma patients: a two-stage single-centre phase II single-arm study.
Hussain RN, Heimann H, Damato B
Melanoma Res 2020 Feb;30(1):102-106. doi: 10.1097/CMR.0000000000000635. PMID: 31425478
Optic nerve invasion of uveal melanoma.
Lindegaard J, Isager P, Prause JU, Heegaard S
APMIS 2007 Jan;115(1):1-16. doi: 10.1111/j.1600-0463.2007.apm_527.x. PMID: 17223846
Trends in incidence of ocular malignant melanoma in Denmark 1943-1982.
Osterlind A
Int J Cancer 1987 Aug 15;40(2):161-4. doi: 10.1002/ijc.2910400206. PMID: 3610385

Prognosis

No differences in the long-term prognosis of iris and choroidal melanomas when adjusting for tumor thickness and diameter.
Sabazade S, Herrspiegel C, Gill V, Stålhammar G
BMC Cancer 2021 Nov 24;21(1):1270. doi: 10.1186/s12885-021-09002-0. PMID: 34819035Free PMC Article
Serum adiponectin, insulin resistance, and uveal melanoma: clinicopathological correlations.
Sevim DG, Kiratli H
Melanoma Res 2016 Apr;26(2):164-72. doi: 10.1097/CMR.0000000000000226. PMID: 26630661
Iris melanoma.
Henderson E, Margo CE
Arch Pathol Lab Med 2008 Feb;132(2):268-72. doi: 10.5858/2008-132-268-IM. PMID: 18251588
Pathological and prognostic features of uveal melanomas.
McLean IW, Saraiva VS, Burnier MN Jr
Can J Ophthalmol 2004 Jun;39(4):343-50. doi: 10.1016/s0008-4182(04)80004-8. PMID: 15327098
Transscleral resection of a ciliary body leiomyoma in a child: case report and review of the literature.
Richter MN, Bechrakis NE, Stoltenburg-Didinger G, Foerster MH
Graefes Arch Clin Exp Ophthalmol 2003 Nov;241(11):953-7. Epub 2003 Nov 1 doi: 10.1007/s00417-003-0766-x. PMID: 14595565

Clinical prediction guides

Serum adiponectin, insulin resistance, and uveal melanoma: clinicopathological correlations.
Sevim DG, Kiratli H
Melanoma Res 2016 Apr;26(2):164-72. doi: 10.1097/CMR.0000000000000226. PMID: 26630661
Pathological and prognostic features of uveal melanomas.
McLean IW, Saraiva VS, Burnier MN Jr
Can J Ophthalmol 2004 Jun;39(4):343-50. doi: 10.1016/s0008-4182(04)80004-8. PMID: 15327098
Ring melanoma of the ciliary body: report on twenty-three patients.
Demirci H, Shields CL, Shields JA, Honavar SG, Eagle RC Jr
Retina 2002 Dec;22(6):698-706; quiz 852-3. doi: 10.1097/00006982-200212000-00003. PMID: 12476094
Establishment and characterization of primary and metastatic uveal melanoma cell lines.
Luyten GP, Naus NC, Mooy CM, Hagemeijer A, Kan-Mitchell J, Van Drunen E, Vuzevski V, De Jong PT, Luider TM
Int J Cancer 1996 May 3;66(3):380-7. doi: 10.1002/(SICI)1097-0215(19960503)66:3<380::AID-IJC19>3.0.CO;2-F. PMID: 8621261
Uveal melanoma: location, size, cell type, and enucleation as risk factors in metastasis.
McLean IW, Foster WD, Zimmerman LE
Hum Pathol 1982 Feb;13(2):123-32. doi: 10.1016/s0046-8177(82)80116-0. PMID: 7076200

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