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Ciliary Body Spindle Cell Type A Melanoma

MedGen UID:
232368
•Concept ID:
C1333053
•
Neoplastic Process
Synonyms: Spindle Cell Type A Melanoma of Ciliary Body; Spindle Cell Type A Melanoma of the Ciliary Body

Definition

A ciliary body melanoma characterized by the presence of malignant spindle-shaped melanocytes with slender nuclei and no visible nucleoli. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCiliary Body Spindle Cell Type A Melanoma

Professional guidelines

PubMed

HLA Class I and II genotype in uveal melanoma: relation to occurrence and prognosis.
Maat W, Haasnoot GW, Claas FH, Schalij-Delfos NE, Schreuder GM, Jager MJ
Invest Ophthalmol Vis Sci 2006 Jan;47(1):3-6. doi: 10.1167/iovs.05-1122. PMID: 16384937
Tumours of the anterior uvea. III. Oxytalan fibres in the differential diagnosis of leiomyoma and malignant melanoma of the iris.
Noor Sunba MS, Rahi AH, Garner A, Alexander RA, Morgan G
Br J Ophthalmol 1980 Nov;64(11):867-74. doi: 10.1136/bjo.64.11.867. PMID: 7426559Free PMC Article

Recent clinical studies

Etiology

Enucleation after Stereotactic Radiosurgery in Patients with Uveal Melanoma.
Zahorjanová P, Sekáč J, Babál P, Štubňa M
Cesk Slov Oftalmol 2020 Winter;76(1):46-51. doi: 10.31348/2020/6. PMID: 32917094
Management and Outcome of Uveal Melanoma in a Single Tertiary Cancer Center in Jordan.
Zewar A, Nawaiseh I, Jaradat I, Khzouz J, Alrawashdeh K, Abdeen G, Mehyar M, Khurma S, Yousef YA
Turk Patoloji Derg 2016;32(3):186-92. doi: 10.5146/tjpath.2015.01357. PMID: 27562393
Uveal melanoma: An analysis of cellular features and comparison to monosomy 3 status.
Hamadeh F, Medina CA, Singh AD, Reynolds JP, Biscotti CV
Diagn Cytopathol 2016 May;44(5):377-83. Epub 2016 Feb 15 doi: 10.1002/dc.23450. PMID: 26876235
Ring melanoma of the ciliary body: report on twenty-three patients.
Demirci H, Shields CL, Shields JA, Honavar SG, Eagle RC Jr
Retina 2002 Dec;22(6):698-706; quiz 852-3. doi: 10.1097/00006982-200212000-00003. PMID: 12476094
Uveal melanoma: location, size, cell type, and enucleation as risk factors in metastasis.
McLean IW, Foster WD, Zimmerman LE
Hum Pathol 1982 Feb;13(2):123-32. doi: 10.1016/s0046-8177(82)80116-0. PMID: 7076200

Diagnosis

Management and Outcome of Uveal Melanoma in a Single Tertiary Cancer Center in Jordan.
Zewar A, Nawaiseh I, Jaradat I, Khzouz J, Alrawashdeh K, Abdeen G, Mehyar M, Khurma S, Yousef YA
Turk Patoloji Derg 2016;32(3):186-92. doi: 10.5146/tjpath.2015.01357. PMID: 27562393
Uveal melanoma: An analysis of cellular features and comparison to monosomy 3 status.
Hamadeh F, Medina CA, Singh AD, Reynolds JP, Biscotti CV
Diagn Cytopathol 2016 May;44(5):377-83. Epub 2016 Feb 15 doi: 10.1002/dc.23450. PMID: 26876235
Cavitary choroidal melanoma.
Becerra EM, Saornil MA, Blanco G, Méndez MC, Muiños Y, Esteban MR
Can J Ophthalmol 2005 Oct;40(5):619-22. doi: 10.1016/S0008-4182(05)80057-2. PMID: 16391628
Transscleral resection of a ciliary body leiomyoma in a child: case report and review of the literature.
Richter MN, Bechrakis NE, Stoltenburg-Didinger G, Foerster MH
Graefes Arch Clin Exp Ophthalmol 2003 Nov;241(11):953-7. Epub 2003 Nov 1 doi: 10.1007/s00417-003-0766-x. PMID: 14595565
Ring melanoma of the ciliary body: report on twenty-three patients.
Demirci H, Shields CL, Shields JA, Honavar SG, Eagle RC Jr
Retina 2002 Dec;22(6):698-706; quiz 852-3. doi: 10.1097/00006982-200212000-00003. PMID: 12476094

Therapy

Enucleation after Stereotactic Radiosurgery in Patients with Uveal Melanoma.
Zahorjanová P, Sekáč J, Babál P, Štubňa M
Cesk Slov Oftalmol 2020 Winter;76(1):46-51. doi: 10.31348/2020/6. PMID: 32917094
Optic nerve invasion of uveal melanoma.
Lindegaard J, Isager P, Prause JU, Heegaard S
APMIS 2007 Jan;115(1):1-16. doi: 10.1111/j.1600-0463.2007.apm_527.x. PMID: 17223846
Cell proliferation activity in posterior uveal melanoma after Ru-106 brachytherapy: an EORTC ocular oncology group study.
Pe'er J, Stefani FH, Seregard S, Kivela T, Lommatzsch P, Prause JU, Sobottka B, Damato B, Chowers I
Br J Ophthalmol 2001 Oct;85(10):1208-12. doi: 10.1136/bjo.85.10.1208. PMID: 11567966Free PMC Article
Establishment of IPC 227 cells as human xenografts in rabbits: a model of uveal melanoma.
Bonicel P, Michelot J, Bacin F, Papon J, Kemeny JL, Moins N, Morvan D, Madelmont JC
Melanoma Res 2000 Oct;10(5):445-50. doi: 10.1097/00008390-200010000-00006. PMID: 11095405
Trends in incidence of ocular malignant melanoma in Denmark 1943-1982.
Osterlind A
Int J Cancer 1987 Aug 15;40(2):161-4. doi: 10.1002/ijc.2910400206. PMID: 3610385

Prognosis

Clinicopathological Characteristics and Prognosis for Survival after Enucleation of Uveal Melanoma in Chinese Patients: Long-term Follow-up.
Yue H, Qian J, Yuan Y, Zhang R, Bi Y, Meng F, Xuan Y
Curr Eye Res 2017 May;42(5):759-765. Epub 2016 Dec 2 doi: 10.1080/02713683.2016.1245422. PMID: 27911584
Management and Outcome of Uveal Melanoma in a Single Tertiary Cancer Center in Jordan.
Zewar A, Nawaiseh I, Jaradat I, Khzouz J, Alrawashdeh K, Abdeen G, Mehyar M, Khurma S, Yousef YA
Turk Patoloji Derg 2016;32(3):186-92. doi: 10.5146/tjpath.2015.01357. PMID: 27562393
Serum adiponectin, insulin resistance, and uveal melanoma: clinicopathological correlations.
Sevim DG, Kiratli H
Melanoma Res 2016 Apr;26(2):164-72. doi: 10.1097/CMR.0000000000000226. PMID: 26630661
Pathological and prognostic features of uveal melanomas.
McLean IW, Saraiva VS, Burnier MN Jr
Can J Ophthalmol 2004 Jun;39(4):343-50. doi: 10.1016/s0008-4182(04)80004-8. PMID: 15327098
Transscleral resection of a ciliary body leiomyoma in a child: case report and review of the literature.
Richter MN, Bechrakis NE, Stoltenburg-Didinger G, Foerster MH
Graefes Arch Clin Exp Ophthalmol 2003 Nov;241(11):953-7. Epub 2003 Nov 1 doi: 10.1007/s00417-003-0766-x. PMID: 14595565

Clinical prediction guides

Management and Outcome of Uveal Melanoma in a Single Tertiary Cancer Center in Jordan.
Zewar A, Nawaiseh I, Jaradat I, Khzouz J, Alrawashdeh K, Abdeen G, Mehyar M, Khurma S, Yousef YA
Turk Patoloji Derg 2016;32(3):186-92. doi: 10.5146/tjpath.2015.01357. PMID: 27562393
Serum adiponectin, insulin resistance, and uveal melanoma: clinicopathological correlations.
Sevim DG, Kiratli H
Melanoma Res 2016 Apr;26(2):164-72. doi: 10.1097/CMR.0000000000000226. PMID: 26630661
Pathological and prognostic features of uveal melanomas.
McLean IW, Saraiva VS, Burnier MN Jr
Can J Ophthalmol 2004 Jun;39(4):343-50. doi: 10.1016/s0008-4182(04)80004-8. PMID: 15327098
Ring melanoma of the ciliary body: report on twenty-three patients.
Demirci H, Shields CL, Shields JA, Honavar SG, Eagle RC Jr
Retina 2002 Dec;22(6):698-706; quiz 852-3. doi: 10.1097/00006982-200212000-00003. PMID: 12476094
Uveal melanoma: location, size, cell type, and enucleation as risk factors in metastasis.
McLean IW, Foster WD, Zimmerman LE
Hum Pathol 1982 Feb;13(2):123-32. doi: 10.1016/s0046-8177(82)80116-0. PMID: 7076200

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