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Central nervous system hematopoietic neoplasm

MedGen UID:
234101
•Concept ID:
C1332882
•
Neoplastic Process
Synonyms: central nervous system haematopoietic and lymphoid system neoplasm; central nervous system haematopoietic neoplasms; central nervous system haematopoietic tumour; central nervous system hematologic cancer; central nervous system hematopoietic and lymphoid system neoplasm; Central Nervous System Hematopoietic Neoplasm; central nervous system hematopoietic neoplasm; Central Nervous System Hematopoietic Neoplasms; central nervous system hematopoietic neoplasms; Central Nervous System Hematopoietic Tumor; central nervous system hematopoietic tumor; CNS haematopoietic neoplasm; CNS haematopoietic tumour; CNS Hematopoietic Neoplasm; CNS hematopoietic neoplasm; CNS Hematopoietic Tumor; CNS hematopoietic tumor; haematopoietic and lymphoid system neoplasm of central nervous system; haematopoietic neoplasm of central nervous system; haematopoietic neoplasm of CNS; haematopoietic neoplasm of the central nervous system; haematopoietic neoplasm of the CNS; haematopoietic tumour of central nervous system; haematopoietic tumour of the central nervous system; hematopoietic and lymphoid system neoplasm of central nervous system; Hematopoietic Neoplasm of Central Nervous System; hematopoietic neoplasm of central nervous system; Hematopoietic Neoplasm of CNS; hematopoietic neoplasm of CNS; Hematopoietic Neoplasm of the Central Nervous System; hematopoietic neoplasm of the central nervous system; Hematopoietic Neoplasm of the CNS; hematopoietic neoplasm of the CNS; Hematopoietic Tumor of Central Nervous System; hematopoietic tumor of central nervous system; Hematopoietic Tumor of the Central Nervous System; hematopoietic tumor of the central nervous system; Lymphomas and Hemopoietic Neoplasms of CNS; lymphomas and hemopoietic neoplasms of CNS; Lymphomas and Hemopoietic Neoplasms of the CNS; lymphomas and hemopoietic neoplasms of the CNS
 
Monarch Initiative: MONDO:0003641

Definition

A neoplasm of hematopoietic origin that affects the brain, meninges, or spinal cord. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral nervous system hematopoietic neoplasm

Professional guidelines

PubMed

Primary central nervous system lymphoma.
Ferreri AJM, Calimeri T, Cwynarski K, Dietrich J, Grommes C, Hoang-Xuan K, Hu LS, Illerhaus G, Nayak L, Ponzoni M, Batchelor TT
Nat Rev Dis Primers 2023 Jun 15;9(1):29. doi: 10.1038/s41572-023-00439-0. PMID: 37322012Free PMC Article
Prevention and management of secondary central nervous system lymphoma.
Bobillo S, Khwaja J, Ferreri AJM, Cwynarski K
Haematologica 2023 Mar 1;108(3):673-689. doi: 10.3324/haematol.2022.281457. PMID: 36384246Free PMC Article
The treatment of Burkitt lymphoma in adults.
Crombie J, LaCasce A
Blood 2021 Feb 11;137(6):743-750. doi: 10.1182/blood.2019004099. PMID: 33171490

Recent clinical studies

Etiology

Prevention and management of secondary central nervous system lymphoma.
Bobillo S, Khwaja J, Ferreri AJM, Cwynarski K
Haematologica 2023 Mar 1;108(3):673-689. doi: 10.3324/haematol.2022.281457. PMID: 36384246Free PMC Article
Outcomes Associated With Thiotepa-Based Conditioning in Patients With Primary Central Nervous System Lymphoma After Autologous Hematopoietic Cell Transplant.
Scordo M, Wang TP, Ahn KW, Chen Y, Ahmed S, Awan FT, Beitinjaneh A, Chen A, Chow VA, Dholaria B, Epperla N, Farooq U, Ghosh N, Grover N, Hamad N, Hildebrandt GC, Holmberg L, Hong S, Inwards DJ, Jimenez-Jimenez A, Karmali R, Kenkre VP, Khimani F, Klyuchnikov E, Krem MM, Munshi PN, Nieto Y, Prestidge T, Ramakrishnan Geethakumari P, Rezvani AR, Riedell PA, Seo S, Shah NN, Solh M, Yared JA, Kharfan-Dabaja MA, Herrera A, Hamadani M, Sauter CS
JAMA Oncol 2021 Jul 1;7(7):993-1003. doi: 10.1001/jamaoncol.2021.1074. PMID: 33956047Free PMC Article
Cytokines in CAR T Cell-Associated Neurotoxicity.
Gust J, Ponce R, Liles WC, Garden GA, Turtle CJ
Front Immunol 2020;11:577027. Epub 2020 Dec 16 doi: 10.3389/fimmu.2020.577027. PMID: 33391257Free PMC Article
T cell acute lymphoblastic leukemia (T-ALL): New insights into the cellular origins and infiltration mechanisms common and unique among hematologic malignancies.
Vadillo E, Dorantes-Acosta E, Pelayo R, Schnoor M
Blood Rev 2018 Jan;32(1):36-51. Epub 2017 Aug 15 doi: 10.1016/j.blre.2017.08.006. PMID: 28830639
R-MPV followed by high-dose chemotherapy with TBC and autologous stem-cell transplant for newly diagnosed primary CNS lymphoma.
Omuro A, Correa DD, DeAngelis LM, Moskowitz CH, Matasar MJ, Kaley TJ, Gavrilovic IT, Nolan C, Pentsova E, Grommes CC, Panageas KS, Baser RE, Faivre G, Abrey LE, Sauter CS
Blood 2015 Feb 26;125(9):1403-10. Epub 2015 Jan 7 doi: 10.1182/blood-2014-10-604561. PMID: 25568347Free PMC Article

Diagnosis

Inpatient recognition and management of HLH.
Zoref-Lorenz A, Ellis M, Jordan MB
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):259-266. doi: 10.1182/hematology.2023000509. PMID: 38066887Free PMC Article
Primary central nervous system lymphoma.
Ferreri AJM, Calimeri T, Cwynarski K, Dietrich J, Grommes C, Hoang-Xuan K, Hu LS, Illerhaus G, Nayak L, Ponzoni M, Batchelor TT
Nat Rev Dis Primers 2023 Jun 15;9(1):29. doi: 10.1038/s41572-023-00439-0. PMID: 37322012Free PMC Article
How I Diagnose Rosai-Dorfman Disease.
Ravindran A, Rech KL
Am J Clin Pathol 2023 Jul 5;160(1):1-10. doi: 10.1093/ajcp/aqad047. PMID: 37167084
Acute Myeloid Leukemia, Version 3.2023, NCCN Clinical Practice Guidelines in Oncology.
Pollyea DA, Altman JK, Assi R, Bixby D, Fathi AT, Foran JM, Gojo I, Hall AC, Jonas BA, Kishtagari A, Lancet J, Maness L, Mangan J, Mannis G, Marcucci G, Mims A, Moriarty K, Mustafa Ali M, Neff J, Nejati R, Olin R, Percival ME, Perl A, Przespolewski A, Rao D, Ravandi F, Shallis R, Shami PJ, Stein E, Stone RM, Sweet K, Thota S, Uy G, Vachhani P, Cassara CJ, Freedman-Cass DA, Stehman K
J Natl Compr Canc Netw 2023 May;21(5):503-513. doi: 10.6004/jnccn.2023.0025. PMID: 37156478
Prevention and management of secondary central nervous system lymphoma.
Bobillo S, Khwaja J, Ferreri AJM, Cwynarski K
Haematologica 2023 Mar 1;108(3):673-689. doi: 10.3324/haematol.2022.281457. PMID: 36384246Free PMC Article

Therapy

Prevention and management of secondary central nervous system lymphoma.
Bobillo S, Khwaja J, Ferreri AJM, Cwynarski K
Haematologica 2023 Mar 1;108(3):673-689. doi: 10.3324/haematol.2022.281457. PMID: 36384246Free PMC Article
Evidence-based expert consensus on the management of primary central nervous system lymphoma in China.
Chen T, Liu Y, Wang Y, Chang Q, Wu J, Wang Z, Geng D, Yu JT, Li Y, Li XQ, Chen H, Zhuang D, Li J, Wang B, Jiang T, Lyu L, Song Y, Qiu X, Li W, Lin S, Zhang X, Lu D, Lei J, Chen Y, Mao Y
J Hematol Oncol 2022 Sep 29;15(1):136. doi: 10.1186/s13045-022-01356-7. PMID: 36176002Free PMC Article
Blastic plasmacytoid dendritic cell neoplasm (BPDCN): A promising future in the era of targeted therapeutics.
Adimora IJ, Wilson NR, Pemmaraju N
Cancer 2022 Aug 15;128(16):3019-3026. Epub 2022 Jun 21 doi: 10.1002/cncr.34345. PMID: 35726525
The treatment of Burkitt lymphoma in adults.
Crombie J, LaCasce A
Blood 2021 Feb 11;137(6):743-750. doi: 10.1182/blood.2019004099. PMID: 33171490
R-MPV followed by high-dose chemotherapy with TBC and autologous stem-cell transplant for newly diagnosed primary CNS lymphoma.
Omuro A, Correa DD, DeAngelis LM, Moskowitz CH, Matasar MJ, Kaley TJ, Gavrilovic IT, Nolan C, Pentsova E, Grommes CC, Panageas KS, Baser RE, Faivre G, Abrey LE, Sauter CS
Blood 2015 Feb 26;125(9):1403-10. Epub 2015 Jan 7 doi: 10.1182/blood-2014-10-604561. PMID: 25568347Free PMC Article

Prognosis

Leptomeningeal Metastasis: A Review of the Pathophysiology, Diagnostic Methodology, and Therapeutic Landscape.
Nguyen A, Nguyen A, Dada OT, Desai PD, Ricci JC, Godbole NB, Pierre K, Lucke-Wold B
Curr Oncol 2023 Jun 19;30(6):5906-5931. doi: 10.3390/curroncol30060442. PMID: 37366925Free PMC Article
Primary central nervous system lymphoma.
Ferreri AJM, Calimeri T, Cwynarski K, Dietrich J, Grommes C, Hoang-Xuan K, Hu LS, Illerhaus G, Nayak L, Ponzoni M, Batchelor TT
Nat Rev Dis Primers 2023 Jun 15;9(1):29. doi: 10.1038/s41572-023-00439-0. PMID: 37322012Free PMC Article
Blastic plasmacytoid dendritic cell neoplasm (BPDCN): A promising future in the era of targeted therapeutics.
Adimora IJ, Wilson NR, Pemmaraju N
Cancer 2022 Aug 15;128(16):3019-3026. Epub 2022 Jun 21 doi: 10.1002/cncr.34345. PMID: 35726525
The treatment of Burkitt lymphoma in adults.
Crombie J, LaCasce A
Blood 2021 Feb 11;137(6):743-750. doi: 10.1182/blood.2019004099. PMID: 33171490
T cell acute lymphoblastic leukemia (T-ALL): New insights into the cellular origins and infiltration mechanisms common and unique among hematologic malignancies.
Vadillo E, Dorantes-Acosta E, Pelayo R, Schnoor M
Blood Rev 2018 Jan;32(1):36-51. Epub 2017 Aug 15 doi: 10.1016/j.blre.2017.08.006. PMID: 28830639

Clinical prediction guides

Blastic plasmacytoid dendritic cell neoplasm: emerging developments and special considerations for 2023.
Pemmaraju N, Kantarjian H
Clin Adv Hematol Oncol 2023 May;21(5):257-264. PMID: 37145496
A Phase II Study of the Efficacy and Safety of Oral Selinexor in Recurrent Glioblastoma.
Lassman AB, Wen PY, van den Bent MJ, Plotkin SR, Walenkamp AME, Green AL, Li K, Walker CJ, Chang H, Tamir S, Henegar L, Shen Y, Alvarez MJ, Califano A, Landesman Y, Kauffman MG, Shacham S, Mau-Sørensen M
Clin Cancer Res 2022 Feb 1;28(3):452-460. Epub 2021 Nov 2 doi: 10.1158/1078-0432.CCR-21-2225. PMID: 34728525Free PMC Article
Outcomes Associated With Thiotepa-Based Conditioning in Patients With Primary Central Nervous System Lymphoma After Autologous Hematopoietic Cell Transplant.
Scordo M, Wang TP, Ahn KW, Chen Y, Ahmed S, Awan FT, Beitinjaneh A, Chen A, Chow VA, Dholaria B, Epperla N, Farooq U, Ghosh N, Grover N, Hamad N, Hildebrandt GC, Holmberg L, Hong S, Inwards DJ, Jimenez-Jimenez A, Karmali R, Kenkre VP, Khimani F, Klyuchnikov E, Krem MM, Munshi PN, Nieto Y, Prestidge T, Ramakrishnan Geethakumari P, Rezvani AR, Riedell PA, Seo S, Shah NN, Solh M, Yared JA, Kharfan-Dabaja MA, Herrera A, Hamadani M, Sauter CS
JAMA Oncol 2021 Jul 1;7(7):993-1003. doi: 10.1001/jamaoncol.2021.1074. PMID: 33956047Free PMC Article
Central nervous system emergencies in haematological malignancies.
de la Fuente MI, Alderuccio JP, Lossos IS
Br J Haematol 2020 Jun;189(6):1028-1037. Epub 2019 Sep 4 doi: 10.1111/bjh.16184. PMID: 31483060
R-MPV followed by high-dose chemotherapy with TBC and autologous stem-cell transplant for newly diagnosed primary CNS lymphoma.
Omuro A, Correa DD, DeAngelis LM, Moskowitz CH, Matasar MJ, Kaley TJ, Gavrilovic IT, Nolan C, Pentsova E, Grommes CC, Panageas KS, Baser RE, Faivre G, Abrey LE, Sauter CS
Blood 2015 Feb 26;125(9):1403-10. Epub 2015 Jan 7 doi: 10.1182/blood-2014-10-604561. PMID: 25568347Free PMC Article

Recent systematic reviews

Autologous hematopoietic cell transplantation versus whole-brain radiotherapy consolidation in primary central nervous system lymphoma: A systematic review and meta-analysis.
Epperla N, Reljic T, Chowdhury SM, Ferreri AJM, Kumar A, Hamadani M
Hematol Oncol 2023 Feb;41(1):88-96. Epub 2022 Oct 6 doi: 10.1002/hon.3083. PMID: 36192141
A systematic review of craniospinal irradiation for leptomeningeal disease: past, present, and future.
Maillie L, Salgado LR, Lazarev S
Clin Transl Oncol 2021 Oct;23(10):2109-2119. Epub 2021 Apr 21 doi: 10.1007/s12094-021-02615-8. PMID: 33881707
Aspects of vincristine-induced neuropathy in hematologic malignancies: a systematic review.
Madsen ML, Due H, Ejskjær N, Jensen P, Madsen J, Dybkær K
Cancer Chemother Pharmacol 2019 Sep;84(3):471-485. Epub 2019 Jun 18 doi: 10.1007/s00280-019-03884-5. PMID: 31214762Free PMC Article
Effectiveness and safety of thiotepa as conditioning treatment prior to stem cell transplant in patients with central nervous system lymphoma.
Kokolo MB, Fergusson D, O'Neill J, Tay J, Tinmouth AT, Stewart D, Bredeson C
Leuk Lymphoma 2014 Dec;55(12):2712-20. Epub 2014 Mar 26 doi: 10.3109/10428194.2014.889825. PMID: 24491026
Management of recurrent medulloblastoma in adult patients: a systematic review and recommendations.
Kostaras X, Easaw JC
J Neurooncol 2013 Oct;115(1):1-8. Epub 2013 Jul 23 doi: 10.1007/s11060-013-1206-3. PMID: 23877361

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