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Pulmonary sulcus neoplasm

MedGen UID:
277550
•Concept ID:
C1335574
•
Neoplastic Process
Synonyms: Pulmonary Sulcus Neoplasm; pulmonary sulcus neoplasm; Pulmonary Sulcus Tumor; pulmonary sulcus tumor; pulmonary sulcus tumour
 
Monarch Initiative: MONDO:0024813

Definition

A neoplasm originating from the apical lung. Most superior sulcus neoplasms are bronchogenic carcinomas. This tumor may be associated with Pancoast syndrome. It is also known as Pancoast tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPulmonary sulcus neoplasm

Professional guidelines

PubMed

Management of Lung Cancer Invading the Superior Sulcus.
Kratz JR, Woodard G, Jablons DM
Thorac Surg Clin 2017 May;27(2):149-157. doi: 10.1016/j.thorsurg.2017.01.008. PMID: 28363369
Surgical management of locally advanced lung cancer.
Yokoi K, Taniguchi T, Usami N, Kawaguchi K, Fukui T, Ishiguro F
Gen Thorac Cardiovasc Surg 2014 Sep;62(9):522-30. Epub 2014 May 29 doi: 10.1007/s11748-014-0425-7. PMID: 24871783
Management of Pancoast tumours.
Rusch VW
Lancet Oncol 2006 Dec;7(12):997-1005. doi: 10.1016/S1470-2045(06)70974-3. PMID: 17138221

Recent clinical studies

Etiology

Superior sulcus non-small cell lung cancers (Pancoast tumors): Current outcomes after multidisciplinary management.
McLaughlin K, Tan KS, Dycoco J, Chen MF, Chaft JE, Mankuzhy NP, Rimner A, Aly RG, Fanaroff RE, Travis WD, Bilsky M, Bains M, Downey R, Huang J, Isbell JM, Molena D, Park BJ, Jones DR, Rusch VW
J Thorac Cardiovasc Surg 2023 Dec;166(6):1477-1487.e8. Epub 2023 Aug 22 doi: 10.1016/j.jtcvs.2023.08.023. PMID: 37611845Free PMC Article
Induction chemoradiation and surgical resection for superior sulcus non-small-cell lung carcinomas: long-term results of Southwest Oncology Group Trial 9416 (Intergroup Trial 0160).
Rusch VW, Giroux DJ, Kraut MJ, Crowley J, Hazuka M, Winton T, Johnson DH, Shulman L, Shepherd F, Deschamps C, Livingston RB, Gandara D
J Clin Oncol 2007 Jan 20;25(3):313-8. doi: 10.1200/JCO.2006.08.2826. PMID: 17235046
Surgery: therapeutic indications.
Van Schil PE
Cancer Radiother 2007 Jan-Feb;11(1-2):47-52. Epub 2006 Jul 11 doi: 10.1016/j.canrad.2006.06.001. PMID: 16837227
Surgical treatment of chest wall tumors.
Incarbone M, Pastorino U
World J Surg 2001 Feb;25(2):218-30. doi: 10.1007/s002680020022. PMID: 11338025
Carcinoma in the superior pulmonary sulcus.
Paulson DL
Ann Thorac Surg 1979 Jul;28(1):3-4. doi: 10.1016/s0003-4975(10)63381-4. PMID: 454041

Diagnosis

Pancoast tumour: current therapeutic options.
Palumbo VD, Fazzotta S, Fatica F, D'Orazio B, Caronia FP, Cajozzo M, Damiano G, Maffongelli A, Cudia BM, Messina M, Lo Monte AI
Clin Ter 2019 Jul-Aug;170(4):e291-e294. doi: 10.7417/CT.2019.2150. PMID: 31304518
Diagnosing and treating pancoast tumors.
Zarogoulidis K, Porpodis K, Domvri K, Eleftheriadou E, Ioannidou D, Zarogoulidis P
Expert Rev Respir Med 2016 Dec;10(12):1255-1258. Epub 2016 Oct 27 doi: 10.1080/17476348.2017.1246964. PMID: 27786592
Differential diagnosis of cervical radiculopathy and superior pulmonary sulcus tumor.
Gu R, Kang MY, Gao ZL, Zhao JW, Wang JC
Chin Med J (Engl) 2012 Aug;125(15):2755-7. PMID: 22931987
MRI in lung cancer: a pictorial essay.
Hochhegger B, Marchiori E, Sedlaczek O, Irion K, Heussel CP, Ley S, Ley-Zaporozhan J, Soares Souza A Jr, Kauczor HU
Br J Radiol 2011 Jul;84(1003):661-8. doi: 10.1259/bjr/24661484. PMID: 21697415Free PMC Article
Superior sulcus tumors.
Wright CD, Mathisen DJ
Curr Treat Options Oncol 2001 Feb;2(1):43-9. doi: 10.1007/s11864-001-0015-7. PMID: 12057139

Therapy

Superior sulcus non-small cell lung cancers (Pancoast tumors): Current outcomes after multidisciplinary management.
McLaughlin K, Tan KS, Dycoco J, Chen MF, Chaft JE, Mankuzhy NP, Rimner A, Aly RG, Fanaroff RE, Travis WD, Bilsky M, Bains M, Downey R, Huang J, Isbell JM, Molena D, Park BJ, Jones DR, Rusch VW
J Thorac Cardiovasc Surg 2023 Dec;166(6):1477-1487.e8. Epub 2023 Aug 22 doi: 10.1016/j.jtcvs.2023.08.023. PMID: 37611845Free PMC Article
Pancoast tumor: a modern perspective on an old problem.
Glassman LR, Hyman K
Curr Opin Pulm Med 2013 Jul;19(4):340-3. doi: 10.1097/MCP.0b013e3283621b31. PMID: 23702478
Induction chemoradiation and surgical resection for superior sulcus non-small-cell lung carcinomas: long-term results of Southwest Oncology Group Trial 9416 (Intergroup Trial 0160).
Rusch VW, Giroux DJ, Kraut MJ, Crowley J, Hazuka M, Winton T, Johnson DH, Shulman L, Shepherd F, Deschamps C, Livingston RB, Gandara D
J Clin Oncol 2007 Jan 20;25(3):313-8. doi: 10.1200/JCO.2006.08.2826. PMID: 17235046
Surgery: therapeutic indications.
Van Schil PE
Cancer Radiother 2007 Jan-Feb;11(1-2):47-52. Epub 2006 Jul 11 doi: 10.1016/j.canrad.2006.06.001. PMID: 16837227
Superior sulcus tumors.
Wright CD, Mathisen DJ
Curr Treat Options Oncol 2001 Feb;2(1):43-9. doi: 10.1007/s11864-001-0015-7. PMID: 12057139

Prognosis

Surgical management of locally advanced lung cancer.
Yokoi K, Taniguchi T, Usami N, Kawaguchi K, Fukui T, Ishiguro F
Gen Thorac Cardiovasc Surg 2014 Sep;62(9):522-30. Epub 2014 May 29 doi: 10.1007/s11748-014-0425-7. PMID: 24871783
Induction chemoradiation and surgical resection for superior sulcus non-small-cell lung carcinomas: long-term results of Southwest Oncology Group Trial 9416 (Intergroup Trial 0160).
Rusch VW, Giroux DJ, Kraut MJ, Crowley J, Hazuka M, Winton T, Johnson DH, Shulman L, Shepherd F, Deschamps C, Livingston RB, Gandara D
J Clin Oncol 2007 Jan 20;25(3):313-8. doi: 10.1200/JCO.2006.08.2826. PMID: 17235046
Surgery: therapeutic indications.
Van Schil PE
Cancer Radiother 2007 Jan-Feb;11(1-2):47-52. Epub 2006 Jul 11 doi: 10.1016/j.canrad.2006.06.001. PMID: 16837227
Pancoast tumors of the lung.
Jones DR, Detterbeck FC
Curr Opin Pulm Med 1998 Jul;4(4):191-7. doi: 10.1097/00063198-199807000-00001. PMID: 10813231
Superior pulmonary sulcus tumors and Pancoast's syndrome.
Arcasoy SM, Jett JR
N Engl J Med 1997 Nov 6;337(19):1370-6. doi: 10.1056/NEJM199711063371907. PMID: 9358132

Clinical prediction guides

Trimodality Treatment of Superior Sulcus Non-Small Cell Lung Cancer: An Institutional Series of 47 Consecutive Patients.
Rzyman W, Łazar-Poniatowska M, Dziedzic R, Marjański T, Łapiński M, Dziadziuszko R
Curr Oncol 2023 Apr 27;30(5):4551-4562. doi: 10.3390/curroncol30050344. PMID: 37232802Free PMC Article
Influence of anterior tumor location on survival after resection of lung cancer invading the thoracic inlet (Pancoast tumors).
Tsitsias T, Yasufuku K, Pierre A, Leighl N, Cho J, Waddell TK, Darling G, Cypel M, Donahoe L, Yeung J, Keshavjee S, de Perrot M
J Thorac Cardiovasc Surg 2023 May;165(5):1710-1719.e3. Epub 2022 Nov 2 doi: 10.1016/j.jtcvs.2022.10.033. PMID: 36481062
Clinical Prediction of Pathologic Complete Response in Superior Sulcus Non-Small Cell Lung Cancer.
Antonoff MB, Hofstetter WL, Correa AM, Bell JM, Sepesi B, Rice DC, Vaporciyan AA, Walsh GL, Mehran RJ, Swisher SG, Meyers BF
Ann Thorac Surg 2016 Jan;101(1):211-7. Epub 2015 Aug 14 doi: 10.1016/j.athoracsur.2015.06.019. PMID: 26279367
Treatment outcomes in 23 thoracic primitive neuroectodermal tumours: a retrospective study.
Sirivella S, Gielchinsky I
Interact Cardiovasc Thorac Surg 2013 Aug;17(2):273-9. Epub 2013 May 2 doi: 10.1093/icvts/ivt161. PMID: 23639759Free PMC Article
Superior sulcus tumors with vertebral body involvement: a multimodality approach.
Bolton WD, Rice DC, Goodyear A, Correa AM, Erasmus J, Hofstetter W, Komaki R, Mehran R, Pisters K, Roth JA, Swisher SG, Vaporciyan AA, Walsh GL, Weaver J, Rhines L
J Thorac Cardiovasc Surg 2009 Jun;137(6):1379-87. doi: 10.1016/j.jtcvs.2009.01.015. PMID: 19464452

Recent systematic reviews

En Bloc Resection of Pulmonary Sulcus Non-small Cell Lung Cancer Invading the Spine: A Systematic Literature Review and Pooled Data Analysis.
Collaud S, Fadel E, Schirren J, Yokomise H, Bolukbas S, Dartevelle P, Keshavjee S, Waddell TK, de Perrot M
Ann Surg 2015 Jul;262(1):184-8. doi: 10.1097/SLA.0000000000000797. PMID: 25072427
Management of locally advanced pancoast (superior sulcus) tumors with spine involvement.
Setzer M, Robinson LA, Vrionis FD
Cancer Control 2014 Apr;21(2):158-67. doi: 10.1177/107327481402100209. PMID: 24667403

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