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Stage III Pharyngeal Cancer

MedGen UID:
277994
•Concept ID:
C1378109
•
Neoplastic Process
Synonyms: Pharyngeal Cancer Stage III; Stage III Carcinoma of Pharynx; Stage III Carcinoma of the Pharynx; Stage III Pharyngeal Carcinoma; Stage III Pharynx Carcinoma

Definition

Stage III carcinoma of the pharynx according to the American Joint Committee on Cancer, 6th, 7th, and 8th editions. [from NCI]

Professional guidelines

PubMed

Surgical Treatment for Advanced Oropharyngeal Cancer: A Narrative Review.
Maniaci A, Hao SP, Cancemi F, Giardini D, Checcoli E, Soprani F, Iannella G, Vicini C, Cocuzza S, La Mantia I, Fakhry N, De Vito A
Medicina (Kaunas) 2023 Feb 7;59(2) doi: 10.3390/medicina59020304. PMID: 36837506Free PMC Article
Radiation Treatment Deintensification for HPV-Associated Oropharyngeal Cancer.
Dagan R, Galloway TJ
Semin Radiat Oncol 2021 Oct;31(4):324-331. doi: 10.1016/j.semradonc.2021.02.010. PMID: 34455987
Multimodality Treatment of Early-Stage Tonsil Cancer.
Roden DF, Schreiber D, Givi B
Otolaryngol Head Neck Surg 2017 Jul;157(1):62-68. Epub 2017 Mar 7 doi: 10.1177/0194599817696290. PMID: 28669307

Recent clinical studies

Therapy

Hyperfractionation compared with standard fractionation in intensity-modulated radiotherapy for patients with locally advanced recurrent nasopharyngeal carcinoma: a multicentre, randomised, open-label, phase 3 trial.
You R, Liu YP, Xie YL, Lin C, Duan CY, Chen DP, Pan Y, Qi B, Zou X, Guo L, Cao JY, Zhang YN, Wang ZQ, Liu YL, Ouyang YF, Wen K, Yang Q, Xie RQ, Li HF, Duan XT, Ding X, Peng L, Chen SY, Liang JL, Feng ZK, Xia TL, Xie RL, Jiang R, Gu CM, Liu RZ, Sun R, Yang X, Liu LZ, Ling L, Liu Q, Ng WT, Hua YJ, Huang PY, Chen MY
Lancet 2023 Mar 18;401(10380):917-927. Epub 2023 Feb 23 doi: 10.1016/S0140-6736(23)00269-6. PMID: 36842439
Effect of Radiotherapy Alone vs Radiotherapy With Concurrent Chemoradiotherapy on Survival Without Disease Relapse in Patients With Low-risk Nasopharyngeal Carcinoma: A Randomized Clinical Trial.
Tang LL, Guo R, Zhang N, Deng B, Chen L, Cheng ZB, Huang J, Hu WH, Huang SH, Luo WJ, Liang JH, Zheng YM, Zhang F, Mao YP, Li WF, Zhou GQ, Liu X, Chen YP, Xu C, Lin L, Liu Q, Du XJ, Zhang Y, Sun Y, Ma J
JAMA 2022 Aug 23;328(8):728-736. doi: 10.1001/jama.2022.13997. PMID: 35997729Free PMC Article
Effect of Induction Chemotherapy With Paclitaxel, Cisplatin, and Capecitabine vs Cisplatin and Fluorouracil on Failure-Free Survival for Patients With Stage IVA to IVB Nasopharyngeal Carcinoma: A Multicenter Phase 3 Randomized Clinical Trial.
Li WZ, Lv X, Hu D, Lv SH, Liu GY, Liang H, Ye YF, Yang W, Zhang HX, Yuan TZ, Wang DS, Lu N, Ke LR, Tang WB, Tong LH, Chen ZJ, Liu T, Cao KJ, Mo HY, Guo L, Zhao C, Chen MY, Chen QY, Huang PY, Sun R, Qiu F, Luo DH, Wang L, Hua YJ, Tang LQ, Qian CN, Mai HQ, Guo X, Xiang YQ, Xia WX
JAMA Oncol 2022 May 1;8(5):706-714. doi: 10.1001/jamaoncol.2022.0122. PMID: 35323856Free PMC Article
Metronomic capecitabine as adjuvant therapy in locoregionally advanced nasopharyngeal carcinoma: a multicentre, open-label, parallel-group, randomised, controlled, phase 3 trial.
Chen YP, Liu X, Zhou Q, Yang KY, Jin F, Zhu XD, Shi M, Hu GQ, Hu WH, Sun Y, Wu HF, Wu H, Lin Q, Wang H, Tian Y, Zhang N, Wang XC, Shen LF, Liu ZZ, Huang J, Luo XL, Li L, Zang J, Mei Q, Zheng BM, Yue D, Xu J, Wu SG, Shi YX, Mao YP, Chen L, Li WF, Zhou GQ, Sun R, Guo R, Zhang Y, Xu C, Lv JW, Guo Y, Feng HX, Tang LL, Xie FY, Sun Y, Ma J
Lancet 2021 Jul 24;398(10297):303-313. Epub 2021 Jun 7 doi: 10.1016/S0140-6736(21)01123-5. PMID: 34111416
Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma.
Denis F, Garaud P, Bardet E, Alfonsi M, Sire C, Germain T, Bergerot P, Rhein B, Tortochaux J, Calais G
J Clin Oncol 2004 Jan 1;22(1):69-76. Epub 2003 Dec 2 doi: 10.1200/JCO.2004.08.021. PMID: 14657228

Prognosis

Improved survival prediction for oropharyngeal cancer beyond TNMv8.
Price JM, West CM, Mistry HB, Betts G, Bishop P, Kennedy J, Dixon L, Homer JJ, Garcez KP, Lee LW, McPartlin A, Sykes AJ, Thomson DJ
Oral Oncol 2021 Apr;115:105140. Epub 2021 Feb 3 doi: 10.1016/j.oraloncology.2020.105140. PMID: 33548862
Reduced-Dose Radiation Therapy for HPV-Associated Oropharyngeal Carcinoma (NRG Oncology HN002).
Yom SS, Torres-Saavedra P, Caudell JJ, Waldron JN, Gillison ML, Xia P, Truong MT, Kong C, Jordan R, Subramaniam RM, Yao M, Chung CH, Geiger JL, Chan JW, O'Sullivan B, Blakaj DM, Mell LK, Thorstad WL, Jones CU, Banerjee RN, Lominska C, Le QT
J Clin Oncol 2021 Mar 20;39(9):956-965. Epub 2021 Jan 28 doi: 10.1200/JCO.20.03128. PMID: 33507809Free PMC Article
Multimodality Treatment of Early-Stage Tonsil Cancer.
Roden DF, Schreiber D, Givi B
Otolaryngol Head Neck Surg 2017 Jul;157(1):62-68. Epub 2017 Mar 7 doi: 10.1177/0194599817696290. PMID: 28669307
Emerging treatment options for nasopharyngeal carcinoma.
Zhang L, Chen QY, Liu H, Tang LQ, Mai HQ
Drug Des Devel Ther 2013;7:37-52. Epub 2013 Feb 1 doi: 10.2147/DDDT.S30753. PMID: 23403548Free PMC Article
Chemotherapy in advanced nasopharyngeal cancer.
Ali H, al-Sarraf M
Oncology (Williston Park) 2000 Aug;14(8):1223-30; discussion 1232-7, 1239-42. PMID: 10989829

Clinical prediction guides

Induction Chemotherapy Followed by Radiotherapy vs Chemoradiotherapy in Nasopharyngeal Carcinoma: A Randomized Clinical Trial.
Dai J, Zhang B, Su Y, Pan Y, Ye Z, Cai R, Qin G, Kong X, Mo Y, Zhang R, Liu Z, Xie Y, Ruan X, Jiang W
JAMA Oncol 2024 Apr 1;10(4):456-463. doi: 10.1001/jamaoncol.2023.6552. PMID: 38329737Free PMC Article
Effect of Radiotherapy Alone vs Radiotherapy With Concurrent Chemoradiotherapy on Survival Without Disease Relapse in Patients With Low-risk Nasopharyngeal Carcinoma: A Randomized Clinical Trial.
Tang LL, Guo R, Zhang N, Deng B, Chen L, Cheng ZB, Huang J, Hu WH, Huang SH, Luo WJ, Liang JH, Zheng YM, Zhang F, Mao YP, Li WF, Zhou GQ, Liu X, Chen YP, Xu C, Lin L, Liu Q, Du XJ, Zhang Y, Sun Y, Ma J
JAMA 2022 Aug 23;328(8):728-736. doi: 10.1001/jama.2022.13997. PMID: 35997729Free PMC Article
Elective upper-neck versus whole-neck irradiation of the uninvolved neck in patients with nasopharyngeal carcinoma: an open-label, non-inferiority, multicentre, randomised phase 3 trial.
Tang LL, Huang CL, Zhang N, Jiang W, Wu YS, Huang SH, Mao YP, Liu Q, Li JB, Liang SQ, Qin GJ, Hu WH, Sun Y, Xie FY, Chen L, Zhou GQ, Ma J
Lancet Oncol 2022 Apr;23(4):479-490. Epub 2022 Feb 28 doi: 10.1016/S1470-2045(22)00058-4. PMID: 35240053
Retrospective analysis of massive epistaxis and pseudoaneurysms in nasopharyngeal carcinoma after radiotherapy.
Zeng L, Wan W, Luo Q, Jiang H, Ye J
Eur Arch Otorhinolaryngol 2022 Jun;279(6):2973-2980. Epub 2021 Oct 8 doi: 10.1007/s00405-021-07111-x. PMID: 34623497
Reduced-Dose Radiation Therapy for HPV-Associated Oropharyngeal Carcinoma (NRG Oncology HN002).
Yom SS, Torres-Saavedra P, Caudell JJ, Waldron JN, Gillison ML, Xia P, Truong MT, Kong C, Jordan R, Subramaniam RM, Yao M, Chung CH, Geiger JL, Chan JW, O'Sullivan B, Blakaj DM, Mell LK, Thorstad WL, Jones CU, Banerjee RN, Lominska C, Le QT
J Clin Oncol 2021 Mar 20;39(9):956-965. Epub 2021 Jan 28 doi: 10.1200/JCO.20.03128. PMID: 33507809Free PMC Article

Recent systematic reviews

Characteristics of human papillomavirus infection among oropharyngeal cancer patients: A systematic review and meta-analysis.
Cui M, Cheng J, Cheng H, Zhao M, Zhou D, Zhang M, Jia J, Luo L
Arch Oral Biol 2024 Jan;157:105830. Epub 2023 Oct 31 doi: 10.1016/j.archoralbio.2023.105830. PMID: 37924712
Early-onset juvenile nasopharyngeal angiofibroma (JNA): a systematic review.
Newman M, Nguyen TBV, McHugh T, Reddy K, Sommer DD
J Otolaryngol Head Neck Surg 2023 Dec 19;52(1):85. doi: 10.1186/s40463-023-00687-w. PMID: 38115030Free PMC Article
Survival-related epithelial-mesenchymal transition proteins in oropharyngeal squamous cell carcinoma: A systematic review and meta-analysis.
Maria de França G, Andrade ACM, Felix FA, da Silva WR, Almeida DRMF, Leite RB, Galvão HC, Miguel MCDC
Arch Oral Biol 2021 Nov;131:105267. Epub 2021 Sep 20 doi: 10.1016/j.archoralbio.2021.105267. PMID: 34592489
Survival benefit of induction chemotherapy in treatment for stage III or IV locally advanced nasopharyngeal carcinoma - An updated meta-analysis and systematic review.
Hu T, Fang L, Shi L, Wang W, Huang Y
Am J Otolaryngol 2021 Sep-Oct;42(5):102973. Epub 2021 Mar 19 doi: 10.1016/j.amjoto.2021.102973. PMID: 33812206
Minimally invasive surgery versus radiotherapy/chemoradiotherapy for small-volume primary oropharyngeal carcinoma.
Howard J, Masterson L, Dwivedi RC, Riffat F, Benson R, Jefferies S, Jani P, Tysome JR, Nutting C
Cochrane Database Syst Rev 2016 Dec 11;12(12):CD010963. doi: 10.1002/14651858.CD010963.pub2. PMID: 27943254Free PMC Article

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