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Central Nervous System Signs and Symptoms

MedGen UID:
416166
•Concept ID:
C2828177
•
Sign or Symptom

Definition

Signs and symptoms associated with disturbances within the central nervous system, which includes the brain, spinal cord and meninges. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral Nervous System Signs and Symptoms

Professional guidelines

PubMed

The Movement Disorder Society Criteria for the Diagnosis of Multiple System Atrophy.
Wenning GK, Stankovic I, Vignatelli L, Fanciulli A, Calandra-Buonaura G, Seppi K, Palma JA, Meissner WG, Krismer F, Berg D, Cortelli P, Freeman R, Halliday G, Höglinger G, Lang A, Ling H, Litvan I, Low P, Miki Y, Panicker J, Pellecchia MT, Quinn N, Sakakibara R, Stamelou M, Tolosa E, Tsuji S, Warner T, Poewe W, Kaufmann H
Mov Disord 2022 Jun;37(6):1131-1148. Epub 2022 Apr 21 doi: 10.1002/mds.29005. PMID: 35445419Free PMC Article
Diagnosis and Treatment of Multiple Sclerosis: A Review.
McGinley MP, Goldschmidt CH, Rae-Grant AD
JAMA 2021 Feb 23;325(8):765-779. doi: 10.1001/jama.2020.26858. PMID: 33620411
Clinical Practice Guideline: Benign Paroxysmal Positional Vertigo (Update).
Bhattacharyya N, Gubbels SP, Schwartz SR, Edlow JA, El-Kashlan H, Fife T, Holmberg JM, Mahoney K, Hollingsworth DB, Roberts R, Seidman MD, Steiner RW, Do BT, Voelker CC, Waguespack RW, Corrigan MD
Otolaryngol Head Neck Surg 2017 Mar;156(3_suppl):S1-S47. doi: 10.1177/0194599816689667. PMID: 28248609

Recent clinical studies

Etiology

Muscle Cramping During Exercise: Causes, Solutions, and Questions Remaining.
Maughan RJ, Shirreffs SM
Sports Med 2019 Dec;49(Suppl 2):115-124. doi: 10.1007/s40279-019-01162-1. PMID: 31696455Free PMC Article
Inflammation in the pathophysiology of neuropathic pain.
Sommer C, Leinders M, Üçeyler N
Pain 2018 Mar;159(3):595-602. doi: 10.1097/j.pain.0000000000001122. PMID: 29447138
Symptoms of menopause - global prevalence, physiology and implications.
Monteleone P, Mascagni G, Giannini A, Genazzani AR, Simoncini T
Nat Rev Endocrinol 2018 Apr;14(4):199-215. Epub 2018 Feb 2 doi: 10.1038/nrendo.2017.180. PMID: 29393299
Central sensitization in chronic low back pain: A narrative review.
Sanzarello I, Merlini L, Rosa MA, Perrone M, Frugiuele J, Borghi R, Faldini C
J Back Musculoskelet Rehabil 2016 Nov 21;29(4):625-633. doi: 10.3233/BMR-160685. PMID: 27062464
Estrogen Deficiency and the Origin of Obesity during Menopause.
Lizcano F, Guzmán G
Biomed Res Int 2014;2014:757461. Epub 2014 Mar 6 doi: 10.1155/2014/757461. PMID: 24734243Free PMC Article

Diagnosis

Chronic Pain in the Elderly: Mechanisms and Distinctive Features.
Tinnirello A, Mazzoleni S, Santi C
Biomolecules 2021 Aug 23;11(8) doi: 10.3390/biom11081256. PMID: 34439922Free PMC Article
Diagnosis and Treatment of Multiple Sclerosis: A Review.
McGinley MP, Goldschmidt CH, Rae-Grant AD
JAMA 2021 Feb 23;325(8):765-779. doi: 10.1001/jama.2020.26858. PMID: 33620411
Central Sensitization in Musculoskeletal Pain: Lost in Translation?
van Griensven H, Schmid A, Trendafilova T, Low M
J Orthop Sports Phys Ther 2020 Nov;50(11):592-596. doi: 10.2519/jospt.2020.0610. PMID: 33131390
Neuropathic Pain: Central vs. Peripheral Mechanisms.
Meacham K, Shepherd A, Mohapatra DP, Haroutounian S
Curr Pain Headache Rep 2017 Jun;21(6):28. doi: 10.1007/s11916-017-0629-5. PMID: 28432601
Sigma-1 Receptor and Pain.
Merlos M, Romero L, Zamanillo D, Plata-Salamán C, Vela JM
Handb Exp Pharmacol 2017;244:131-161. doi: 10.1007/164_2017_9. PMID: 28275913

Therapy

Diagnosis and Treatment of Multiple Sclerosis: A Review.
McGinley MP, Goldschmidt CH, Rae-Grant AD
JAMA 2021 Feb 23;325(8):765-779. doi: 10.1001/jama.2020.26858. PMID: 33620411
Treatment of central sensitization in patients with chronic pain: time for change?
Nijs J, Leysen L, Vanlauwe J, Logghe T, Ickmans K, Polli A, Malfliet A, Coppieters I, Huysmans E
Expert Opin Pharmacother 2019 Nov;20(16):1961-1970. Epub 2019 Jul 29 doi: 10.1080/14656566.2019.1647166. PMID: 31355689
Advances in Understanding, Diagnosis, and Treatment of Tinnitus.
Tang D, Li H, Chen L
Adv Exp Med Biol 2019;1130:109-128. doi: 10.1007/978-981-13-6123-4_7. PMID: 30915704
Neuroinflammation and Central Sensitization in Chronic and Widespread Pain.
Ji RR, Nackley A, Huh Y, Terrando N, Maixner W
Anesthesiology 2018 Aug;129(2):343-366. doi: 10.1097/ALN.0000000000002130. PMID: 29462012Free PMC Article
Inflammation in the pathophysiology of neuropathic pain.
Sommer C, Leinders M, Üçeyler N
Pain 2018 Mar;159(3):595-602. doi: 10.1097/j.pain.0000000000001122. PMID: 29447138

Prognosis

Diagnosis and Treatment of Multiple Sclerosis: A Review.
McGinley MP, Goldschmidt CH, Rae-Grant AD
JAMA 2021 Feb 23;325(8):765-779. doi: 10.1001/jama.2020.26858. PMID: 33620411
Transition from Acute to Chronic Pain: Evaluating Risk for Chronic Postsurgical Pain.
Fregoso G, Wang A, Tseng K, Wang J
Pain Physician 2019 Sep;22(5):479-488. PMID: 31561647
Febrile seizures.
Patterson JL, Carapetian SA, Hageman JR, Kelley KR
Pediatr Ann 2013 Dec;42(12):249-54. doi: 10.3928/00904481-20131122-09. PMID: 24295158
Preventive analgesia.
Dahl JB, Kehlet H
Curr Opin Anaesthesiol 2011 Jun;24(3):331-8. doi: 10.1097/ACO.0b013e328345afd9. PMID: 21478742
Secondary dystonias.
Hartmann A, Pogarell O, Oertel WH
J Neurol 1998 Aug;245(8):511-8. doi: 10.1007/s004150050235. PMID: 9747914

Clinical prediction guides

Diagnosis and Treatment of Multiple Sclerosis: A Review.
McGinley MP, Goldschmidt CH, Rae-Grant AD
JAMA 2021 Feb 23;325(8):765-779. doi: 10.1001/jama.2020.26858. PMID: 33620411
Symptoms of menopause - global prevalence, physiology and implications.
Monteleone P, Mascagni G, Giannini A, Genazzani AR, Simoncini T
Nat Rev Endocrinol 2018 Apr;14(4):199-215. Epub 2018 Feb 2 doi: 10.1038/nrendo.2017.180. PMID: 29393299
Validation of a new coma scale: The FOUR score.
Wijdicks EF, Bamlet WR, Maramattom BV, Manno EM, McClelland RL
Ann Neurol 2005 Oct;58(4):585-93. doi: 10.1002/ana.20611. PMID: 16178024
A new rating scale for age-related white matter changes applicable to MRI and CT.
Wahlund LO, Barkhof F, Fazekas F, Bronge L, Augustin M, Sjögren M, Wallin A, Ader H, Leys D, Pantoni L, Pasquier F, Erkinjuntti T, Scheltens P; European Task Force on Age-Related White Matter Changes
Stroke 2001 Jun;32(6):1318-22. doi: 10.1161/01.str.32.6.1318. PMID: 11387493
Understanding postoperative fatigue.
Rose EA, King TC
Surg Gynecol Obstet 1978 Jul;147(1):97-102. PMID: 351838

Recent systematic reviews

Effectiveness of Pain Neuroscience Education in Patients with Chronic Musculoskeletal Pain and Central Sensitization: A Systematic Review.
Lepri B, Romani D, Storari L, Barbari V
Int J Environ Res Public Health 2023 Feb 24;20(5) doi: 10.3390/ijerph20054098. PMID: 36901108Free PMC Article
Deep brain stimulation targets in epilepsy: Systematic review and meta-analysis of anterior and centromedian thalamic nuclei and hippocampus.
Vetkas A, Fomenko A, Germann J, Sarica C, Iorio-Morin C, Samuel N, Yamamoto K, Milano V, Cheyuo C, Zemmar A, Elias G, Boutet A, Loh A, Santyr B, Gwun D, Tasserie J, Kalia SK, Lozano AM
Epilepsia 2022 Mar;63(3):513-524. Epub 2022 Jan 3 doi: 10.1111/epi.17157. PMID: 34981509
Sleep, cerebrospinal fluid, and the glymphatic system: A systematic review.
Chong PLH, Garic D, Shen MD, Lundgaard I, Schwichtenberg AJ
Sleep Med Rev 2022 Feb;61:101572. Epub 2021 Nov 18 doi: 10.1016/j.smrv.2021.101572. PMID: 34902819Free PMC Article
Long term methylphenidate exposure and growth in children and adolescents with ADHD. A systematic review and meta-analysis.
Carucci S, Balia C, Gagliano A, Lampis A, Buitelaar JK, Danckaerts M, Dittmann RW, Garas P, Hollis C, Inglis S, Konrad K, Kovshoff H, Liddle EB, McCarthy S, Nagy P, Panei P, Romaniello R, Usala T, Wong ICK, Banaschewski T, Sonuga-Barke E, Coghill D, Zuddas A; ADDUCE Consortium
Neurosci Biobehav Rev 2021 Jan;120:509-525. Epub 2020 Oct 17 doi: 10.1016/j.neubiorev.2020.09.031. PMID: 33080250
Estrogen Deficiency and the Origin of Obesity during Menopause.
Lizcano F, Guzmán G
Biomed Res Int 2014;2014:757461. Epub 2014 Mar 6 doi: 10.1155/2014/757461. PMID: 24734243Free PMC Article

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