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Adenomyoma

MedGen UID:
64617
•Concept ID:
C0206622
•
Neoplastic Process
Synonym: Adenomyomas
SNOMED CT: Adenomyoma (40293003)
 
Monarch Initiative: MONDO:0005635

Definition

A benign neoplasm characterized by the presence of a glandular and a mesenchymal (fibromyomatous) component. It occurs in the uterine corpus, cervix, and uterine ligaments. A variant of adenomyoma associated with glandular architectural complexity is called atypical polypoid adenomyoma. Simple polypectomy is usually curative. Atypical polypoid adenomyoma may recur following polypectomy. [from NCI]

Professional guidelines

PubMed

Minimally invasive treatment of adenomyosis.
Dueholm M
Best Pract Res Clin Obstet Gynaecol 2018 Aug;51:119-137. Epub 2018 Feb 15 doi: 10.1016/j.bpobgyn.2018.01.016. PMID: 29555380
Medical treatment for adenomyosis and/or adenomyoma.
Tsui KH, Lee WL, Chen CY, Sheu BC, Yen MS, Chang TC, Wang PH
Taiwan J Obstet Gynecol 2014 Dec;53(4):459-65. doi: 10.1016/j.tjog.2014.04.024. PMID: 25510683
Adenomyosis: new knowledge is generating new treatment strategies.
Benagiano G, Brosens I, Carrara S
Womens Health (Lond) 2009 May;5(3):297-311. doi: 10.2217/whe.09.7. PMID: 19392615

Recent clinical studies

Etiology

Cystic adenomyoma surgery.
Kerbage Y, Dericquebourg S, Collinet P, Verpillat P, Giraudet G, Rubod C
J Gynecol Obstet Hum Reprod 2022 Mar;51(3):102313. Epub 2022 Jan 11 doi: 10.1016/j.jogoh.2022.102313. PMID: 35031510
Uterine adenomyosis and adenomyoma: the surgical approach.
Osada H
Fertil Steril 2018 Mar;109(3):406-417. doi: 10.1016/j.fertnstert.2018.01.032. PMID: 29566853
Treatment options and reproductive outcome for adenomyosis-associated infertility.
Soave I, Wenger JM, Pluchino N, Marci R
Curr Med Res Opin 2018 May;34(5):839-849. Epub 2017 Nov 10 doi: 10.1080/03007995.2017.1393404. PMID: 29046066
Gallbladder adenomyomatosis: Diagnosis and management.
Golse N, Lewin M, Rode A, Sebagh M, Mabrut JY
J Visc Surg 2017 Oct;154(5):345-353. Epub 2017 Aug 24 doi: 10.1016/j.jviscsurg.2017.06.004. PMID: 28844704
Uterus-sparing operative treatment for adenomyosis.
Grimbizis GF, Mikos T, Tarlatzis B
Fertil Steril 2014 Feb;101(2):472-87. Epub 2013 Nov 26 doi: 10.1016/j.fertnstert.2013.10.025. PMID: 24289992

Diagnosis

Cystic adenomyoma surgery.
Kerbage Y, Dericquebourg S, Collinet P, Verpillat P, Giraudet G, Rubod C
J Gynecol Obstet Hum Reprod 2022 Mar;51(3):102313. Epub 2022 Jan 11 doi: 10.1016/j.jogoh.2022.102313. PMID: 35031510
The Effect of Uterine Adenomyosis on IVF Outcomes: a Systematic Review and Meta-analysis.
Cozzolino M, Tartaglia S, Pellegrini L, Troiano G, Rizzo G, Petraglia F
Reprod Sci 2022 Nov;29(11):3177-3193. Epub 2022 Jan 3 doi: 10.1007/s43032-021-00818-6. PMID: 34981458
Atypical polypoid adenomyoma.
Grindstaff S, Banet N
Int J Gynecol Cancer 2021 Apr;31(4):639-640. doi: 10.1136/ijgc-2020-001886. PMID: 33795408
Gallbladder adenomyomatosis: Diagnosis and management.
Golse N, Lewin M, Rode A, Sebagh M, Mabrut JY
J Visc Surg 2017 Oct;154(5):345-353. Epub 2017 Aug 24 doi: 10.1016/j.jviscsurg.2017.06.004. PMID: 28844704
My approach to the interpretation of endometrial biopsies and curettings.
McCluggage WG
J Clin Pathol 2006 Aug;59(8):801-12. doi: 10.1136/jcp.2005.029702. PMID: 16873562Free PMC Article

Therapy

The "freeze-all" strategy seems to improve the chances of birth in adenomyosis-affected women.
Bourdon M, Santulli P, Maignien C, Bordonne C, Millischer AE, Chargui A, Marcellin L, Mantelet LM, Fouque Gadol L, Chapron C
Fertil Steril 2024 Mar;121(3):460-469. Epub 2023 Dec 4 doi: 10.1016/j.fertnstert.2023.11.039. PMID: 38056519
Ultrasound-guided percutaneous microwave ablation of adenomyosis: a narrative review.
Zhang S, Wang K, Di A, Yu D, Yao T
Ann Palliat Med 2021 Nov;10(11):12003-12011. doi: 10.21037/apm-21-3133. PMID: 34872323
Atypical polypoid adenomyoma follow-up and management: Systematic review of case reports and series and meta-analysis.
Biasioli A, Londero AP, Orsaria M, Scrimin F, Mangino FP, Bertozzi S, Mariuzzi L, Cagnacci A
Medicine (Baltimore) 2020 Jun 26;99(26):e20491. doi: 10.1097/MD.0000000000020491. PMID: 32590732Free PMC Article
Uterine adenomyosis and adenomyoma: the surgical approach.
Osada H
Fertil Steril 2018 Mar;109(3):406-417. doi: 10.1016/j.fertnstert.2018.01.032. PMID: 29566853
Spectrum of MR features in adenomyosis.
Tamai K, Koyama T, Umeoka S, Saga T, Fujii S, Togashi K
Best Pract Res Clin Obstet Gynaecol 2006 Aug;20(4):583-602. Epub 2006 Mar 24 doi: 10.1016/j.bpobgyn.2006.01.009. PMID: 16564228

Prognosis

Gallbladder adenomyomatosis: Diagnosis and management.
Golse N, Lewin M, Rode A, Sebagh M, Mabrut JY
J Visc Surg 2017 Oct;154(5):345-353. Epub 2017 Aug 24 doi: 10.1016/j.jviscsurg.2017.06.004. PMID: 28844704
A multiple perspectives on atypical polypoid adenomyoma of uterus.
Jiang QY, Wang L, Wu RJ
Gynecol Endocrinol 2013 Jul;29(7):623-5. Epub 2013 Mar 25 doi: 10.3109/09513590.2013.777418. PMID: 23527553
Pathology of mixed Müllerian tumours.
D'Angelo E, Prat J
Best Pract Res Clin Obstet Gynaecol 2011 Dec;25(6):705-18. Epub 2011 Jul 13 doi: 10.1016/j.bpobgyn.2011.05.010. PMID: 21742560
Cystic uterine tumors.
Protopapas A, Milingos S, Markaki S, Loutradis D, Haidopoulos D, Sotiropoulou M, Antsaklis A
Gynecol Obstet Invest 2008;65(4):275-80. Epub 2008 Jan 24 doi: 10.1159/000113871. PMID: 18216491
Spectrum of MR features in adenomyosis.
Tamai K, Koyama T, Umeoka S, Saga T, Fujii S, Togashi K
Best Pract Res Clin Obstet Gynaecol 2006 Aug;20(4):583-602. Epub 2006 Mar 24 doi: 10.1016/j.bpobgyn.2006.01.009. PMID: 16564228

Clinical prediction guides

The "freeze-all" strategy seems to improve the chances of birth in adenomyosis-affected women.
Bourdon M, Santulli P, Maignien C, Bordonne C, Millischer AE, Chargui A, Marcellin L, Mantelet LM, Fouque Gadol L, Chapron C
Fertil Steril 2024 Mar;121(3):460-469. Epub 2023 Dec 4 doi: 10.1016/j.fertnstert.2023.11.039. PMID: 38056519
Atypical polypoid adenomyoma follow-up and management: Systematic review of case reports and series and meta-analysis.
Biasioli A, Londero AP, Orsaria M, Scrimin F, Mangino FP, Bertozzi S, Mariuzzi L, Cagnacci A
Medicine (Baltimore) 2020 Jun 26;99(26):e20491. doi: 10.1097/MD.0000000000020491. PMID: 32590732Free PMC Article
Clinicopathologic Characteristics of Gallbladder Adenomyomas and the Contribution of Macroscopic Sampling in Adenomyoma Diagnosis.
Erhan SŞ, Keser SH, Özer M
Turk Patoloji Derg 2020;36(1):11-16. doi: 10.5146/tjpath.2019.01471. PMID: 31633192Free PMC Article
Structural and molecular features of the endomyometrium in endometriosis and adenomyosis.
Benagiano G, Brosens I, Habiba M
Hum Reprod Update 2014 May-Jun;20(3):386-402. Epub 2013 Oct 18 doi: 10.1093/humupd/dmt052. PMID: 24140719
History of adenomyosis.
Benagiano G, Brosens I
Best Pract Res Clin Obstet Gynaecol 2006 Aug;20(4):449-63. Epub 2006 Mar 2 doi: 10.1016/j.bpobgyn.2006.01.007. PMID: 16515887

Recent systematic reviews

The Effect of Uterine Adenomyosis on IVF Outcomes: a Systematic Review and Meta-analysis.
Cozzolino M, Tartaglia S, Pellegrini L, Troiano G, Rizzo G, Petraglia F
Reprod Sci 2022 Nov;29(11):3177-3193. Epub 2022 Jan 3 doi: 10.1007/s43032-021-00818-6. PMID: 34981458
Atypical polypoid adenomyoma follow-up and management: Systematic review of case reports and series and meta-analysis.
Biasioli A, Londero AP, Orsaria M, Scrimin F, Mangino FP, Bertozzi S, Mariuzzi L, Cagnacci A
Medicine (Baltimore) 2020 Jun 26;99(26):e20491. doi: 10.1097/MD.0000000000020491. PMID: 32590732Free PMC Article
Immunophenotype of Atypical Polypoid Adenomyoma of the Uterus: Diagnostic Value and Insight on Pathogenesis.
Travaglino A, Raffone A, Saccone G, Fuggi M, De Placido G, Mascolo M, Mollo A, Insabato L, Zullo F
Appl Immunohistochem Mol Morphol 2020 Sep;28(8):646-653. doi: 10.1097/PAI.0000000000000780. PMID: 31855579
Uterus-sparing operative treatment for adenomyosis.
Grimbizis GF, Mikos T, Tarlatzis B
Fertil Steril 2014 Feb;101(2):472-87. Epub 2013 Nov 26 doi: 10.1016/j.fertnstert.2013.10.025. PMID: 24289992
Stepwise approach and surgery for gallbladder adenomyomatosis: a mini-review.
Pellino G, Sciaudone G, Candilio G, Perna G, Santoriello A, Canonico S, Selvaggi F
Hepatobiliary Pancreat Dis Int 2013 Apr;12(2):136-42. doi: 10.1016/s1499-3872(13)60022-3. PMID: 23558066

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